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Epistem plc and AstraZeneca Complete Plucked Hair Biomarker Study for Oncology Drug Development
Date:2/5/2008

MANCHESTER, England, February 5 /PRNewswire-FirstCall/ -- Epistem plc (LSE:EHP) announced today that it had successfully completed a preliminary study with AstraZeneca for the use of its proprietary, minimally invasive plucked human hair biomarker technology to help steer oncology drug development. The technology includes analysing gene expression change in RNA extracted from the bulb of cells located at the base of a single human plucked hair. Changes in gene expression can be used to identify biomarkers ('core gene sets') to aid decision-making in the drug development process.

The companies have demonstrated that single plucked hairs sampled over multiple time points provide effective levels of RNA for gene expression measurement. The study also showed that the process was well tolerated by subjects and samples proved robust during shipment and storage. Over 85% of hairs sampled were evaluable for measurement. Further analysis of single hairs also established reliable detection of over 13,000 genes in single hairs, which can be used to establish 'core gene sets' for biomarker drug discovery, validation and patient selection. A joint scientific abstract of the study was recently presented at the AACR-NCI-EORTC meeting in San Francisco.

The hair biomarker provides the industry with a potentially powerful tool to measure the effects of new cancer treatments and their translation from preclinical through to clinical phases, enabling more informed go/no go decisions to be undertaken at an earlier stage. The identification of appropriate biomarkers within drug development is gaining greater importance with the launch last year of The Biomarkers Consortium founded by The Foundation for the National Institutes of Health (FNIH), the National Institutes of Health (NIH), the Food and Drug Administration (FDA), and the Pharmaceutical Research and Manufacturers of America (PhRMA). AstraZeneca is an active member of the consortium, with the consortium's aim
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