Navigation Links
Epidemic outbreaks caused by environment, not evolution
Date:8/4/2014

Researchers have traced genetic changes in a bacterial pathogen over 450 years, and claim that epidemics of bacterial disease in human history may be caused by chance environmental changes rather than genetic mutations.

In a study published in PNAS, a team led by the University of Warwick analysed 149 genomes of Salmonella enterica serovar Paratyphi A, which is a major cause of enteric fever. Enteric fever is currently estimated at 27 million clinical cases each year, resulting in 200,000 deaths.

Lead author, Zhemin Zhou from Warwick Medical School, said: "When epidemics break out, many scientists suspect they have been driven by increased virulence or fitness, possibly associated with the gain of novel genes or mutations. We wanted to trace genetic changes in a prominent bacterial pathogen back to see if this was true."

The team reconstructed the genealogy, global transmission history and evolutionary history and found the pathogen originated at least 450 years ago, and had not changed dramatically over the centuries. This suggests that the pathogen had not become more efficient at causing enteric fever.

Zhemin Zhou said: "We found the pathogen formed seven distinct lineages that spread globally since the mid-19th century. Tracing the pathogen, we found there were genetic mutations that may have transiently improved drug resistance or improved the metabolic efficiency. However, most mutations were short-lived and removed by evolutionary forces."

Senior author Professor Mark Achtman, Warwick Medical School, said: "We interpret the history of Paratyphi A as reflecting drift rather than progressive evolution. Our results indicate the crucial genomic contents of Paratyphi A, that cause enteric fever in humans, accumulated very early in its history.

"This implies that many epidemics and pandemics of bacterial disease in human history reflected chance environmental events, including geographical spread and/or transmission to nave hosts, rather than the recent evolution of particularly virulent organisms."


'/>"/>

Contact: Kelly Parkes-Harrison
k.e.parkes@warwick.ac.uk
0247-615-0868
University of Warwick
Source:Eurekalert

Related biology technology :

1. AASM Partners with CDC to Address Chronic Sleep Loss Epidemic
2. Waterloo Heights, a Neighborhood Smiles Dental Practice is Taking a Bold New Approach to the Cavity Epidemic
3. Dr. Kevin T. Tanty Takes a Bold New Approach to the Cavity Epidemic
4. Neighborhood Smiles of La Crosse Takes a Bold New Approach to the Tooth Decay Epidemic
5. Neighborhood Smiles of Green Bay Offers a New Approach to the Cavity Epidemic
6. Omaha Residents May See A Frightening Bed Bug Epidemic, MyCleaningProducts.com Offers Non Pesticide Treatment To Aid Victims
7. Relief Organizations Worry Sandy Clothing Donations Would Start Bed Bug Epidemic; Bed Bug Removal Guide Advises Disaster Victims to Prepare for It with Bed Bug Bully
8. Ebola Virus Gene Replikin Count Increased Sixteen-fold in 2013 in Advance of Current Outbreaks
9. New Norovirus "Vomiting Virus" Strain Spreads Like Wildfire, My Cleaning Products Publishes Green Guide to Prevent Norovirus Outbreaks in One's Home
10. Tropical Storm Debby Pounds Florida With Heavy Rain. Green Bean Buddy Gives Reason Why Home Owners Should Prepare For Mold Outbreaks
11. US Lab Deployed to Boost Mexicos Response to Outbreaks of Infectious Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)...  Soligenix, Inc. (OTCQB: SNGX) (Soligenix or the ... and commercializing products to treat rare diseases where ... the long-term follow-up data from its Phase 2 ... Defense Regulator (IDR), in the treatment of oral ... undergoing chemoradiation therapy (CRT).  The additional 12-month safety ...
(Date:12/8/2016)...  Partnering to fuel Philadelphia,s ... Southeastern Pennsylvania (" Ben Franklin ... Independence Blue Cross; and Safeguard Scientifics ("Safeguard") (NYSE: ... $6 million funding initiative over a four year period ... to a burgeoning economic vitality in digital health, ...
(Date:12/7/2016)... , Dec. 7, 2016 Neogen Corporation ... named Dr. Dan Kephart as its chief ... Kephart will assume his responsibilities at Neogen effective Jan. ... development director for the agribusiness unit of Thermo Fisher ... development at Life Technologies. His extensive industry experience also ...
(Date:12/7/2016)... PUNE, India , December 8, 2016 The report "Acrylic ... (Building & Construction, Packaging, Automotive, Consumer Goods) - Global Forecast to 2026", published ... is projected to reach USD 1,173.6 Million by 2026, registering an of CAGR ... ... MarketsandMarkets Logo ...
Breaking Biology Technology:
(Date:11/30/2016)... WARSAW, Poland , Nov. 30, 2016 Not many of us ... most crucial aspects of recovery so we need to do it well. Inadequate sleep ... heart problems, high blood pressure, stroke, diabetes, and even cancer. Maybe now ... a Christmas present that could help them to manage their sleep quality? ... ...
(Date:11/28/2016)... "The biometric system market ... The biometric system market is in the growth stage ... future. The biometric system market is expected to be ... CAGR of 16.79% between 2016 and 2022. Government initiative ... in smartphones, rising use of biometric technology in financial ...
(Date:11/19/2016)... Nov. 18, 2016 Securus Technologies, a leading ... public safety, investigation, corrections and monitoring, announced today that ... ICSolutions, to have an independent technology judge determine who ... modern high tech/sophisticated telephone calling platform, and the best ... they do most of what we do – which ...
Breaking Biology News(10 mins):