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ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems
Date:9/3/2008

ative metabolism, to cardiovascular and neurodegenerative-disease mechanisms, to signal transduction. While ESA's Synthesis cells reduce the time and complexity of synthesizing significant quantities of difficult-to-obtain metabolites from a variety of parent compounds; with traditional systems it can take six months to a year to generate enough material for a typical drug-metabolite study. In these areas and many others, ESA is making a substantial contribution to advance the field of metabolomics."

"The Frost & Sullivan Innovation Award comes as ESA is completing metabolomics work made possible by a grant from the National Institutes of Health Roadmap for Medical Research initiative (awarded in 2005)," said ESA's Dr. Acworth. "Our studies show that EC-Array and MS are complementary in nature, and the combined use of two sensitive and selective detection techniques can provide greater coverage of the metabolome than either technique alone. This can be very useful in new FDA-mandated drug safety testing to evaluate active/toxic human drug metabolites. Studies have shown that drugs can metabolize differently in humans than in other animals, resulting in potentially toxic levels of drug metabolites that can't be identified by animal studies alone. Electrochemical detection in line with mass spectrometry streamlines the metabolite analysis, synthesis, and evaluation process. In order to determine the clinically relevant metabolite levels in human plasma/tissues, metabolites can be synthesized and identified and then matched to what's seen in relevant animal studies. When the appropriate metabolites are identified, scale-up can be done for clinical trials to evaluate metabolite toxicity in humans."

Dr. Acworth continued, "We are honored to be recognized by Frost & Sullivan, and continue to be inspired by our customers. Many of the innovative applications for our technology have their origins in customer labs. Their breakthrough research opens up new invest
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SOURCE Magellan Biosciences
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