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Epizyme, Inc. Provides Third Quarter 2013 Financial Results and Corporate Update
Date:10/22/2013

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  • Broadening Program into INI1-Deficient Tumors in 2014: Epizyme plans to initiate clinical trials in patients with tumors in which there is genetically altered INI1 after completion of the ongoing Phase 1 study. EZH2 plays a driving oncogenic role in INI1-deficient tumors, as exemplified in a paper published in the April 2013 Proceedings of the National Academy of Sciences in which Epizyme scientists demonstrated sustained tumor regressions in pre-clinical studies of malignant rhabdoid tumors (MRT) and in an October 21, 2013 presentation at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics that describes the oncogenic role of EZH2 in synovial sarcomas, a malignancy in which INI1 function is altered as a result of a specific chromosomal translocation (SS18-SSX). In the major markets, synovial sarcoma has an annual incidence of 1,700 patients, and other INI1-deficient tumors together have an annual incidence of 700 patients.
  • Additional Business Highlights

  • Continued Pipeline Development of Personalized Therapeutics: Pre-clinical studies are ongoing to identify additional genetically defined cancers for potential treatment with Epizyme's therapeutic candidates. Planned clinical studies in MLL-PTD and INI1-deficient tumors, focusing on synovial sarcoma, are examples of the novel therapeutic insights provided by Epizyme's product platform. Epizyme also continues to advance the HMT targets in the GSK collaboration as well as other non-partnered HMT targets.
  • Strengthened Intellectual Property Portfolio: In August 2013, the U.S. Patent and Trademark Office (USPTO) issued a Notice of Allowance for U.S. Patent Application No. 13/310,157 "SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS" with claims covering the novel compound EPZ-567
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