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Elusys Releases New Data On Anthrax Anti-Toxin Administered Via Intramuscular Injection From Three Recent Animal Studies
Date:7/31/2013

PINE BROOK, N.J., July 31, 2013 /PRNewswire/ -- Elusys Therapeutics, Inc. (Elusys), a biopharmaceutical company developing antibody therapies to treat infectious disease, today released data from three recently completed studies of ETI-204 (Anthim) administered by intramuscular (IM) injection. ETI-204, an anthrax anti-toxin, is an investigational agent in late stage development for the treatment of inhalational anthrax infection. 

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Two of the studies assessed IM administration of ETI-204 following challenge with aerosolized B. anthracis spores (either before or after the development of symptoms of anthrax). A third study examined the potential protective effect of administering ETI-204 at various times prior to challenge with B. anthracis. All three studies were conducted in cynomolgus monkeys.

"These three recent studies demonstrate promising results of ETI-204 when given to anthrax exposed animals via intramuscular administration," said Elizabeth Posillico, PhD, President and Chief Executive Officer of Elusys. "ETI-204 could offer an important complement to the current anthrax countermeasures."

The first study was a randomized, blinded, seven-arm, placebo-controlled, post-challenge, timed-treatment study. Animals were exposed to Bacillus anthracis spores and treated with a single dose of ETI-204 (8 or 16 mg/kg IM) at 18, 24 or 36 hours after challenge with aerosolized B. anthracis spores. The primary endpoint was survival at 28 days after challenge. Animals treated at 18 and 24 hours post-challenge demonstrated statistically significantly higher survival rates -- 100% (6/6) and 83% (5/6), respectively -- than control, regardless of ETI-204 dose. Animals treated with 8 mg/kg at 36 hours post-challenge succum
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SOURCE Elusys Therapeutics, Inc.
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