Navigation Links
Evotec Reports Details of the Positive Proof-of-Concept Phase II Study in Insomnia With EVT 201
Date:9/5/2007

tion in TWT produced by EVT 201 was statistically significant for all hours of the night apart from hour 7 which came very close to reaching statistical significance (p= 0.058).

Commenting on the results, Dr John Kemp, Chief Research & Development Officer, Evotec AG, said: "I'm absolutely delighted with the results of this proof-of-concept Phase II study. The magnitude of effect on sleep maintenance appears more robust than those seen with other agents in similar cross-over design studies. In particular, we are not aware of similar studies that have demonstrated such statistically significant effects on Total Wake Time in the second half of the night and Total Wake Time each hour."

Jorn Aldag, President and Chief Executive Officer, Evotec AG, said: "Although certain aspects of insomnia are addressed by current treatments, there is no drug yet available which meets all the needs of insomnia patients. In our study EVT 201 demonstrated extremely robust findings on all key aspects of the problems faced by insomniacs, i.e. sleep onset and sleep maintenance and yet was without the patients feeling any drug hang-over effects after waking in the morning. We believe this gives EVT 201 a very competitive profile compared to the currently available insomnia treatments and to those in late stage clinical development."

Principal Investigator Dr James Walsh, Executive Director of the Sleep Medicine and Research Center, St John's Mercy Medical Center, Chesterfield, Missouri, US, said: "Due to its partial positive allosteric modulation of GABAA receptors, EVT 201 provides a novel approach to the treatment of insomnia, yet since the GABAA system is a well understood pathway, the risk of unexpected side effect findings are low compared to completely novel mechanisms. This together with robust effect sizes seen in this study, particularly with regard to sleep maintenance, offers considerable promise for the drug as a treatment for insomnia patients."

A second P
'/>"/>

SOURCE Evotec AG
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related biology technology :

1. TomoTherapy reports 86% revenue jump, $131M net loss in Q1
2. Sonic Foundry reports GAAP loss as Q2 revenues rise
3. Fiserv reports $113.5 million in Q1 profit
4. Third Wave reports net loss of $18.9M for 2006
5. Musicnotes reports 45 percent growth in 2006
6. Sonic Foundry reports net loss, higher revenue
7. Sonic Foundry reports first cash-positive quarter
8. Merge Healthcare reports $10.8M net loss in Q3
9. Third Wave reports $5.2M third quarter loss
10. Merge Healthcare appoints new CEO, reports $215 million Q2 loss
11. Merge files financial reports by market opening
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2009)... accurate test to find undetected landmines. , Students from ... that glows green when it comes into contact with ... be mixed into a colourless solution that, when sprayed ... the presence of landmines. , Researchers say that ... delivered from the air onto areas thought to contain ...
(Date:12/16/2009)... certain cardiac pacemakers may inadequately stimulate a patient,s ... scan due to the magnetic pulses mixing with ... inadequate stimulation is potentially dangerous for the patient ... in BioMed Central,s open access journal BioMedical ... technique that uses a magnetic field instead of ...
(Date:12/16/2009)... the Nanyang Technological University (NTU) signed the Memorandum ... for Scientific Research (CNRS) and the Thales Group ... laboratory, the three parties are meeting again in ... Laboratory at NTU. , Located at the ... harness the latest in science and technology to ...
(Date:12/16/2009)... Dec. 16 WaferGen Biosystems, Inc. (OTC ... genetic analysis systems, today announced that it will ... innovative service for gene-expression profiling using its SmartChip(TM) ... provides the most comprehensive human microRNA panel of ... company,s SmartChip service offers customers the use of ...
Breaking Biology Technology:FDA researchers identify new MRI safety risk for patients with pacemakers 2New Singapore-French nanotech lab opens at NTU 2New Singapore-French nanotech lab opens at NTU 3WaferGen to Launch Human MicroRNA Panel for Gene-Expression Profiling of 885 MicroRNA for Its Service Using the SmartChip(TM) Real-Time PCR System 2WaferGen to Launch Human MicroRNA Panel for Gene-Expression Profiling of 885 MicroRNA for Its Service Using the SmartChip(TM) Real-Time PCR System 3WaferGen to Launch Human MicroRNA Panel for Gene-Expression Profiling of 885 MicroRNA for Its Service Using the SmartChip(TM) Real-Time PCR System 4
... LaCrosse, Wis.- Gundersen Lutheran Health System is reducing surgery ... the management of its surgical instruments and trays by ... Paul, Minn.- based Lawson Software. , ,Gundersen Lutheran ... one of the nation's largest group medical practices, community ...
... Inc., an ATM and point-of-sale (POS) processing business, ... volume increase more than 57% in 2003 to 223 ... 57% was tremendous and makes ACCEL/Exchange one of the ... Vice President of Products and Networks for Fiserv EFT/CNS. ...
... of the 1960s have largely disappeared, the music culture generated ... Farewell Tours in basketball stadiums). , ,The biotech culture ... in a series of concert hall venues by the investment ... companies of our day. The Woodstock of these meetings is ...
Other Biology Technology:Gunderson Lutheran Implements Instrument Management Systems 2The Biotech Concert Halls of the Decade of 2000 2
(Date:12/16/2009)... form an intricate network of interactions. Today,s techniques, ... molecular reactions outside the cells. Since molecular concentrations ... laboratory, scientists suspect that the kinetics of molecular ... probes. We expected the cellular reaction speed to ... "However, our novel optical approach showed that ...
(Date:12/16/2009)... CA Tom Bowman, an expert in communicating scientific ... Change, has developed a series of graphics that translate ... Change (IPCC) report for public audiences. These new graphics ... need to make informed decisions about climate change risks ... a means to clearly and accurately communicate findings in ...
(Date:12/16/2009)... DigitalPersona, Inc., a leader in ... an agreement with IBM to deploy a ... technology on IBM SurePOS 500 retail systems. ... applications to more easily and quickly identify ... linked to the individuals who perform them. ...
Breaking Biology News(10 mins):Looking for the heartbeat of cellular networks 2Bowman creates graphic translation of climate change data 2DigitalPersona Fingerprint Sensor Technology Ships on IBM SurePOS 500 Retail Systems 2PA Helping Life Science Companies Secure Venture Capital Needed to Expand Gov Rendell Says 13911 1PA Helping Life Science Companies Secure Venture Capital Needed to Expand Gov Rendell Says 13911 2Injury Research and Health Organizations Urge Congress to Save Lives and Money by Including Injury Prevention in Health Care Reform 56472 1Injury Research and Health Organizations Urge Congress to Save Lives and Money by Including Injury Prevention in Health Care Reform 56472 2Injury Research and Health Organizations Urge Congress to Save Lives and Money by Including Injury Prevention in Health Care Reform 56472 3Its Now or Never Deadline for Olympic Hopeful Skater With Secret Weapon 56470 1Its Now or Never Deadline for Olympic Hopeful Skater With Secret Weapon 56470 2
... nearly a decade, scientists have been trying to fully ... contributes to many malignant brain and prostate cancers. While ... components have remained a mystery. Researchers at Whitehead Institute ... that may present drug makers with a significant new ...
... one thousandth the diameter of a human hair, a ... another during,cell division. Her uncanny surgical skills have added ... one cell divides into two -- a,process fundamental to ... Biology, Leocadia Paliulis and,Bruce Nicklas report their progress in ...
... first time, a group of scientists has accomplished the ... the ecosystems on Earth, and the outlook is troubling. ... Millennium Ecosystem Assessment program will issue its primary report ... D.C., Tokyo, Beijing, New Delhi, Brasilia, Cairo, Nairobi and ...
Other Biology News:Researchers identify target for cancer drugs 2Needling Chromosomes Reveals Cell Division Secret 2Needling Chromosomes Reveals Cell Division Secret 3Scientists collaborate to assess health of global environment 2Scientists collaborate to assess health of global environment 3
100 adhesive strips....
Homo sapiens palladin...
Mouse P-Selectin/CD62P MAb (Clone 127933)...
Molecular Biological Resources has extensive abilities cloning and expression of prokaryotic and eukaryotic proteins. Please contact lloconne@molbiores.com to discuss your project. Contact lloconne@...
Biology Products: