Navigation Links
Engineers use short ultrasound pulses to reach neurons through blood-brain barrier
Date:9/19/2011

New York, NYDATE TK, 2011Columbia Engineering researchers have developed a new technique to reach neurons through the blood-brain barrier (BBB) and deliver drugs safely and noninvasively. Up until now, scientists have thought that long ultrasound pulses, which can inflict collateral damage, were required. But in this new study, the Columbia Engineering team show that extremely short pulses of ultrasound waves can open the blood-brain barrierwith the added advantages of safety and uniform molecular delivery and that the molecule injected systemically could reach and highlight the targeted neurons noninvasively.

The study, led by Elisa Konofagou, associate professor of biomedical engineering and radiology, will be published in the online Early Edition of the Proceedings of the National Academy of Sciences the week of September 19, 2011.

"This is a great step forward," says Konofagou. "Devastating diseases such as Alzheimer's and Parkinson's that affect millions of people are currently severely undertreated. We hope our new research will open new avenues in helping eradicate them."

Highly specific delivery of drugs to human organs is essential for the effective treatment of many diseases. But the brain presents a difficult problem: it has a unique vascular systemthe blood-brain barrierthat acts as a closed door to prevent the entry of foreign molecules. While it protects the brain from potentially toxic substances, it also prevents the delivery of therapeutic drugs to the brain. Because many molecules cannot cross the BBB, available treatments for patients with neurological disorders have been severely limited. Konofagou and her team are focused on getting the door opened enough to safely reach those cells that need to be treated.

Konofagou and her team have designed a focused ultrasound method that can target only the area of the hippocampus that is affected in early Alzheimer's. In this study, they administered microbubbles to
'/>"/>

Contact: Holly Evarts
holly@engineering.columbia.edu
212-854-3206
Columbia University
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Engineers discover nanoscale balancing act that mirrors forces at work in living systems
2. Nanoengineers invent new biomaterial that more closely mimics human tissue
3. Engineers create vibrant colors in vertical silicon nanowires
4. MIT engineers devise new way to inspect materials used in airplanes
5. Princeton engineers make breakthrough in ultra-sensitive sensor technology
6. Seeing in stereo: Engineers invent lens for 3-D microscope
7. Engineers grow nanolasers on silicon, pave way for on-chip photonics
8. Bioengineers develop bacterial strain to increase ethanol biofuel production
9. Rensselaer mechanical engineers win first place at ASME student manufacturing design competition
10. Engineers make artificial skin out of nanowires
11. UCLA chemists, engineers achieve world record with high-speed graphene transistors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... e2b teknologies , a premier Sage ... Ohio, today announced a leading independent multi-specialty physician group ... to the latest version of Sage 100 ERP ... its kind in the region, the organization has an ... efficiency and data accessibility are paramount to their ongoing ...
(Date:3/4/2015)... BALTIMORE , March 4, 2015 The ... of its 2015 Fellows in the Emerging Leaders in ... fostering future leaders in the field of biosecurity, UPMC ... biosecurity from a wide array of backgrounds, including biological ... private sector. "With the vision and ...
(Date:3/4/2015)... , March 4, 2015 /CNW/ - Resverlogix ... it has completed a collaborative research program ... analytics.  Using Fast Collective Evolution Technology (FACET), ... including all measurements obtained from each of ... Phase 2 clinical trials ASSERT, SUSTAIN and ...
(Date:3/4/2015)... South Korea , March 4, 2015 ... biopesticide company, in August of last year. As part ... Kyung Bon Koo continuing his role as ... , President of Vegalab S.A., will work alongside Koo ... Photo - http://photos.prnewswire.com/prnh/20150303/179218 ...
Breaking Biology Technology:Physician Group Practice Chooses e2b teknologies to Support Its Upgrade to Sage 100 ERP 2014 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 2Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 4Korean Government Program Supports Vegalab's Research and Development 2Korean Government Program Supports Vegalab's Research and Development 3
... PDL BioPharma, Inc. (PDL, the Company) (Nasdaq: ... separate privately negotiated exchange agreements under which it will retire ... Convertible Senior Notes due February 15, 2012 (the 2012 Notes). ... Notes will receive $92.0 million in aggregate principal of new ...
... BOSTON, Oct. 27 BioRadar™ software correctly predicted the ... ( http://www.replikins.com , Replikins Press, 2008). The same rise ... time in the H5N1 (Bird Flu) virus, may similarly ...   Specifically, BioRadar™ analyzed two separate Replikins* ...
... a lot of waste products, but one of these, eggshells, ... the International Journal of Global Warming this month. ... have demonstrated that the membrane that lines an eggshell can ... gas carbon dioxide from the atmosphere. The carbon dioxide thus ...
Cached Biology Technology:PDL BioPharma Announces Exchange to Retire 2.00% Convertible Senior Notes Due February 15, 2012 2PDL BioPharma Announces Exchange to Retire 2.00% Convertible Senior Notes Due February 15, 2012 3New Finding of Rise in H5N1 Virus (Avian Flu) Replikin Count 2Scrambling for climate change solutions 2
(Date:2/10/2015)... -- Alere Inc. (NYSE: ALR), a global leader in ... quarter ended December 31, 2014. Namal ... said, "We made substantial progress in the fourth ... in rapid diagnostics and delivering against our financial ... early January enabled us to substantially reduce our ...
(Date:2/5/2015)... DIEGO , Jan. 26, 2015   Epic Sciences ... of cancer, today announced that Murali Prahalad , Ph.D., ... Personalized Medicine World Conference (PMWC) 2015: Silicon Valley, which ... Mountain View, Calif. on January 26-28, 2015. ... "CTCs Come of Age as Biomarkers." Last year, Epic Sciences ...
(Date:2/5/2015)... , Jan. 28, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... upcoming RedChip Global Online CEO Conference on January 29 ... Gino Pereira , CEO of NXT-ID will present ... product, the Wocket smart wallet and its full suite ...
Breaking Biology News(10 mins):Alere Inc. Announces Fourth Quarter 2014 Results 2Alere Inc. Announces Fourth Quarter 2014 Results 3Alere Inc. Announces Fourth Quarter 2014 Results 4Alere Inc. Announces Fourth Quarter 2014 Results 5Alere Inc. Announces Fourth Quarter 2014 Results 6Alere Inc. Announces Fourth Quarter 2014 Results 7Alere Inc. Announces Fourth Quarter 2014 Results 8Alere Inc. Announces Fourth Quarter 2014 Results 9Alere Inc. Announces Fourth Quarter 2014 Results 10Alere Inc. Announces Fourth Quarter 2014 Results 11Alere Inc. Announces Fourth Quarter 2014 Results 12Alere Inc. Announces Fourth Quarter 2014 Results 13Alere Inc. Announces Fourth Quarter 2014 Results 14Alere Inc. Announces Fourth Quarter 2014 Results 15Alere Inc. Announces Fourth Quarter 2014 Results 16Alere Inc. Announces Fourth Quarter 2014 Results 17Alere Inc. Announces Fourth Quarter 2014 Results 18Alere Inc. Announces Fourth Quarter 2014 Results 19Alere Inc. Announces Fourth Quarter 2014 Results 20Alere Inc. Announces Fourth Quarter 2014 Results 21Alere Inc. Announces Fourth Quarter 2014 Results 22Alere Inc. Announces Fourth Quarter 2014 Results 23Alere Inc. Announces Fourth Quarter 2014 Results 24Alere Inc. Announces Fourth Quarter 2014 Results 25Alere Inc. Announces Fourth Quarter 2014 Results 26Alere Inc. Announces Fourth Quarter 2014 Results 27Alere Inc. Announces Fourth Quarter 2014 Results 28Alere Inc. Announces Fourth Quarter 2014 Results 29Alere Inc. Announces Fourth Quarter 2014 Results 30Alere Inc. Announces Fourth Quarter 2014 Results 31Alere Inc. Announces Fourth Quarter 2014 Results 32Alere Inc. Announces Fourth Quarter 2014 Results 33Alere Inc. Announces Fourth Quarter 2014 Results 34Alere Inc. Announces Fourth Quarter 2014 Results 35Alere Inc. Announces Fourth Quarter 2014 Results 36
... can examine single molecules in order to determine ... more accurately examine single cancer cells, has been ... UCLA's California Nanosystems Institute (CNSI), New York ... Instruments, a nanotechnology company. Their work appears in ...
... Wildlife Conservation Society's New York Aquarium received the ultimate ... African island nation of Madagascar was named after him. ... his career safeguarding Madagascar's little- known freshwater fishes, received ... American Museum of Natural History (AMNH), after they named ...
... with an overt reaction to toxins that cause oxidative ... health threats. , At the 233rd American Chemical Society ... Tech and the Edward Via Virginia College of Osteopathic ... biosensor prototype and correlations to brain tissue damage. ...
Cached Biology News:Bacterial response to oxidation studied as toxin barometer 2Bacterial response to oxidation studied as toxin barometer 3
... goat anti-rabbit IgG FITC is used ... immunofluorescent staining on tissues or culture ... generated in rabbits. It is highly ... as omitting the primary antibody, be ...
1000X solution used for inducing CopyControl™ based vectors to high copy numbers...
Request Info...
HAS1 (C-14)...
Biology Products: