Navigation Links
Ebola antibody treatment, produced in plants, protects monkeys from lethal disease
Date:10/25/2012

ffective medical countermeasure, according to the authors. Initially developed as a monoclonal antibody cocktail in the mouse model, MB-003 was successfully humanized and then produced in the tobacco plant-based production system.

"We were pleased to see how well the humanized mAbs of MB-003 performed," said Larry Zeitlin, Ph.D., president of Mapp Biopharmaceutical and senior author on the study. "We also were pleasantly surprised by the superiority of the plant-derived mAbs compared to the same mAbs produced in traditional mammalian cell culture."

Further improvement in antibody efficacy was developed at Kentucky BioProcessing (KBP). Using a fully automated production system that operates in accordance with good manufacturing practices (GMP), antibody is produced in a tobacco plant system. This new development process significantly decreases the amount of time required for production, increases the quantity of antibody produced, and slashes the cost of manufacturing, according to Barry Bratcher, chief operating officer of KBP and co-author on the PNAS study.

"Our GMP facility can generate a new antibody lot in two weeks to rapidly address new threats and new outbreaks," said Bratcher.

Olinger said efforts are underway to advance MB-003 to clinical safety testing as his team at USAMRIID continues to determine the true therapeutic capability of the cocktail.


'/>"/>

Contact: Caree Vander Linden
caree.vanderlinden@us.army.mil
US Army Medical Research Institute of Infectious Diseases
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Preclinical data shows 100 percent prevention and treatment of influenza with engineered human antibody
2. Oncobiologics, Inc. Announces a Collaboration Agreement with XOMA Corporation to Utilize XOMAs Fully Human Antibody Libraries for Their Discovery Platform
3. Sanofi and Regeneron Launch Comprehensive Phase 3 Clinical Program With LDL Cholesterol-Lowering PCSK9 Antibody
4. RayBiotech, Inc. and the University of Oslo Enter into Antibody Array Services Collaboration
5. Sinovac to Present at 55th Annual BioPharma China Convention 2012 - Vaccine & Antibody Focus
6. Acute Lymphocytic Leukemia: Impressive Results With the Monoclonal Antibody Blinatumomab in Patients With Refractory Disease
7. Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet
8. AnaptysBio Announces Antibody Discovery Partnership With Gilead Sciences
9. Quest Diagnostics STRATIFY JCV™ First FDA Market Authorized Antibody-based Blood Test to Help Stratify PML Risk in Multiple Sclerosis Patients
10. AnaptysBio Announces New Strategic Antibody Discovery
11. Epitomics, Inc. and University of California, Davis, Complete Star Program for High-Throughput Measurement of Antibody-Antigen Interactions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2015)... April 23, 2015 Proove ... Personalized Medicine, is excited to announce the launch ... . This profile assesses 62 genetic variations to ... information for commonly prescribed non-opioid pain medications, namely ... Neurontin), alprazolam (brand name Xanax) and acetaminophen (brand ...
(Date:4/23/2015)... ReliantHeart's HeartAssist5® Ventricular Assist Device (VAD) precisely measure ... in real time, and this data is uploaded to ... Machine to Machine (M2M) communications for the Internet of ... can be monitored by a patient’s clinician 24/7, ... a minimum threshold, the patient can be notified immediately. ...
(Date:4/22/2015)... /PRNewswire/ - BioAmber Inc. (NYSE and EURONEXT Paris:BIOA) today announced that it will ... Thursday, May 7, 2015 after the close of the ... call for 4.30 pm ET (1.30 pm PT) to ... the conference call will be webcast over the internet ... news media and the general public. To access the ...
(Date:4/22/2015)... Va. , April 22, 2015 ... TowerView Health was the winner of the 9th annual ... Fifteen startup companies were selected to deliver live ... industry leaders, as part of HIMSS15 held last week ... more than 43,000 health IT professionals and 1,200 exhibiting ...
Breaking Biology Technology:Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 2Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 3BioAmber Announces Webcast of Fiscal First Quarter 2015 Financial Results 2TowerView Health Named Venture+ Forum Pitch Competition Winner At HIMSS15 2TowerView Health Named Venture+ Forum Pitch Competition Winner At HIMSS15 3
... Source: Fiserv Imagesoft BROOKFIELD, Wis. Fiserv ... firm Fiserv, announced on Thursday that it has completed ... are geared specifically toward improving the security of image ... scanned image of an original check. , ,The new ...
... mission to Japan is building interest in possible Wisconsin ... abroad in a conference call Monday morning. , ,In ... Wisconsin representatives, Doyle has been speaking at biotechnology meetings ... much of today telling people about the value of ...
... of software. The first is that any mildly successful software ... an operating system. Thats a topic for another column. The ... piece of software that its designers never imagined. , ,EBays ... eBay bought Half.com intending to shut it down and move ...
Cached Biology Technology:Doyle builds bridges and hopes for deals in Japan 2Doyle builds bridges and hopes for deals in Japan 3Byron's laws of software 2Byron's laws of software 3
(Date:4/2/2015)... , April 2, 2015 ... DERMALOG by far outperforms the strongest competitors, showing ... high accuracy, the system is capable of a ... speed proves up to be ten times faster ... its runner-up performance.      (Photo: ...
(Date:4/1/2015)... OXFORD, Conn. , Apr. 1, 2015  NXT-ID, ... a biometric authentication company focused on the growing mobile ... number of Wocket smart wallets is underway to early ... early access group includes usage at retail outlets including ... CVS Pharmacy. Users report Wocket was accepted at all ...
(Date:3/30/2015)... , Mar. 26, 2015 Research and Markets ... of the "Global Gesture Recognition Market in Automotive ... The analysts forecast the Global Gesture Recognition market in ... over the period 2013-2018. Gesture recognition is ... to different gestures of an individual. Gesture recognition technology ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2
... of Velociraptor rewrites evolutionary charts , The recent ... that dromaeosaurs, a group of carnivorous theropods that ... originated much earlier than previously thought. Rather than ... traced back to the Jurassic, possibly as far ...
... a pheromone emitted by older male elephants in musth influences ... surrounding elephants behave, a new study has found. , ... University of Auckland in New Zealand say the release of ... frontalin, depends on whether the male elephant is mature enough ...
... immune system to absorb and digest pathogenic intruders. Some ... multiply within the macrophages. Cell biologists at the University ... recently publication in the journal 'Traffic' (Vol. 6, No. ... pathogens escape the 'stomach' of the macrophages which might ...
Cached Biology News:Newly discovered birdlike dinosaur is oldest raptor ever found in South America 2Newly discovered birdlike dinosaur is oldest raptor ever found in South America 3Newly discovered birdlike dinosaur is oldest raptor ever found in South America 4Male elephants woo females with precise chemistry 2Male elephants woo females with precise chemistry 3Dangerous tricksters: Some bacterie use immune cells to reproduce 2Dangerous tricksters: Some bacterie use immune cells to reproduce 3
One-step, microplate or cuvet, colorimetric, detection range 0.04% to 4%. Procedure: 30 min....
One-step, microplate or cuvet, colorimetric, linear detection range 6 mg/dL to 100mg/dL. Procedure: 15 min....
...
Homo sapiens 4-aminobutyrate aminotransferase Antigen: Recombinant Protein...
Biology Products: