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Encouraging HIV/AIDS Vaccine Trial Results Support GeoVax Labs, Inc. Strategy
Date:9/24/2009

accine - preventative and therapeutic - we continue to make progress," stated Dr. McNally. "The preventative version of the vaccine has advanced to a Phase 2a human clinical trial, which was initiated in February 2009 by the HIV Vaccine Trials Network (HVTN) and continues to have steadily increasing enrollment. On the therapeutic vaccine, we continue to plan out the details of a Phase 1 human clinical trial and expect to begin this trial, assuming U.S. Food and Drug Administration (FDA) concurrence, in the first quarter of 2010."

The Technology

GeoVax's unique two component vaccine, a recombinant DNA and a recombinant modified vaccinia Ankara (MVA), is designed to stimulate both anti-HIV T cell and anti-HIV antibody immune responses. GeoVax's DNA and MVA vaccines are used in a prime-boost protocol in which priming is done with the DNA and boosting with the MVA. GeoVax is also investigating a potentially simpler regimen in which MVA is used for both priming and boosting. Both the DNA and MVA express the three major proteins of the AIDS virus: Gag, Pol, and Env, and produce non-infectious virus-like-particles. These particles contain proteins that mimic more than half of the components of the AIDS virus, but cannot cause AIDS. This multi-protein approach is designed to elicit a broad multi-target protective T cell response. The Env protein is designed to elicit a protective antibody response against the natural form of the virus envelope glycoprotein as well as protective T cells.

"One of the strong features of our vaccines is their stability during manufacture," said Dr. Robinson. "During development, we and our collaborators at the National Institutes of Health persevered to construct vaccines that showed solid stability under commercial manufacturing conditions. We did not advance a vaccine until we had demonstrated stability. We have available inventory and can readily contract manufacture additional p
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SOURCE GeoVax Labs, Inc.
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