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EntreMed Receives Nasdaq Deficiency Notice
Date:4/4/2008

itate investment in the Company by a broader group of institutional investors. As a result, there may be less volatility in the Company's stock price, which would enable the Company to raise funds at a lower cost to finance its ongoing research, product development, and clinical trials, and to meet other business objectives unrelated to NASDAQ listing rules.

EntreMed, Inc., President and CEO, James S. Burns, commented on the notification, "Micro-cap biotech companies, including ours, have experienced substantial downward pressure on stock prices. Our stock price has fallen in line with other oncology companies at our stage of development, a situation that I strongly believe is due to market weakness rather than any fundamentals within EntreMed specifically. We are committed to bringing the Company back into compliance, investing behind our most promising programs, managing our cash conservatively, and meeting our milestones."

Mr. Burns continued, "The deficiency notification does not immediately affect our NASDAQ listing, nor does it impact our 2008 plan to invest behind our most promising programs. Our pipeline has a sharper focus and we are devoting increased time and resources to partnering one or several of our programs. Our goal is to continue improving the quality of our pipeline, de-risk the Company, and build shareholder value."

About EntreMed

EntreMed, Inc. is a clinical-stage pharmaceutical company developing therapeutic candidates primarily for the treatment of cancer and inflammation. MKC-1 is currently in multiple Phase 2 clinical trials for cancer. MKC-1 is an oral cell-cycle regulator with activity against the mTOR pathway. ENMD-1198, a novel antimitotic agent, is in a Phase 1 study in advanced cancer patients and ENMD-2076, a selective kinase inhibitor, is expected to begin a Phase 1 study in 2Q08. The Company also has an approved IND application for Panzem(R) in rheumatoid arthritis. EntreMed's goal is to develop and comm
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