Navigation Links
Emerging Lymphoma and Myeloma Treatments Focus on Improving Individual Patient Response
Date:12/11/2011

to be highly effective in the treatment of blood cancers like MM.

The exact mechanisms and targets through which these therapies work to enhance immune response or kill cancer cells has been largely unknown; therefore, it has been challenging to understand which patients to treat and to distinguish the positive properties of these drugs from the side effects. After recent research identified a specific protein known as cereblon as a primary mediator of the birth defects caused by thalidomide, a hypothesis emerged that cereblon may also be responsible for the anti-tumor properties of IMiDs.

To test whether the presence of cereblon in myeloma cells might be partly responsible for resistance or response to MM treatment, and thus may potentially serve as a target for therapeutic intervention, researchers examined MM cell lines resistant to IMiDs and found that expression of the cereblon gene was either low or entirely absent, suggesting a possible link between resistance to IMiDs and presence of the protein.

The team then lowered the level of cereblon expression in five human-derived MM cell lines, which caused the cell lines to become almost completely resistant to lenalidomide (compared with control cell lines) yet remain sensitive to other myeloma therapies such as melphalan, dexamethasone, and bortezomib. The investigators then examined the DNA of 10 MM patients who were resistant to IMiD therapy and found low levels of cereblon expression in eight of those 10 patients, further emphasizing that cereblon expression appears necessary for IMiDs to work properly. Interestingly, some resistant patients had normal cereblon levels, suggesting that while cereblon may be an absolute requirement for response, there are likely other mechanisms present that play a role in drug resistance.

"These findings help us understand which patients may be more or less likely to respond to therapy and will allow us to focus on other ways we can target cereblo
'/>"/>

SOURCE American Society of Hematology
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related biology technology :

1. Established and Emerging Biotech Clusters
2. PAREXEL International to Present at Robert Baird Healthcare Conference and William Blair Emerging Growth Stock Conference
3. Tumor Marker Diagnostic Technologies: Assessment of Current and Emerging Technologies, And Their Potential Market Applications
4. GRAPHENE-CA appointed an EU Future Emerging Technology flagship pilot
5. Reportlinker Adds Top & Emerging Bio-Fuel Markets by Technology, Feedstocks, Regulations, Pricing & Commercialization Trends & Forecasts (2011 - 2016)
6. Reportlinker Adds The 2011 Blood Banking Market: US, Europe, Japan - Emerging Opportunities and Business Expansion Strategies for Suppliers
7. Zimmer Helps Physicians and Hospitals Negotiate Emerging Health Care Business Challenges Through New Consulting Programs
8. Elixir Bio-Tech Inc. Elected One of Top 50 Emerging Companies by 100 Venture Capital Funds & Angel Investors
9. Reportlinker Adds Future US In Vitro Diagnostics Market: Strategic Implications of Emerging Reimbursement, Technological and Market Trends Through 2018
10. Reportlinker Adds The 2011 Coagulation Testing Market: US, Europe, Japan Emerging Business Opportunities and Market Expansion Strategies for Suppliers
11. Reportlinker Adds Emerging Opportunities in Biosimilar and Biobetter Drugs Markets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... , Sept. 17, 2014 /PRNewswire/ - SQI Diagnostics ... that develops and commercializes proprietary technologies and products for ... have been approved for trading in the ... Trading is expected to commence on September 17, 2014 ... will continue to trade on the TSX Venture Exchange ...
(Date:9/17/2014)... Escape Alert, LLC . filed international patents for an ... their pet has escaped and enable them to track their pet’s ... body. This is the first implantable microchip with GPS. , ... many years, they are passive until read by scanners, do not ... or alert the owner that the pet has escaped. Escape ...
(Date:9/16/2014)... “Nature has developed, very cleverly, some lessons ... in optical design,” said Joseph Shaw, director of the ... explore surfaces and structures at the nanoscale, we’ll discover ... San Diego in August during a conference called “ ... by Shaw and Rongguang Liang of the University of ...
(Date:9/16/2014)... From cell phones to cars and flashlights, ... Scientists and technology companies constantly are seeking ways ... the first time using a water-based solution, researchers ... long-lasting and more efficient nuclear battery that could ... reliable energy source in automobiles and also in ...
Breaking Biology Technology:SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 3Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 2Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 3Nature’s designs inspire research into new light-based technologies 2Nature’s designs inspire research into new light-based technologies 3Nature’s designs inspire research into new light-based technologies 4Nature’s designs inspire research into new light-based technologies 5
... The manufacturer of the nation,s first organic ... tests that refute recent allegations its products may ... (Photo:  http://photos.prnewswire.com/prnh/20120305/CL64361 ) The ... formula products manufactured by Nature,s One, Inc. fall ...
... and tsunami hit Japan on March 11, 2011, an ... disaster planning and crisis management for the accident at ... now in the Bulletin of the Atomic Scientists ... unprepared for the cascading nuclear disaster, following a tsunami ...
... -- FirstMark, the diagnostic division of GenWay Biotech, ... that was held today on March 1, 2012. The ... and research. The main focus of the Board will ... validation of FirstMark,s new cardiovascular test PREvent. PREvent is ...
Cached Biology Technology:Arsenic Testing Proves Organic Baby Formula Safe 2Fukushima 1 year on: Poor planning hampered Fukushima response 2Fukushima 1 year on: Poor planning hampered Fukushima response 3Inaugural Meeting of the FirstMark Scientific Board of Advisors 2Inaugural Meeting of the FirstMark Scientific Board of Advisors 3
(Date:9/17/2014)... have obtained the first partial genome sequence of an ... at the site of the Montsoriu Castle in Girona, ... closely related to today,s Iberian pig. Researchers also discard ... Iberian pigs. , The study, published in Heredity ... species, and particularly on that of the Iberian breed, ...
(Date:9/17/2014)... researchers working on a Carnegie expedition in Australia,s Great ... plummeted 40% since the mid-1970s. The scientists suggest that ... this perilous slowdown. , In a quest for ... team compared current measurements of the growth rate of ... measurements taken more than 30 years ago. Their work ...
(Date:9/17/2014)... learned a great deal about complex social behavior by ... something to teach too. , With their unusually large ... parrots live in a complex social environment---not merely in ... or ants, but in a dynamic setting of alliances ... intelligent mammals: dolphins, whales, primates, and social carnivores, like ...
Breaking Biology News(10 mins):Iberian pig genome remains unchanged after 5 centuries 2Coral growth rate plummets in 30-year comparison 2Being social: Learning from the behavior of birds 2
... system hates strangers. When its security patrol spots a ... problem when people with type 1 diabetes undergo human ... pancreas produce robust amounts of insulin for the recipient ... immune system tries to kill the new hard-working islets. ...
... the time of birth, mouse ovaries are essentially a ... are forming. This key time in ovarian development establishes ... of a cohort of follicles. If follicles fail to ... also essential for follicular development. Several factors key to ...
... of star-forming clouds to the flow of the molten Earth,s ... to the coursing blood in your veins, from the aerodynamics ... ocean, many of nature,s most fascinating phenomena are forms of ... American Physical Society,s Division of Fluid Dynamics, which takes place ...
Cached Biology News:New technique eliminates toxic drugs in islet transplant in diabetic mice 2December 2008 highlights from Biology of Reproduction 2The physics of star-forming clouds and the urban environment 2The physics of star-forming clouds and the urban environment 3The physics of star-forming clouds and the urban environment 4The physics of star-forming clouds and the urban environment 5The physics of star-forming clouds and the urban environment 6
MOUSE ANTI GUINEA PIG T-CELLS (PAN):FITC Immunogen: Guinea pig peritoneal T-cells...
Prepared in 0.85% saline....
RABBIT ANTI HUMAN CYTOCHROME P450 1A1/2 Immunogen: Purified human CYP1A2 expressed in E.Coli ...
SHEEP ANTI HUMAN ESTRONE...
Biology Products: