Navigation Links
Enobia Completes Target Enrollment in Clinical Trial for Infantile Hypophosphatasia
Date:3/3/2009

MONTREAL, March 3 /PRNewswire/ -- Enobia Pharma, an emerging Canadian biotech company focused on developing novel therapeutics for serious bone disorders, today announced completion of target enrollment in its pilot clinical trial in infants suffering from a severe form of hypophosphatasia. Enobia is investigating Enzyme Replacement Therapy (ERT) with ENB-0040 for the treatment of this rare and often crippling genetic bone disorder for which there is no approved treatment.

ENB-002-08 is an open-label, six month study evaluating safety, efficacy and pharmacokinetics of subcutaneous ENB-0040 in hypophosphatasia infants with severe rickets and respiratory compromise. Six severely affected infants from the EU, US and the Middle East will be treated at approved sites in the US, Canada, UK and the United Arab Emirates. Key efficacy outcomes include improvement in rickets and clinical manifestations of the disease. Results from the trial will be presented at the Endocrine Society meeting in June.

A Phase I study, which evaluated safety, tolerability and pharmacokinetics of ENB-0040 in adults with hypophosphatasia was completed in December of 2008. Results of that study will be presented at the American College of Medical Genetics in March.

"Everyone involved in the clinical program is extremely pleased with our progress," said Robert Heft, CEO of Enobia. "Since filing an IND only eight months ago, we have completed a Phase I study and enrolled this Phase I/II study in infants. We believe ENB-0040 will be shown to significantly improve the devastating skeletal manifestations of hypophosphatasia and may potentially be life-saving therapy for those suffering from the lethal form of the disease."

Additional trials are planned. If interested in learning more, contact '/>"/>

SOURCE Enobia Pharma Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Enobia Pharma Raises $40.1 Million Series B Financing
2. Zenobia Therapeutics, Inc. Begins Operations as a Fragment-Based Lead Discovery Company
3. Zenobia Therapeutics, Inc. Receives Michael J. Fox Foundation for Parkinsons Research Award for Work on PD-implicated Protein LRRK2
4. Enobia Pharma Presents PreClinical Data Showing ENB-0040 Significantly Improved Survival and Healed Skeletal Manifestations of Severe Hypophosphatasia in Mice
5. H2Diesel Completes 3 Million Gallon Per Year Pilot Facility
6. AEterna Zentaris completes management team with the appointment of Chief Medical Officer
7. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
8. Carrington Completes $8 Million Financing
9. Proteon Therapeutics Completes $12 Million Financing and Hires CFO
10. New Brunswick Scientific Completes Merger Transaction with Eppendorf
11. Kiwa Bio-Tech Completes 1st Stage of Shandong Factory Upgrading
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 23, 2014 On Friday, December ... 83, the Omnibus and Continuing Resolution Appropriations Act ... hydrocephalus a condition eligible to receive funding through ... by the Department of Defense (DoD). The Hydrocephalus ... on Capitol Hill, is celebrating this victory for ...
(Date:12/24/2014)... The report expects global cell isolation and expansion market ... a carefully analyzed data about the vital drivers, restraints, ... Full Copy of Report @ http://bit.ly/1yUxy0T , ... expansion will keep witnessing growth at an impressive CAGR ... driven by rapid technological advancements, government funding and investments, ...
(Date:12/24/2014)... -- PharmaBoardroom,s new report, , Healthcare ... for free download , digs deep into this vibrant ... the sector today. One area where ... developing a homegrown pharmaceutical manufacturing base, even if the government,s ... way off. A cursory comparison with neighboring Morocco ...
(Date:12/22/2014)... Brussels (PRWEB) December 22, 2014 The ... the global leader of technical training across the life ... Clinical Data Management (SCDM) to provide the organization's ... certification programs —providing access to the more than 350 ... SCDM members with 10% off when registering for a ...
Breaking Biology Technology:Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3
... solutions for biofuels, biochemicals and textile processingPALO ALTO, ... Yesterday, Genencor, a division of Danisco ... Area Research and Development headquarters to a group ... showcased recently announced collaborations for developing sustainable fuels, ...
... 20 Solos Endoscopy, Inc. (Pink Sheets: SNDY) ... signed an agreement with Lifeline Biotechnologies, Inc. (Pink ... product line to Lifeline Biotechnologies for a combination ... Solos Endoscopy originally purchased the products from ...
... 20, Shire plc (LSE: SHP, NASDAQ: SHPGY ... U.S. District Court of the Southern District of,New York ... (collectively "Mylan") for infringement of Shire,s,patent: U.S. Patent No. ... lawsuit was filed in response to an Abbreviated New ...
Cached Biology Technology:Genencor Shows How Industrial Biotech Breakthroughs Contribute to the New Green Economy 2Genencor Shows How Industrial Biotech Breakthroughs Contribute to the New Green Economy 3Solos Endoscopy, Inc. Sells Ovascope and Mastascope Product Line to Lifeline Biotechnologies, Inc. 2Shire Files Lawsuit Against Mylan for Infringement of FOSRENOL(R) (Lanthanum Carbonate) Patent 2Shire Files Lawsuit Against Mylan for Infringement of FOSRENOL(R) (Lanthanum Carbonate) Patent 3
(Date:11/21/2014)... November 18, 2014 According to ... by Systems (Video, RFID, Access Control, Intrusion Detection, Parking ... Banks, Government), Component Service Geography - Global Forecasts to ... is projected to be around $25 Billion in 2014 ... growing at a CAGR of 8.69%. Browse ...
(Date:11/21/2014)... 20, 2014 Strict laws against distracted driving ... the North American and European automotive sector towards gesture ... recognition systems that are intuitive and able to retrieve ... industry. New analysis from Frost & ... in Europe and ...
(Date:11/21/2014)...   Atmel® Corporation (NASDAQ: ATML ... technology solutions, today launched the industry,s first family of ... V cc range from 1.7V to 5.5V. The ... 2 C bus communication speeds, and are available with ... ideal for consumer, industrial, computer, and medical applications. ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... products are in the solid dosage form. Particulate ... include crystallization; drying, granulation, and coating; tablet compaction; ... other particulate processes are used for the large-scale ... dry powder inhalants for public consumption. As such, ...
... industries. They focus light to zap tumors and send digital ... But the physical length of an ordinary laser cannot be ... which limits its application in many industries. Now the Spaser, ... can be as small as needed to fuel nano-technologies of ...
... Newly released findings of a multinational survey ... (IOF) show clear disparities between patients, and doctors, ... 13-country survey of 844 postmenopausal patients over 55 ... between patient and doctor understanding of the emotional ...
Cached Biology News:Particulate Processes in the Pharmaceutical Industry III 2Particulate Processes in the Pharmaceutical Industry III 3Particulate Processes in the Pharmaceutical Industry III 4Particulate Processes in the Pharmaceutical Industry III 5Particulate Processes in the Pharmaceutical Industry III 6The 'Spaser' heats up laser technology 2Link between fracture prevention and treatment adherence not fully understood by patients 2
Thermo Forma provides an array of accessory Racks for the Cryo/CryoPlus 16" Diameter storage system. To maximise inventory capacity a Jumbo Arrowhead configuration is recommended. You may choose betw...
... The Forma Incubated Console Orbital ... with class-leading ergonomics, unequalled programming power. ... prevents vibration, allowing the unit to ... A patented HEPA filtration system reduces ...
... shakers combine high durability and capacity with ... heavy-duty mechanism prevents vibration, allowing the unit ... Every other part, from the large rubber ... machined aluminum platform is designed to last ...
The Holten mini vertical flow workbench provides a particle-free environment for sample protection against airborne contaminants....
Biology Products: