Navigation Links
Ebola antibody treatment, produced in plants, protects monkeys from lethal disease
Date:10/25/2012

A new Ebola virus study resulting from a widespread scientific collaboration has shown promising preliminary results, preventing disease in infected nonhuman primates using monoclonal antibodies.

In this week's online edition of the Proceedings of the National Academy of Sciences (PNAS), the research team describes a proof-of-concept for using a "cocktail" of monoclonal antibodies, or mAbs, to prevent lethal disease in rhesus macaques. When administered one hour after infection, all animals survived. Two-thirds of the animals were protected even when the treatment, known as MB-003, was administered 48 hours after infection.

Ebola virus, which causes hemorrhagic fever with human case fatality rates as high as 90 percent, has been responsible for numerous deaths in central Africa over the past several months. In addition to being a global health concern, the virus also is considered a potential biological threat agent. Currently there are no available vaccines or treatments approved for use in humans.

The work is the culmination of more than a decade of effort between government and industry partners. According to lead investigator Gene Olinger, Ph.D., a virologist at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), this consortium of investigators has taken very distinct technologies and combined them to develop a cutting-edge medical countermeasure against a lethal viral disease.

"It is rare that an antiviral compound prevents Ebola virus infection with limited to no morbidity in treated animals at any point of treatment following infection by this lethal virus," said Olinger. "Until recently, attempts to utilize antibodies to provide protection against Ebola virus have been met with failure. The level of protection against disease that we saw with MB-003 was impressive."

In addition, the production method used in this study offers the potential to make an economical and e
'/>"/>

Contact: Caree Vander Linden
caree.vanderlinden@us.army.mil
US Army Medical Research Institute of Infectious Diseases
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Preclinical data shows 100 percent prevention and treatment of influenza with engineered human antibody
2. Oncobiologics, Inc. Announces a Collaboration Agreement with XOMA Corporation to Utilize XOMAs Fully Human Antibody Libraries for Their Discovery Platform
3. Sanofi and Regeneron Launch Comprehensive Phase 3 Clinical Program With LDL Cholesterol-Lowering PCSK9 Antibody
4. RayBiotech, Inc. and the University of Oslo Enter into Antibody Array Services Collaboration
5. Sinovac to Present at 55th Annual BioPharma China Convention 2012 - Vaccine & Antibody Focus
6. Acute Lymphocytic Leukemia: Impressive Results With the Monoclonal Antibody Blinatumomab in Patients With Refractory Disease
7. Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet
8. AnaptysBio Announces Antibody Discovery Partnership With Gilead Sciences
9. Quest Diagnostics STRATIFY JCV™ First FDA Market Authorized Antibody-based Blood Test to Help Stratify PML Risk in Multiple Sclerosis Patients
10. AnaptysBio Announces New Strategic Antibody Discovery
11. Epitomics, Inc. and University of California, Davis, Complete Star Program for High-Throughput Measurement of Antibody-Antigen Interactions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Md. (PRWEB) September 17, 2014 ... Comprehensive Two-Dimensional Liquid Chromatograph (2D-LC), which offers ... complex sample matrices. The system provides a ... sample analytes, which is beneficial to scientists ... extracts, and natural products. , Comprehensive 2D-LC ...
(Date:9/17/2014)... PA & Rockville, MD (PRWEB) September 17, 2014 ... won a Small Business Innovation Research (SBIR) grant to ... immunotherapy. The award will provide ITI with approximately $255,000 ... Tree nuts, a leading cause of food allergy, affect ... cause of anaphylaxis behind peanut allergy. Tree nut exposure ...
(Date:9/17/2014)... /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: SQD) (OTCQX: SQIDF), ... technologies and products for advanced microarray diagnostics, today announced ... in the United States on ... on September 17, 2014 on the OTCQX under the ... the TSX Venture Exchange under its existing symbol SQD. ...
(Date:9/17/2014)... Escape Alert, LLC . filed international patents ... alert owners if their pet has escaped and enable them to ... in the pet’s body. This is the first implantable microchip ... been around for many years, they are passive until read by ... a pet’s location or alert the owner that the pet has ...
Breaking Biology Technology:Shimadzu’s New Nexera-e Two Dimensional Comprehensive Liquid Chromatograph Empowers Laboratories to Separate Even the Most Complex Mixtures 2Immunomic Therapeutics Awarded SBIR Grant to Develop Multi-Nut Allergy Immunotherapy 2Immunomic Therapeutics Awarded SBIR Grant to Develop Multi-Nut Allergy Immunotherapy 3SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 3Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 2Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 3
... DENVER, Nov. 8, 2011 Quest Diagnostics joined the ... participate in the American Cancer Society,s historic Cancer Prevention ... this national, longitudinal study is between November 8 and ... lifestyle, environmental and genetic factors that influence cancer risk ...
... VIENNA, November 8, 2011 Santo VC ... AFFiRiS AG   effective immediately and has also secured an ... same time, the German MIG fund increased its existing investment ... fund. As a result, AFFiRiS now has an additional EUR ...
... Biotech, Inc. (a suburban Philadelphia-based Company) announced today, at ... brand name of its flagship product to "RENADYL™." Formerly ... probiotic formulation helps maintain healthy kidney function. At a ... and health benefits of probiotics, Kibow has opted for ...
Cached Biology Technology:Quest Diagnostics Encourages Denver Area Residents to Enroll in Historic American Cancer Society Prevention Study November 8th - 19th 2Quest Diagnostics Encourages Denver Area Residents to Enroll in Historic American Cancer Society Prevention Study November 8th - 19th 3AFFiRiS AG: Capital Increase: AFFiRiS Brings Santo VC and MIG 11 on Board 2AFFiRiS AG: Capital Increase: AFFiRiS Brings Santo VC and MIG 11 on Board 3AFFiRiS AG: Capital Increase: AFFiRiS Brings Santo VC and MIG 11 on Board 4Kibow Changes Name of Flagship Kidney Function Support Product to 'RENADYL™' 2
(Date:9/16/2014)... on September 13, 2014. The fire is human-caused and ... 2,300 acres in size and is mostly being fueled ... calm Monday night due to higher humidity. Yesterday ... beginning to construct a fireline on the West and North ... on the fire: , 7 20-person Crews, 4 Hot Shot ...
(Date:9/16/2014)... of rock hit the Yukatan peninsula near the site of ... teratons of TNT. It left a crater more than 150 ... volcanism are widely accepted to have wiped out the dinosaurs ... what happened to the plants on which the dinosaurs fed? ... of Arizona reveals that the meteorite impact that spelled doom ...
(Date:9/16/2014)... votes for independence later this week, its Government could ... that fracking is necessary, research has revealed. , The ... public perception of shale gas extraction in the UK ... north of the border are the least supportive of ... in the University,s School of Geography, said: "The clear ...
Breaking Biology News(10 mins):Meteorite that doomed the dinosaurs helped the forests bloom 2Meteorite that doomed the dinosaurs helped the forests bloom 3Scottish people most sceptical on fracking, survey shows 2Scottish people most sceptical on fracking, survey shows 3
... in their own interests and do not cooperate ... severity of infection. The selfish behaviour ... treat antibiotic-resistant infections, according to research being presented ... today. Bacteria work together by using a ...
... TORONTO, ON - Widespread reports of a decline in the ... and speculation that pollination is also likely on the decline. ... long-term evidence of a downward trend in pollination, while also ... numbers may have declined at our research site, but we ...
... San Diego have discovered that a gene critical for programmed ... stem cells, a finding that could help to improve the ... chemotherapy or radiation therapy that kills cancer cells by inducing ... side effects for human cancer patients is the depletion of ...
Cached Biology News:Backstabbing bacteria: A new treatment for infection? 2Biologists find way to reduce stem cell loss during cancer treatment 2
... Cell Lines ,High Quality, Functionally-Validated, Ion Channel ... known for having a critical role in ... a key function in pain, CNS and ... have been investigated in therapeutic areas, such ...
... PrecisION Ion Channel Cell Lines ,High ... ,Ion channels are well known for having ... function and consequently have a key function ... that modulate ion channels have been investigated ...
... PrecisION Ion Channel Cell Lines ,High ... ,Ion channels are well known for having ... function and consequently have a key function ... that modulate ion channels have been investigated ...
Mouse polyclonal antibody raised against a partial recombinant CD320. NCBI Entrez Gene ID = 51293...
Biology Products: