Navigation Links
Engineered anti-toxin antibodies improve efficacy
Date:1/9/2014

The effectiveness of toxin-neutralizing antibodies is considered to be mediated through the interaction of the variable region of the antibody and the toxin; however, recent studies suggest that the constant region (Fc) of antibodies also influence efficacy.

In this issue of the Journal of Clinical Investigation, Jeffrey Ravetch and colleagues at The Rockefeller University demonstrate that engineering the Fc domain of anti-toxin antibodies increases toxin neutralization activity through enhancing the interaction between toxin-targeting antibodies and the Fc receptor on immune cells. The authors found that mice expressing humanized FcR were better protected from anthrax toxin when given engineered anti-anthrax toxin antibodies.

This study suggests that engineering the Fc domains of antibodies can be used as a strategy to enhance antibody efficacy.


'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology technology :

1. The Engineered T-Cell Receptor in Fusion Proteins, Antibodies & Cells: Emerging Opportunities for the Biopharmaceutical Industry
2. Engineered T-Cell Receptor in Fusion Proteins, Antibodies & Cells Industry Trend: Worldwide Industry Latest Market Share, Investment Trends, Growth, Size, Strategy
3. The reins of Casimir: Engineered nanostructures could offer way to control quantum effect
4. Bioengineered Skin Substitutes to 2016. Products, Players, Markets and Growth Prospects
5. New bioengineered ears look and act like the real thing
6. Using 3-D printing and injectable molds, bioengineered ears look and act like the real thing
7. Will new methods that increase blood flow to bone implants improve viability of engineered bone tissue?
8. Highly efficient production of advanced biofuel by metabolically engineered microorganism
9. Preclinical data shows 100 percent prevention and treatment of influenza with engineered human antibody
10. Genetically engineered bacteria prevent mosquitoes from transmitting malaria
11. Microbes may be engineered to help trap excess CO2 underground
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... ... in biotechnology to help treat hormonal and stress related hair loss. With patent-pending ... the hearts of key opinion leaders in the medical and salon channels nationwide. ...
(Date:5/3/2016)... San Francisco, CA (PRWEB) , ... May 03, ... ... Morf Playbook™ enterprise talent development, skill-building and compliance training platform on ... Direct training course: Overview of Regulatory Requirements for Medical Devices. The course ...
(Date:5/3/2016)... ... May 03, 2016 , ... Leading CEOs from ... May 31st and June 1st at The Four Seasons Hotel Boston. , The ... life sciences, offering exclusive access to key decision makers who influence deal making ...
(Date:5/3/2016)... ... 2016 , ... Kerafast Inc., developers of an online ... globe, today announced the availability of a Zika virus antibody from Vanderbilt University. ... prevention measures for the Zika virus, the virus’s geographical distribution continues to widen ...
Breaking Biology Technology:
(Date:3/14/2016)... 2016 NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ... March 21 st .  The commercials will air on Bloomberg ... on the Street show. --> NXTD ) ("NXT-ID" ... commerce market, announces the airing of a new series of ...
(Date:3/10/2016)... --  Unisys Corporation (NYSE: UIS ) today announced ... testing its biometric identity solution at the Otay Mesa border ... identify certain non-U.S. citizens leaving the country. ... determine the efficiency and accuracy of using biometric technologies in ... until May 2016. --> the United States ...
(Date:3/3/2016)... MONTEREY, Calif. , March 3, 2016  FlexTech, ... in the categories of Innovation, Research & Development, Leadership ... Industry Leadership. This is the 9 th year ... select group of companies and individuals from past ... nominations based on a pre-described set of criteria, by ...
Breaking Biology News(10 mins):