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Entinostat Demonstrates Activity in Hodgkin's Lymphoma
Date:12/11/2011

WALTHAM, Mass., Dec. 11, 2011 /PRNewswire/ -- Syndax Pharmaceuticals, Inc. announced today that data from ENGAGE 501, a multicenter, phase 2 study, demonstrated entinostat, a novel, oral small molecule inhibitor of class I histone deacetylases, showed activity as a single agent in patients with relapsed or refractory Hodgkin's lymphoma (HL).  This data is being presented today, December 11, from 6:00 to 8:00 PM PT at the American Society of Hematology Annual Meeting and Exposition in San Diego.  

"Showing activity in this hard-to-treat patient population, demonstrates potential for entinostat to treat Hodgkin's lymphoma," said Anas Younes, MD, professor, department of lymphoma/myeloma, division of cancer medicine, The University of Texas MD Anderson Cancer Center. "These results are consistent with what has been seen with other HDAC inhibitors with a lower rate of toxicity warranting further study of entinostat particularly in combination strategies and at an earlier stage of disease."

Highlights of the data include:

  • Antitumor activity observed in HL patients progressing after SCT with bulky disease in about a third of patients within two cycles of therapy
  • Progression-free survival (PFS) showed durable responses in bulky disease patients
  • Overall survival (OS) was an exploratory endpoint with data that is still maturing
  • Entinostat was well tolerated and the safety profile is consistent with previous studies allowing for future combination treatments.

"We are pleased to see that the results of ENGAGE 501 provide evidence of single-agent activity for entinostat in Hodgkin's lymphoma," said Joanna Horobin, MD, president and chief executive officer of Syndax.  "Given this data combined with the recently reported '/>"/>

SOURCE Syndax Pharmaceuticals, Inc.
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