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EntreMed Announces 2008 Corporate and Clinical Program Priorities
Date:3/13/2008

trial (4Q08).

-- ENMD-2076 is an oral selective kinase inhibitor with a unique kinase

profile, including antiproliferative activity and inhibition of

angiogenesis. ENMD-2076 has demonstrated potent antitumor activity as a

single agent in multiple preclinical models, including tumor regression

in breast, colon, and leukemia models without cardiovascular effects.

ENMD-2076 is a unique-in-class compound that inhibits both Aurora A and

growth factor receptors critical to angiogenesis.

-- EntreMed's IND has been accepted by the FDA and a Phase 1 study in

solid tumors is expected to enroll patients in early 2Q08. EntreMed has

been selected for an oral presentation on ENMD-2076 during the American

Association for Cancer Research's "Drugs on the Horizon" symposium to

be held during the AACR annual meeting in April. ENMD-2076 milestones

for 2008 include initiating a Phase 1 trial in solid tumors (1Q08);

initiating a Phase 1 trial in hematological tumors (3Q08/4Q08); and

entering into a development alliance (2H08/1H09).

-- EntreMed plans to discontinue development of 2ME2 (Panzem(R) NCD) for

oncology. Modest antitumor activity has been shown across most of the

clinical studies, yet there is not a clear development path that would

narrow the indications for larger randomized studies. Additional trial

costs, the high doses required for use in oncology, and

manufacturing/process development expenditures would together require

the commitment of a disproportionate amount of resources and limit

clinical development efforts on the remainder of the pipeline. Patients

still on clinical oncology trials, however, will continue to receive

Panzem(R) NCD.

-- EntreMed plans to move 2ME2 forward in rheumatoid arthritis based on

the knowledge gained from the oncolo
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SOURCE EntreMed, Inc.
Copyright©2008 PR Newswire.
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