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Date:9/17/2007

terially from these statements. These risks and uncertainties include, among others: the content and timing of decisions by the Japanese MHLW, the U.S. Food and Drug Administration, the European Medicines Agency and other regulatory authorities concerning BH4 products; results and timing of current and planned clinical trials of 6R-BH4 for other indications; Asubio Pharma's success in marketing BH4 for PKU in Japan, if approved and those factors detailed in BioMarin's filings with the Securities and Exchange Commission, including, without limitation, the factors contained under the caption "Risk Factors" in BioMarin's 2006 Annual Report on Form 10-K, as amended, and the factors contained in BioMarin's reports on Form 8-K. Stockholders are urged not to place undue reliance on forward-looking statements, which speak only as of the date hereof. BioMarin is under no obligation, and expressly disclaims any obligation to update or alter any forward-looking statement, whether as a result of new information, future events or otherwise.

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Eugenia Shen Susan Berg

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