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EORTC, BIG, and Agendia Announce Completion of Patient Recruitment for International MINDACT Study
Date:10/18/2011

of these drugs by improving treatment success rates," said Bernhard Sixt, CEO and co-founder of Agendia. "In addition, MINDACT will likely generate new specific companion diagnostics that can be added to MammaPrint® in Agendia's Symphony™ decision support system to further improve its clinical value."

According to the MINDACT principal investigators (Drs Emiel Rutgers, Martine Piccart, and Fatima Cardoso), "The enthusiasm and commitment of all the many people involved in MINDACT - surgeons, pathologists, medical oncologists, research nurses and patients - have proven the doubters wrong.  We are delighted to be able to show that it is possible to conduct such a complex international trial in a short period of time, and are convinced that MINDACT, with its rich collection of biological and clinical data, will nurture breast cancer research for years to come."  

MINDACT is the largest European randomized prospective trial evaluating the clinical value of a genomic profile for risk assessment and adjuvant chemotherapy prescription for breast cancer. The trial's complex logistics, including real-time collection of frozen tumor tissue, were proven feasible in a multinational, multicenter setting. Based upon patients' risk of recurrence classification by MammaPrint® and clinicopathological criteria, they are offered adjuvant chemotherapy (a non-mandatory randomisation between commonly administered anthracycline-based regimens and the study combination of docetaxel plus capecitabine). Endocrine treatment is also offered to the patients whose tumors express hormone receptors (a non-mandatory randomisation between letrozole and tamoxifen followed by letrozole). The entire genomic profile of each patient's tumor is also being analyzed, and this could allow research groups involved in the consortium to find new, specific companion diagnostics for the drugs administered in the trial. Agendia holds exclusive commercial righ
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SOURCE Agendia B.V.
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Related biology technology :

1. Agendia Successfully Completes Bi-Annual FDA Inspection
2. Agendia Presents Broad Array of Predictive and Prognostic Studies on Breast and Colorectal Cancers at ASCO 2010 Annual Meeting
3. Agendia Receives New York State Laboratory Permit and Laboratory Accreditation by College of American Pathologists
4. Medicare Administrator Establishes Reimbursement Coding Policy for Agendias Breast Cancer Recurrence Test MammaPrint(R)
5. Agendia Raises US $23 Million in Series E Financing
6. Agendia Supports Genentechs Citizens Petition Urging FDA to Hold In-Vitro Diagnostic Tests to One Set of Scientific and Regulatory Standards
7. Agendia Opens CLIA-Registered U.S. Genomics Laboratory
8. Agendia to Present Multiple Predictive and Prognostic Studies on Breast and Colorectal Cancers at ASCO Annual Meeting
9. Agendia to Present at BioCenturys Future Leaders in the Biotech Industry Conference
10. Agendia Presents Data Supporting MammaPrints Predictive and Prognostic Power at 2009 St. Gallen Breast Cancer Conference
11. Agendia Appoints Seasoned Diagnostics Executive Albert A. Luderer to Supervisory Board
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