Tregitope is a set of regulatory T-cell epitopes found in the Fc region of IgG that induce the activity of the body’s own natural regulatory T cells. When administered in conjunction with other antigens or protein immunogens, the response to these immunogens is diminished and altered if the antigen/immunogens are co-administered with Tregitopes. Preliminary in vitro and in vivo studies indicate that the modification of the immune response is due to the induction of natural T reg cells.
Examples of potentially immunogenic protein therapeutics include erythropoietin and alpha interferon, as well as antibodies that have immunosuppressive and anti-inflammatory properties such as humira and rituximab. Like vaccines, protein therapeutics can engender both cellular and humoral immune responses. Anti-drug antibodies (ADA) may neutralize the therapeutic effects of the drug and/or alter its pharmacokinetics. Since the impact of immunogenicity can be quite severe, regulatory agencies are developing new guidelines for monitoring immunogenicity and drug developers are seeking to reduce immune responses through other means such as by inducing tolerance. The Tregitope technology induces the human body’s natural tolerance mechanisms, reducing the immunogenicity of co-administered proteins. The initial discovery was published in 2008, in the journal Blood, by EpiVax CEO and CIO De Groot and Martin.
EpiVax, Inc. is dedicated to merging in silico, in vitro and in vivo immunology research to generate new therapeutics as well as new vaccines for infectious diseases. T cell epitope mapping, the selection of target peptides from any protein sequence, is a powerful resource for the development of novel protein therapeutics. EpiVax rese
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