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ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials
Date:5/21/2013

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(5) Silbernagel, G et al. "CHOLESTEROL ABSORPTION PREDICTS THE EFFECTIVENESS OF ATORVASTATIN FOR PREVENTING CARDIOVASCULARDISEASE IN HEMODIALYSIS PATIENTS"

High cholesterol absorption efficiency in a patient was predictive of the poor effectiveness of atorvastatin therapy in terms of cardiovascular endpoints. Consequently, measurement of cholesterol absorption might identify those dialysis patients who would benefit from statin therapy.

(6) De Zeeuw, D et al. "THE SELECTIVE TYPE A ENDOTHELIN ANTAGONIST ATRASENTAN REDUCES RESIDUAL ALBUMINURIA IN PATIENTS WITH TYPE 2 DIABETES AND NEPHROPATHY"

A greater than 30% reduction in albuminuria was recorded in more than half the patients treated with atrasentan. In addition, there were significant reductions in LDL cholesterol as well as triglyceride levels in the active treatment groups. Atrasentan might therefore be a highly promising new therapy, in addition to RAAS blockade, for reducing albuminuria in diabetic patients.

(7) Cannata-Andia, JB et al. "THE USE OF PTH-LOWERING DRUGS IS ASSOCIATED WITH IMPROVED SURVIVAL IN HEMODIALYSIS PATIENTS: RESULTS FROM COSMOS"

As part of the COSMOS study, a 3-year European multicentre observational study conducted in 6273 HD patients, a prospective evaluation of the effect of PTH-lowering products on patients´ outcome was performed: Patients benefited significantly from all PTH-lowering treatments.

(8) Floege, J et al. "SAFETY AND EFFICACY OF PA21, A NOVEL IRON-BASED PHOSPHATE BINDER, IN PATIENTS WITH ESRD AND HYPERPHOSPHATEMIA: LONG-TERM RESULTS"

This is a 28-week extension of a comparative study already presented in 2012 which had demonstrated similar efficacy for the two phosphate binders. In the study extension the phosphate-lowering effect of both treatments remained constant. In addition, it was shown that the adverse effects in the PA21 group diminished over time (in terms of its adverse effect profile, PA21 was in
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SOURCE European Renal Association - European Dialysis and Transplant Association (ERA-EDTA)
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