Navigation Links
Engineered cells could usher in programmable cell therapies
Date:2/2/2011

Boston, MA - In work that could jumpstart the promising field of cell therapy, in which cells are transplanted into the body to treat a variety of diseases and tissue defects, researchers at Brigham and Women's Hospital (BWH) have engineered cells that could solve one of the key challenges associated with the procedure: control of the cells and their microenvironment following transplantation.

In the work, reported in the journal Biomaterials on January 26, the team reports creating tiny internal depots within human mesenchymal adult stem cells, which among other functions are key to the generation of several tissues. These depots can slowly release a variety of agents to influence the behavior of not only the cells containing the depots, but also those close to them and even much farther away. The team demonstrated this by prompting mesenchymal stem cells to differentiate into the cells that make bone.

"This work could allow programmable cell therapies where the cell or the agent is the therapeutic," says Jeffrey Karp, leader of the work and co-director of the Center for Regenerative Therapeutics (ReGen Rx) at BWH. "For example, depots containing specific agents could enhance cell survival or expression of a particular growth factor. Cells could also be used as a delivery vehicle to shuttle drugs to target tissues that may be useful to accelerate tissue regeneration, or to deliver chemotherapeutics to tumors while minimizing systemic side effects."

Toward Cell Therapy

"Ten to fifteen years from now, people will visit cell infusion centers to receive routine therapy for multiple diseases and tissue defects," predicts Karp, who also holds appointments through Harvard Medical School, Harvard Stem Cell Institute, and the Harvard-MIT Division of Health Sciences and Technology (HST). For example, a person who has had a heart attack could be infused with cells that could help stimulate regeneration of new heart
'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Interim Analysis of Data from e-HEALING Registry of OrbusNeichs Genous(TM) Bio-engineered R stent(TM) to be Presented at AHA Scientific Sessions 2008
2. Gene-engineered flies are pest solution
3. MIT, BU team combats antibiotic resistance with engineered viruses
4. OrbusNeichs Genous(TM) Bio-engineered R stent(TM) Demonstrates Impressive Results in Higher Risk Patients
5. Genetically engineered bacteria compute the route
6. First genetically engineered malaria vaccine to enter human trials
7. Pioneering research succeeds in producing industrially vital chemical through engineered bacteria
8. OrbusNeichs Genous(TM) Bio-engineered R stent(TM) is Feasible in Patients Requiring Undeferrable Non-Cardiac Surgery, International Journal of Cardiology Publication Reports
9. Engineered pea seeds protect against parasites
10. OrbusNeichs Genous(TM) Bio-Engineered R Stent(TM) is Safe in a Broad Population of Patients with Primary PCI for STEMI
11. Final 12 Month Clinical Data from 5,000 Patients in Worldwide e-HEALING Clinical Study Show Good Safety and Efficacy with Real World Use of OrbusNeichs Genous(TM) Bio-engineered R stent(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Engineered cells could usher in programmable cell therapies
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... 2011 Sequenom, Inc. (NASDAQ: SQNM ), a ... the Company,s participation at the Lazard Capital Markets 8th Annual ... November 15-16, 2011. Harry F. Hixson, Jr, Ph.D., ... EVP of Research and Development, will present on Tuesday, November ...
... of active metamaterial that incorporates semiconductor devices into conventional ... gain while retaining its negative refraction property, a first ... and experimental results show that the addition of the ... also maintained the negative index of this kind of ...
... 9, 2011 A new diagnostic kit ... been launched at the Veterinary Cancer Society,s annual conference ... ) in the UK, the announcement is a significant ... major benefit being that it is able to differentiate ...
Cached Biology Technology:Sequenom Announces Participation at the Lazard Capital Markets 8th Annual Healthcare Conference 2New metamaterial allows transmission gain while retaining negative refraction property 2New Kit Takes the Uncertainty Out of Lymphoma Diagnosis 2
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced ... America Perimeter Security Systems Market" report to their ... The North American perimeter security market is estimated ... to 2019. Although the U.S. market holds a larger ... is expected to grow at a higher CAGR of ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has ... in the APAC Region 2015-2019"  report to their ... in this market is advances in technology. With ... upgrade biometric solutions to the latest standard that ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... The increasing acidity of the world,s oceans and ... definitive proof that the atmospheric carbon dioxide that is ... environment, says world-renowned Antarctic marine biologist Jim McClintock, Ph.D., ... Department of Biology. "The oceans are a sink ...
... , PARIS , Feb. 4 ... network for Eurofins Scientific, a global leader in bio-analysis. , ... will securely connect 16 key Eurofins laboratories and research centers ... with the company,s global customer base.  Verizon will use MPLS ...
... COLLEGE STATION A joke among two Texas ... found Viagra can aid fetal development in female sheep. ... can serve as an excellent animal model for studying ... Viagra (sildenafil citrate), which is used to treat male ...
Cached Biology News:Oceans reveal further impacts of climate change, says UAB expert 2Oceans reveal further impacts of climate change, says UAB expert 3Verizon Business to Provide Global IP for Eurofins Scientific 2Verizon Business to Provide Global IP for Eurofins Scientific 3Study shows male erectile dysfunction drug enhances fetal growth in female sheep 2
Rabbit polyclonal to Peptide E ( Abpromise for all tested applications)....
Mouse monoclonal [6911] to E. coli K99 pilus ( Abpromise for all tested applications)....
...
...
Biology Products: