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Entia Receives Notices of Allowance for its Ergothioneine and Genetic Transporter Patents from the United States, Canada, and Israel
Date:4/2/2013

ogne in 2010 and Dr. Grundemann currently serves on Entia's Scientific Advisory Board.

Found in naturally high concentrations almost exclusively in mushrooms and other fungi, Ergothioneine is transferred directly from these sources into the soil, where it is taken up by plants and grazing mammals.  For thousands of years, our hunter/gatherer genetics have relied on this process to maintain adequate levels of Ergothioneine to prevent or delay the onset and progression of disease.  Entia theorizes introduction of modern agricultural practices in the past century, such as the heavy use of chemical fertilizers, herbicides, pesticides, and over tilling of the soil, has been gradually eradicating mushrooms from our farmland and depleting Ergothioneine from the food supply.   During this same period, our dietary habits have been changing,  which Entia believes is further accelerating deficiency in the general population and may be a contributing factor in the dramatic increases we are now seeing in diabetes, arthritis, neurodegenerative, and other debilitating diseases.  This deficiency theory is supported by human blood testing conducted in the late 1920s (Salt, 1931) that showed "normal" Ergothioneine levels nearly double those found by Pennsylvania State University in 2010 (Weigand-Heller, 2012).

Dr. Solomon Snyder of Johns Hopkins University School of Medicine has suggested that Ergothioneine is as potent as glutathione and because of its dietary origin and the toxicity associated with its depletion, it may represent a new vitamin whose physiologic roles include antioxidant cytoprotection.  Dr. Snyder further believes that the high density of Ergothioneine within mitochondria implies a unique role in protecting mitochondrial DNA from damage induced by free radicals and reactive oxygen species (Snyder, 2009).  Mitochondria are cytoplasmic organelles responsible for life a
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