Navigation Links
Enzyme promotes fat formation
Date:10/11/2007

The enzyme TPPII may contribute to obesity by stimulating the formation of fat cells, suggests a study in EMBO reports this week. The enzyme, TPPII, has previously been linked to making people feel hungry, but Jonathan Graff and colleagues now show that it may be even more deeply involved in causing obesity.

The team found that TPPII actually stimulated the formation of fat cells in worms and mammalian cells and that by reducing it, fat stores decreased. Mice with lower levels of TPPII were thinner than their wild type littermates, although their food intake was comparable.

The authors hope that TPPII could be exploited as a drug target to help fight increasing levels of obesity; inhibiting the enzyme would both increase feelings of fullness after eating and decrease build up of fat cells.

Around 40 million Americans are obese and the UK Government predicts that 12 million adults in the UK will be obese by 2010 if nothing is done. Obesity is responsible for 70% of cardiovascular diseases and 80% of type II diabetes and represents a serious health risk and financial drain.


'/>"/>

Contact: Jonathan Graff
jon.graff@utsouthwestern.edu
214-648-1481
European Molecular Biology Organization
Source:Eurekalert

Page: 1

Related biology technology :

1. The Best Enzyme for the Toughest PCR Challenges Improved with New Hot-Start Feature
2. Comparing Fidelity and Performance of Proofreading PCR Enzymes
3. pfuturbo DNA Polymerase: A High-Performance, High-Fidelity Enzyme Ideal for PCR Cloning
4. Greater Amplification Specificity with New Hot Start PCR Enzyme
5. Enzyme Immunoassay for Studying Intracellular Levels of cAMP
6. Improve Amplification Specificity with Hot Start PCR Enzyme
7. Choice of RT-PCR Enzymes
8. Properties of PCR Enzymes
9. Select the Optimal Enzyme for RT-PCR
10. Enzyme Purification With the Econo-Pac Q Cartridge
11. Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3, 5 monophosphate and its validation for pharmacological screening at G protein-coupled receptors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 17, 2015 /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: SQD; ... that develops and commercializes proprietary technologies and products ... it has received approval from the TSX Venture ... common share purchase warrants ("the Warrants") of the ... Company,s May 2013 private placement financing. ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Global ... the GTCbio Stem Cell Summit 2015 April 27 - ... the latest developments in all areas of stem cell ... of stem cells and regenerative medicine. , The ... trials, as well as translational research in stem cell ...
(Date:4/16/2015)... Bythewood, South Carolina (PRWEB) April 17, 2015 ... solutions and steam system services, released their newly ... 2015. The customer facing website effectively promotes ... proposition. , All the information that a ... training, steam system services, company capabilities, industries serviced, ...
(Date:4/16/2015)... 2015 Cytokinetics, Incorporated (Nasdaq: CYTK) announced ... results on Thursday, April 30, 2015 at 4:00 PM ... host a conference call at 4:30 PM Eastern Time ... outlook for the future. , The conference call will ... homepage and in the Investor Relations section of Cytokinetics’ ...
Breaking Biology Technology:SQI Diagnostics to Extend Warrant Expiry 2SQI Diagnostics to Extend Warrant Expiry 3Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 3Spirax Sarco website has a new look 2Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3
... Inc.,(Nasdaq: ONTY ) (TSX: ONY) (the "Company") ... in a Phase 1b clinical trial of PX-12 ... proprietary small molecule,inhibitor of thioredoxin, a protein that ... survival and drug resistance of,many cancers., The ...
... and present a poster on proprietary siRNA ... targeting and ... Pharmaceuticals, Inc., a,development-stage pharmaceutical company discovering and developing novel,RNA ... Cambridge Healthcare Institute,s 9th Annual Beyond,Genome Conference on June ...
... Calif., June 10 DURECT Corporation,(Nasdaq: DRRX ... (NDA) for,Remoxy(TM) (ORADUR(TM)-based oxycodone) has been submitted to ... investigational drug, is a long,acting oral formulation of ... on DURECT,s ORADUR technology, Remoxy is designed to ...
Cached Biology Technology:Oncothyreon initiates Phase 1b trial of PX-12 in patients with advanced metastatic cancer 2Oncothyreon initiates Phase 1b trial of PX-12 in patients with advanced metastatic cancer 3Quark Pharmaceuticals to Participate in 9th Annual Beyond Genome Conference 2Quark Pharmaceuticals to Participate in 9th Annual Beyond Genome Conference 3New Drug Application Submitted for Remoxy(TM) (ORADUR(TM)-Based Oxycodone) 2New Drug Application Submitted for Remoxy(TM) (ORADUR(TM)-Based Oxycodone) 3New Drug Application Submitted for Remoxy(TM) (ORADUR(TM)-Based Oxycodone) 4New Drug Application Submitted for Remoxy(TM) (ORADUR(TM)-Based Oxycodone) 5
(Date:3/24/2015)... and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has announced ... 2015-2019" report to their offering. The ... at a CAGR of 23.5 percent over the period ... and the growth prospects of the Global Iris Recognition ... size, the report considers the revenue generated from sales ...
(Date:3/24/2015)... 24, 2015   NexID Biometrics LLC, whose ... needs, today announced the beginning of shipments of version ... The company, based in Potsdam, N.Y. ... Connect:ID Expo, which began here today at the Walter ... 2.0 of its SDK boosts the accuracy rate range ...
(Date:3/23/2015)... -- SoundView Technology Group issues a new research update following ... smart wallet. SoundView was one of the selected user groups to ... Wocket in multiple scenarios and outlets. Soundview ... making both debit and credit card payments.  ... company meets their plans in 2015, it would push our ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... German . , Together with colleagues from ... for Allergy and Environment of the Technische Universitt Mnchen, ... major gene for allergic diseases. The gene was localized ... genome at the Helmholtz Zentrum Mnchen. The newly discovered ...
... of St. Andrews, United Kingdom, have helped determine why relearning ... cause a recollection of other associated, previously learned information. ... the learned information is forgotten. Details are published August ... When one learns a language and then doesn,t use ...
... 2008)-- U.S. Energy Secretary Samuel Bodman and Enrique Santacana, ... keynote speakers during GridWeek 2008 in Washington. ... and International Trade Center, is an annual gathering of ... major partner of GridWeek 2008. Bodman and ...
Cached Biology News:Munich researchers discover key allergy gene 2Energy secretary, IEEE-member industry leader to deliver keynote addresses during GridWeek 2008 2
Reported to support murine B lymphocytes, hematopoietic tissue from bone marrow, B cells stimulated with lipopolysaccharide, T lymphocytes, and a variety of hybrid cells....
... Many modifications of Eagle's ... the original formulation. The most ... Modified Eagle's,Medium. DME is a ... Eagle [MEM] that contains a ...
... Hollandes is a fixative useful for ... fixation. It is stable and will decalcify ... with Hollande's can be stained successfully with ... the solution stabilizes red blood cell membranes ...
... Gas Chromatograph/Mass Spectrometer, utilizing many of ... Plus, offers high throughput and excellent ... performance-to-cost ratio. Like the GCMS-QP2010 Plus, ... velocity for optimum separation, 20 temperature ...
Biology Products: