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Enbrel and Humira Remain the Mainstay for First-Line Biologic Rheumatoid Arthritis Treatment
Date:9/19/2013

EXTON, Pa., Sept. 19, 2013 /PRNewswire/ -- BioTrends Research Group, one of the world's leading research and advisory firms for specialized biopharmaceutical issues, finds that the vast majority of patients treated with Amgen's Enbrel and AbbVie's Humira—significantly more patients than those treated with any other nontraditional disease-modifying antirheumatic drug—were biologic-naive and, therefore, taking these agents as their first-line biologic treatment. Although Pfizer's Xeljanz has been on the market for only about six months at the time this study was fielded, nearly 60 percent of rheumatoid arthritis (RA) patients currently treated with Xeljanz were biologic-naive prior to initiation, which is in-line with its FDA-approved label.  Xeljanz-treated patients who were previously treated with another agent were most commonly switched from Enbrel, Humira and Bristol-Myers Squibb's Orencia IV.

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The ChartTrends®: Rheumatoid Arthritis (US) report also finds that, according to rheumatologists managing their care, the majority of Xeljanz-treated RA patients in the audit are showing good to excellent pain relief, functional status and quality of life. Also, 81 percent of Xeljanz-treated RA patients in the audit have experienced partial or complete remission since beginning treatment. 

"In addition to the positive response that physicians are reporting, nearly three-quarters of Xeljanz-treated patients are showing no signs of progression of structural damage," said BioTrends Research Group Associate Director Lynn Price. "This is an important issue for Pfizer as they are seeking expansion of the Xeljanz RA label to include inhibition of
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SOURCE BioTrends Research Group
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