Navigation Links
EpiVax Research on Tregitopes Wins 2010 AAPS Innovation in Biotechnology Award
Date:5/25/2010

EpiVax Research on Tregitopes Wins 2010 AAPS Innovation in Biotechnology Award. Providence-based biotechnology company selected from more than 100 global research initiatives aimed at impacting drug development.

Providence, RI; San Francisco, CA (Vocus) May 25, 2010 -- At the American Association of Pharmaceutical Scientists’ (AAPS) 2010 National Biotechnology Conference (NBC) in San Francisco, AAPS President Danny D. Shen, Ph.D., presented an award for “Innovation in Biotechnology” to Providence-based EpiVax; commemorating their contributions to the pharmaceutical sciences. EpiVax’s Tregitope research was selected from more than 100 submissions globally. The award recognizes innovation demonstrating how basic science can impact drug development and represents a creative new idea expected to have a significant impact in the biotechnology field.

“The award winners announced are a testament to the advances AAPS members and their colleagues have made in the field of biotechnology,” said AAPS Associate Executive Director Peter Inchauteguiz. “Recognizing these scientists for their hard work and achievements in biotherapeutics is a great way for us to kick-off this national conference in San Francisco.”

EpiVax’s award-winning research entitled, “Preclinical Design of Less Immunogenic Biologics: Tregitopes and Tolerance,” was done with the support of researchers from the following institutions: Brigham and Women’s Hospital; Children’s Hospital Boston; Children’s Hospital of Philadelphia: Institute for Immunology and Informatics, University of Rhode Island: and University of Maryland.

When asked about the significance of the Tregitope discovery, Harald Kropshofer, Ph.D, Global Coordinator Immunosafety, F. Hoffmann-La Roche AG has said “I believe that Tregitope technology represents a shift in thinking that may allow the biotherapeutics industry to address a range of unanswered questions related to side-effects based on immunogenicity; it truly has the potential to provide important advances in minimizing unwanted immune responses through tolerance induction.”

The discovery of natural regulatory T cell epitopes (Tregitopes) in the sequence of therapeutics mAbs represents a paradigm shift for protein therapeutics, allergy, autoimmunity and transplantation. Tregitopes are currently being evaluated in vitro and in vivo in five collaborating academic laboratories. For example, investigations in Transplantation (MLR, cardiac transplant model) are being carried out by Mo Sayegh and Nader Najafian (Transplantation Research Center, Brigham and Woman's Hospital and Children's Hospital Boston, Harvard Medical School), in protein therapeutics (FVIII) and autoimmunity (Type 1 Diabetes) by David Scott (Department of Surgery, Microbiology, University of Maryland School of Medicine), in Multiple Sclerosis by Samia Khoury (Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School), have demonstrated the Tregitopes activate natural Tregs and induce adoptive tolerance to a range of target antigens. Current studies are focusing on dose, delivery and route of administration to maximize the Tregitope effect. Safety is expected to be excellent, as Tregitopes are believed to be the active component of a widely used immunotherapy, IVIG.

About Tregitope
Tregitopes are a set of peptides that specifically activate CD4+CD25+FoxP3+ natural regulatory T cells (nTregs). Tregitopes are promiscuous MHC Class II T cell epitopes located in the Fc and framework regions of Fab from IgG. In vitro, co-incubation of antigens with Tregitopes in vitro leads to a suppression of effector cytokine and chemokine secretion, reduced proliferation of effector T cells, and expansion of antigen-specific adaptive Tregs (aTregs). In vivo, co-administration of Tregitopes with a wide range of proteins (such as FVIII, thyroid stimulating hormone receptor, ovalbumin, and autoantigens) leads to suppression of T cell and antibody responses to test antigens.

About EpiVax
EpiVax, Inc. is a privately held company based in Providence, Rhode Island. EpiVax uses cutting edge bioinformatics tools (more specifically, immunoinformatics tools such as the EpiMatrix algorithm) to improve the efficacy and safety of vaccines and biologic products (proteins such as Humira, Factor VIII, and Botox). EpiVax’ also has extensive internal programs focused on developing new methods for modulating the human immune response using its Tregitope Technology platform. For more information about EpiVax, please visit www.epivax.com. For more information on the Tregitope technology and EpiVax’ other offerings please contact Jason Del Pozzo at jdelpozzo(at)epivax(dot)com.

###

Read the full story at http://www.prweb.com/releases/2010/05/prweb4043544.htm.


'/>"/>
Source: PRWeb
Copyright©2010 Vocus, Inc.
All rights reserved  

Related biology technology :

1. EpiVax, Inc. forms Collaborative Research Agreement with Roche to Develop Tregitope Technology
2. Research Triangle Area Health Care Collaborative Launches Bridges to Excellence(R) Initiative to Improve Quality and Lower Costs
3. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
4. BioMarin Licenses Technology From Leading Cystic Fibrosis Research Laboratory at the University of California, San Francisco
5. IDM Pharma Names Dr. Jeffrey W. Sherman Chief Medical Officer and Senior Vice President of Research and Development
6. Dawson James Securities Initiates Research Coverage on CryoCor, Inc. (Nasdaq: CRYO) with a Strong Buy Rating and $6.00 Target Price
7. eResearchTechnology to Present at the Thomas Weisel Healthcare Conference 2007 on September 5th
8. The Debiopharm Life Sciences Award Goes to Dr Nusser for his Outstanding Research in Neuroscience
9. Study Published in Clinical Cancer Research Confirms Potential Of Peregrines Bavituximab Combined With Radiation In Lung Cancer
10. Dow AgroSciences and Exelixis Plant Sciences Announce Major Research Collaboration, Asset Purchase to Advance Gene Discovery and Validation
11. Revolutionary Genomics Research Group Opens Boston Office; Provides DNA Evidence in Workers Comp Cases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
EpiVax Research on Tregitopes Wins 2010 AAPS Innovation in Biotechnology Award
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... manufacturing company, today announced several positive developments that position the Company for the ... result of the transaction, Craig F. Kinghorn has been appointed Chairman of the ...
(Date:5/25/2016)... , ... May 25, 2016 , ... ... a Thai delegation at BIO 2016 in San Francisco. Located at booth number ... be available to answer questions and discuss the Thai biotechnology and life sciences ...
(Date:5/25/2016)... ... May 25, 2016 , ... The American Medical ... Office of the National Coordinator for Health IT (ONC) outlining a measurement approach ... data were available when and where it was needed. The organization of health ...
(Date:5/25/2016)... , ... May 25, 2016 , ... Lady had been ... tore her cruciate ligament in her left knee. Lady’s owner Hannah sought the help ... Florida board-certified veterinary surgeon, to repair her cruciate ligament and help with the pain ...
Breaking Biology Technology:
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
(Date:3/31/2016)... BOCA RATON, Florida , March 31, 2016 /PRNewswire/ ... LEGX ) ("LegacyXChange" or the "Company") ... presentation for potential users of its soon to be ... The video ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also ... by the use of DNA technology to an industry ...
Breaking Biology News(10 mins):