Navigation Links
EntreMed's Kinase Inhibitor, ENMD-2076, Presented During AACR Special Session
Date:4/14/2008

New Drugs on the Horizon Session Highlights New Small Molecule Drug

Candidates

ROCKVILLE, Md., April 14 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced the presentation of preclinical and mechanism of action data for its selective kinase inhibitor, ENMD-2076. On Sunday, April 13, 2008, Mark R. Bray, Ph.D., Vice President, Research, gave an oral presentation during the "New Drugs on the Horizon 2" symposium at the American Association for Cancer Research (AACR) Annual Meeting being held this week in San Diego, California.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO )

During the presentation, Dr. Bray highlighted ENMD-2076's unique combination of antiangiogenic, cell cycle, and antiproliferative activities. In preclinical studies, ENMD-2076 demonstrated potent activity against Aurora A and tyrosine kinases linked to promoting cancer and inflammatory diseases. ENMD-2076 acts through multiple pathways resulting in antiproliferative activity and the inhibition of angiogenesis. ENMD-2076 has demonstrated substantial, dose-dependent efficacy as a single agent in multiple xenograft models, including tumor regression in breast, colon, and leukemia models. ENMD-2076 is an orally active, multi-kinase inhibitor that has shown an acceptable toxicity profile in multiple preclinical studies without cardiovascular effects.

Dr. Bray commented on the presentation, "We are fortunate to have been selected to showcase the potent activity of ENMD-2076 during t
'/>"/>

SOURCE EntreMed, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. EntreMed Announces FDA Acceptance of IND Application for Aurora Kinase/Angiogenesis Inhibitor, ENMD-2076
2. ImaRx Therapeutics Receives Urokinase Lot Release Approval With Extended Expiration Dating
3. New Oral MEK Inhibitor, RDEA119, Shows Favorable Anti-Tumor Properties
4. Kosans Hsp90 Inhibitor, Tanespimycin, Shows 55% Clinical Benefit in Patients With Trastuzumab-Refractory Metastatic Breast Cancer
5. Study Shows Coronado Biosciences Bcl-2 Inhibitor, Apogossypol, is More Efficacious, Less Toxic than Gossypol in Animal Models
6. Three Studies by Independent Scientists Highlighting Pressure Cycling Technology (PCT) to be Presented this Week at the British Mass Spectrometry Societys 29th Annual Meeting
7. Survival Data Presented From Phase II Study of Investigational Drug ZD4054 in Hormone-Resistant Prostate Cancer Patients
8. New Data Presented on Immunocytokine Fusion Protein Further Supports Broad Anti-Cancer Potential Of Peregrines Anti-PS Technology Platform
9. Results of Colon Cancer Study Utilizing Pressure Cycling Technology (PCT) Presented at the American College of Gastroenterology Annual Scientific Meeting
10. Kuvan, Naglazyme and Aldurazyme Data to Be Presented at the 57th Annual Meeting of the American Society of Human Genetics
11. Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2013)... 10, 2013  Vestagen Technical Textiles, Inc., today ... in an extension of its recent financing round. Existing ... extension by new investors Sofinnova HealthQuest Capital and ... raised by Vestagen in this financing round to ... this year. In conjunction with the financing extension, ...
(Date:12/10/2013)... (PRWEB) December 10, 2013 Tunnell ... who served in the U.S. Food and Drug ... joined the firm as a Managing Consultant, Quality ... at the FDA enables him to provide our ... good manufacturing practices, preparing for inspections, and mitigating ...
(Date:12/10/2013)... Colleges and universities nationwide are ... pre-collegiate summer program designed to ignite interest in ... 10th and 11th grade students from underrepresented populations. ... Program (AEOP) , UNITE helps prepare students to ... and related STEM fields. , Administered by the ...
(Date:12/9/2013)... Case Western Reserve University and University of Kansas Medical ... reach through a narrow opening and grasp foodusing a ... , Ultimately, the team hopes to develop a device ... in humans. There is no such commercial treatment for ... Iraq, who suffer traumatic brain injuries (TBI), or the ...
Breaking Biology Technology:Protective Apparel Innovator Vestagen Adds $7.3 Million In Financing Extension, Bringing Total Raised To $15.5 Million 2Protective Apparel Innovator Vestagen Adds $7.3 Million In Financing Extension, Bringing Total Raised To $15.5 Million 3Protective Apparel Innovator Vestagen Adds $7.3 Million In Financing Extension, Bringing Total Raised To $15.5 Million 4Protective Apparel Innovator Vestagen Adds $7.3 Million In Financing Extension, Bringing Total Raised To $15.5 Million 5Anthony A. Charity Joins Tunnell Consulting 2U.S. Army Seeks Colleges and Universities to Host Summer STEM Programs 2U.S. Army Seeks Colleges and Universities to Host Summer STEM Programs 3Neural prosthesis restores behavior after brain injury 2
... Aug. 23 Amnis Corporation announced today the,release ... including the,Commercial release of a multilaser capability and ... extending the depth of field well beyond,conventional optical ... with the flexibility of,adding two additional lasers including ...
... FDA Approved Product Will Accelerate Growth of Pain ... Inc. (Nasdaq:,CEPH) announced today it has signed an ... (cyclobenzaprine hydrochloride extended-release,capsules) from ECR Pharmaceuticals, a privately ... and 30 mg) were approved in February 2007 ...
... Genetic Biomarker Portfolio to Have Important Role in Targeted Drug ... Purchase Expands European Presence, Advances PGxHealth Test ... ... Pharmacogenomics Services, NEWTON, Mass., Aug. 23 Clinical Data, Inc.,(Nasdaq: ...
Cached Biology Technology:Amnis Announces the Release of Multiple Upgrades to the ImageStream(R) System 2Cephalon, Inc. Announces Agreement to Acquire AMRIX, A Once-Daily Extended-Release Muscle Relaxant 2Cephalon, Inc. Announces Agreement to Acquire AMRIX, A Once-Daily Extended-Release Muscle Relaxant 3Cephalon, Inc. Announces Agreement to Acquire AMRIX, A Once-Daily Extended-Release Muscle Relaxant 4Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio 2Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio 3Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio 4Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio 5Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio 6
(Date:12/9/2013)... The supply of shellfish we buy at the supermarket ... and more acidic due to changing climate., A team ... understand how these changes in our oceans will affect ... to marine biodiversity., Currently scientists do not fully understand ... produce their shells, or how a change in environment ...
(Date:12/9/2013)... new study shows that high school athletes playing at ... sea-level, a phenomenon attributed to physiological changes in the ... skull. , "This is the first time any research ... PhD, associate professor of epidemiology at the Colorado School ... appears that when you are at altitude there may ...
(Date:12/9/2013)... Sandia National Laboratories researchers have devised a novel ... (MOF) materials, a development that could have profound ... conversion and energy storage. , A paper to ... Conductivity in Metal-Organic Framework Thin-Film Devices," debuts in ... Express. The paper co-authored by a group ...
Breaking Biology News(10 mins):Ambitious science program will aid fishing industry and monitor effects of climate change on Europe's shellfish 2Study shows first link between altitude and concussion 2Pioneering path to electrical conductivity in 'tinker toy' materials to appear in Science 2Pioneering path to electrical conductivity in 'tinker toy' materials to appear in Science 3Pioneering path to electrical conductivity in 'tinker toy' materials to appear in Science 4
... the Industrial Revolution, over half of all the CO2 produced ... making pH drop faster than any time in the last ... shown that this causes fish to lose their sense of ... Letters shows that fish hearing is also compromised. ...
... patterns invisible to the human eye onto a special class ... devices in areas ranging from drug delivery to solar cells. ... described in the cover article of the May issue of ... works with materials that are riddled with tiny voids that ...
... the world today agreed at a meeting in Canada to ... in leadership related to global water issues. Saying ... say the panel will work to elevate the issue,s political ... The 20 members of the InterAction Council attending this ...
Cached Biology News:Ocean acidification leaves clownfish deaf to predators 2Stamping out low cost nanodevices 2Stamping out low cost nanodevices 3Void in leadership on world water crisis cited by 20 former heads of government 2
... gel systems used gasketed gel trays. Turn the tray ... Turn it back and run the gel - its ... & Cast tray is UV transparent. Each tray accommodates ... tray and one in the center. This allows you ...
The Holten Safe 2010 Class II Biological Safety Cabinets provide the most ergonomical working condition of comfort while incorporating the latest technology for safety, efficiency and performance....
... is a dedicated fluorometer with ... kinds of assays in industrial ... clinical applications. Cell biology, immunology ... important application areas. Robot-friendly hardware ...
... MSC series of Class II Biological ... and certification to the world's highest ... that the cabinets cannot be adjusted ... lighting, low noise and arm rest ...
Biology Products: