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Easy assembly of electronic biological chips
Date:1/15/2009

crofluidic channels to control where each nanowire type goes," says Mayer. "We can run the solution over the whole chip and its wires will only attach where they are supposed to attach. This is important for scale-up."

The researchers then move the electric field and position the next tagged nanowires. In this proof-of-concept experiment, the different tagged wires were placed in rows, but the researchers say that they could be placed in a variety of configurations.

After all the wires are in place, they can be made into a variety of devices including resonators or field effect transistors that can be used to detect nucleic acid targets.

While the researchers have not yet connected each individual device to the underlying circuitry, they did test their chip to ensure that the wires assembled in the proper locations. They immersed the chip in a solution containing DNA sequences complementary to the three virus-specific sequences on the nanowires. Because they tagged the complimentary DNA with three differently colored fluorescent dyes, the attached DNA showed that the wires were in the proper places.

The researchers believe that their assembly method is extremely flexible, capable of placing a variety of conducting and non-conducting wires with a wide array of coatings.

"The eventual idea would be to extend the method to more nanowire types, such as different DNA sequences or even proteins, and move from fluorescence to real-time electrical detection on the chip," says Keating.


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Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State
Source:Eurekalert  

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