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EntreMed Announces FDA Acceptance of IND Application for Aurora Kinase/Angiogenesis Inhibitor, ENMD-2076
Date:1/3/2008

in multiple preclinical models including both solid tumors and hematological cancers. As such, we plan to initiate several clinical studies with ENMD-2076 that include Phase 1 trials in both solid and hematological cancers in 2008."

James S. Burns, EntreMed President & CEO commented, "The IND for ENMD-2076 represents an important milestone for EntreMed. This compound has shown significant single-agent activity, including tumor regression in multiple animal models. Moving ENMD-2076 forward into clinical development is consistent with our strategy of investing preferentially behind small molecule, orally-administered, multi-mechanism product candidates with potent single-agent antitumor activity and strong intellectual product coverage. Our goal is to commence clinical trials for ENMD-2076 and, in parallel, seek a development partner to help us accelerate the development of what I believe is an exciting oncology opportunity for EntreMed."

About EntreMed

EntreMed, Inc. is a clinical-stage pharmaceutical company developing therapeutic candidates primarily for the treatment of cancer and inflammation. MKC-1 is currently in multiple Phase 2 clinical trials for cancer. MKC-1 is an oral cell-cycle regulator with activity against the mTOR pathway. Panzem(R) NCD is currently in multiple Phase 2 trials for cancer. Additionally, ENMD- 1198, a novel tubulin-binding agent, is in Phase 1 studies in advanced cancers. Panzem(R) (2-methoxyestradiol) is also in multiple Phase 2 studies in oncology patients. The Company has approved IND applications for Panzem(R) in rheumatoid arthritis, and ENMD-2076, a dual-acting Aurora-angiogenesis inhibitor, for cancer. EntreMed's goal is to develop and commercialize new compounds based on the Company's expertise in angiogenesis, cell-cycle regulation and inflammation - processes vital to the treatment of cancer and other diseases, such as rheumatoid arthritis. Additional information about EntreMed is available on the Company
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