Navigation Links
EpiStem Successfully Complete First Year of Mucositis Tests for NIH Biodefence Programme

MANCHESTER, England, September 20 /PRNewswire-FirstCall/ -- EpiStem (LSE: EHP) announced today that it has completed the first year of mucositis efficacy-testing services for potential biodefense drugs, and are about to embark upon an extensive drug screening programme over the coming year.

The National Institutes of Health (NIH) Medical Countermeasures against Radiological and Nuclear Threats (MCART) programme leads the U.S. effort to develop treatments for radiation sickness following a nuclear terrorist attack. EpiStem is a major provider of services to identify novel drugs that can improve the repair of the gastrointestinal (GI) tract following exposure to irradiation. There are currently no medications approved by the FDA to treat this syndrome. EpiStem is an established provider of similar GI assays for oncology supportive care. These assays provide quantitative and mechanistic data to assess the efficacy of novel drug candidates, enabling companies to make informed decisions regarding the progression of their preclinical pipeline.

Dr Tom MacVittie, who co-ordinates the programme at the University of Maryland School of Medicine said: "Gastrointestinal acute radiation syndrome (GI-ARS) is a massive, currently untreatable, problem following high-dose radiation exposure. Agents that mitigate these effects could reduce sickness and hopefully prevent fatalities. The tests performed by EpiStem are also likely to identify agents with oncology supportive care applications - agents that will reduce the severe ulceration and diarrhoea (mucositis) experienced by patients during radio- and chemo-therapy".

Dr Catherine Booth, head of EpiStem's contract research division commented: "After completion of a series of validatory assays, initial studies on first three test drugs have successfully been completed, with approx 10 more with an estimated value of US$0.75m revenue for the Company in the pipeline for the coming year. The programme is forecast to extend over the next 3 years. EpiStem is also now working to gain GLP compliance for the next phase of the project, in order to help the consortium develop drugs for FDA approval in future years".

Other members of the Consortium include the University of Maryland, Baltimore, the University of Illinois at Chicago, Indiana University at Indianapolis, the Armed Forces Radiobiology Research Institute at Bethesda, Fast Track Drugs and Biologics LLC, Aotech, LLC, and Information Management Consultants, Inc.

Additional Information

EpiStem is a biotechnology company commercialising adult stem cells in the areas of oncology and gastrointestinal diseases as well as cosmeceutical applications. EpiStem develops innovative therapeutics and diagnostic biomarkers and provides contract research services to drug development companies. The Group's expertise is focused on the regulation of adult stem cells located in epithelial tissue, which includes the gastrointestinal tract, skin, hair follicles, breast and prostate. EpiStem does not conduct research in the areas of embryonic stem cells or stem cell transplantation.

EpiStem operates two distinct business divisions, Contract Research Services and Novel Therapies.

Contract Research Services

Contract Research Services provides specialised preclinical efficacy testing primarily for drug development companies on a fee for service basis. This division on a standalone basis is cash generative and profitable with a five-year track record of providing testing services to over 72 international company clients primarily in Europe and the United States.

Novel Therapies

Novel Therapies is focused on developing its own innovative therapeutics and diagnostic biomarkers. Through its discovery platform, Novel Therapies has identified 250 potential drug candidates, of which a subset will undergo further evaluation as stem cell regulators for the Group's emerging drug development pipeline. Novel Therapies is also developing its clinical diagnostic biomarker technology.

Combined Business Model

The Group is exploiting its combined business model to advance its own therapeutic candidates to late preclinical stage development. The business model integrates the discovery efforts of Novel Therapies with the efficacy testing assays of its Contract Research Services Division, to identify and characterise new drug candidates. Revenues generated by Contract Research Services will assist in offsetting Novel Therapies' investment requirements for the discovery and development of therapeutics. In February 2007, EpiStem licensed its first drug candidate to a clinical development company. With the validation of the Novel Therapies discovery platform and the achievement of discovery milestones, the Directors believe that additional licensing partnerships will be forthcoming for therapeutics, diagnostics and cosmeceuticals starting in 2008.

For more information please contact:

Matthew Walls

Chief Executive Officer

EpiStem Ltd


Mike Wort, Anna Dunphy

MC Bio-Communications Limited


Thilo Hoffmann

Landsbanki Securities (UK) Limited


SOURCE Epistem Ltd
Copyright©2007 PR Newswire.
All rights reserved

Related biology technology :

1. National Instruments DIAdem -- Complete Your Technical Data Management Framework with Powerful Off-line Analysis, Visualization, and Report Generation
2. Potawatomis complete acquisition of tech firm
3. Sonic Foundry completes $11.25M stock offer
4. Orion Energy completes $5M capital round
5. RedPrairie completes MARC acquisition
6. Metavante completes purchase of check processing firm
7. GE completes $1.2 billion acquisition
8. M & Is Metavante completes Brasfield Corp. acquisition
9. Berbee Data Centers complete audit, certification
10. Metavante completes GHR Systems acquisition
11. Metavante completes TREEV acquisition
Post Your Comments:
(Date:11/25/2015)... 25, 2015 The Global ... a professional and in-depth study on the current ... (Logo: ) , The ... including definitions, classifications, applications and industry chain structure. ... international markets including development trends, competitive landscape analysis, ...
(Date:11/24/2015)... ... November 24, 2015 , ... The United States Golf Association (USGA) ... USGA Green Section Award. Presented annually since 1961, the USGA Green Section Award recognizes ... with turfgrass. , Clarke, of Iselin, N.J., is an extension specialist of ...
(Date:11/24/2015)... Nov. 24, 2015 /CNW/ - iCo Therapeutics ("iCo" or ... financial results for the quarter ended September 30, ... Canadian dollars and presented under International Financial Reporting ... ," said Andrew Rae , President ... iCo-008 are not only value enriching for this ...
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris Inc. ... IIROC on behalf of the Toronto Stock Exchange, confirms ... there are no corporate developments that would cause the ... --> --> About Aeterna Zentaris ... . --> Aeterna Zentaris is a specialty ...
Breaking Biology Technology:
(Date:11/9/2015)... DUBLIN , Nov. 09, 2015 /PRNewswire/ ... announced the addition of the "Global ... to their offering. --> ... "Global Law Enforcement Biometrics Market 2015-2019" ... Research and Markets ( ) ...
(Date:10/29/2015)... Oct. 29, 2015   MedNet Solutions , an ... spectrum of clinical research, is pleased to announce that ... Association (MHTA) as one of only three finalists for ... – Small and Growing" category. The Tekne Awards honor ... shown superior technology innovation and leadership. ...
(Date:10/29/2015)...  Connected health pioneer, Joseph C. Kvedar , ... health and wellness, and the business opportunities that arise ... Internet of Healthy Things . Long before health ... Dr. Kvedar, vice president, Connected Health, Partners HealthCare, was ... care from the hospital or doctor,s office into the ...
Breaking Biology News(10 mins):