Navigation Links
Dynavax Reports Progress in Lupus Program With Inhibitor of TLR7 and TLR9
Date:11/26/2007

Animal Model Shows Disease Progression Can Be Prevented

BERKELEY, Calif., Nov. 26 /PRNewswire-FirstCall/ -- In a paper appearing online in the December issue of The European Journal of Immunology (Vol. 37, Issue 12), Dynavax scientists report the results of studies made possible under a grant from the Alliance for Lupus Research (ALR). In the article entitled, "Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms", the data show that Dynavax's proprietary IRS 954, a specific inhibitor of two Toll-like receptors, TLR7 and TLR9, can prevent progression of disease when injected in the lupus prone (NZBxNZW)F1 mice. The authors observed a significant reduction of serum levels of nucleic acid specific autoantibodies, the hallmark of systemic lupus erythematosus. IRS 954 treatment also resulted in decreased proteinuria, glomerulonephritis and end-organ damage and increased survival, compared to untreated mice. A copy of the article is posted on http://www.dynavax.com/publications.htm.

According to Robert L. Coffman, Ph.D., Vice President and Chief Scientific Officer, "These results show that the previously reported ability of IRS 954 to block IFN-alpha translates into reduced symptoms in an animal model of lupus. The data support our hypothesis that blocking both TLR7 and TLR9 in B cells and in human plasmacytoid dendritic cells is a promising new approach for the treatment of lupus. The ability of IRS 954 to specifically intervene in the inappropriate immune signaling cascade that leads to autoimmunity may have application for other autoimmune diseases as well."

IRS 954 represents a novel class of oligonucleotides, named immunoregulatory sequences (IRS), that specifically inhibit the TLR-induced inflammatory response implicated in disease progression in lupus. In 2005, the A
'/>"/>

SOURCE Dynavax Technologies Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Dynavax Issued Landmark Patent Covering Second-Generation TLR9 Agonists
2. Dynavax to Present at UBS 2007 Global Life Sciences Conference
3. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
4. QMed, Inc. Reports July Medicare SNP Enrollments
5. Phlo Affiliate Reports Expanded Coverage to Oregon Border
6. Healthcare Technologies Reports Loss for 2007 Second Quarter & Six Months Results
7. Dragon Pharmaceutical Reports Growth in Sales and Profits during Second Quarter of 2007
8. Carrington Reports Second Quarter 2007 Results
9. Avitar Reports Third Quarter Financial Results for Fiscal 2007
10. Response Genetics Reports Second Quarter 2007 Financial Results
11. Cadence Pharmaceuticals Reports Second Quarter 2007 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Aug. 21, 2014  Decision Resources Group finds ... and Mexico ... several newly approved agents, the anticipated label extension ... the launch of emerging biologics will substantially increase ... the emerging IL-5 inhibitors will introduce a new dynamic ...
(Date:8/21/2014)... VIEW, Calif. , Aug. 21, 2014 /PRNewswire/ ... properties and behaviors based on external stimuli such ... poised to have a disruptive effect in multiple ... revolutionize the business landscape by printing objects ranging ... aerospace and automotive sectors. Logo - ...
(Date:8/21/2014)... August 21, 2014 SoundConnect ... been recognized as one of the nation’s Fastest ... magazine for the 2nd consecutive year. Inc. magazine ... annual Inc. 500|5000, an exclusive ranking of the ... most comprehensive look at the most important segment ...
(Date:8/20/2014)... have it that American Indians largely were wiped out ... and tuberculosis brought to the New World by European ... million people lived in the Americas shortly before Europeans ... by European diseases., But new research led by anthropological ... Krause of the University of Tubingen in Germany indicates ...
Breaking Biology Technology:Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3
... Pivotal VeraTag(TM) Study ... Initiated ... 4:30 p.m. ET --, SOUTH SAN FRANCISCO, Calif., Oct. 24 Monogram,Biosciences, ... 30, 2007. Third Quarter Results The Company had revenue of $10.4 ...
... Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ), a biopharmaceutical company ... the areas of hepatitis C and,oncology, announced today that ... November 1, 2007, after the U.S. financial markets,close. ... discuss its third,quarter financial results and operational highlights and ...
... Factors, MUNDELEIN, Ill., Oct. 24 ... has been awarded a hematology contract extension,by ... The,extension agreement provides MedAssets, customers access to ... October,1, 2007, said John Kershaw, President, Sysmex ...
Cached Biology Technology:Monogram Announces Third Quarter 2007 Financial Results 2Monogram Announces Third Quarter 2007 Financial Results 3Monogram Announces Third Quarter 2007 Financial Results 4Monogram Announces Third Quarter 2007 Financial Results 5Monogram Announces Third Quarter 2007 Financial Results 6Monogram Announces Third Quarter 2007 Financial Results 7Monogram Announces Third Quarter 2007 Financial Results 8Monogram Announces Third Quarter 2007 Financial Results 9Monogram Announces Third Quarter 2007 Financial Results 10Monogram Announces Third Quarter 2007 Financial Results 11Monogram Announces Third Quarter 2007 Financial Results 12Monogram Announces Third Quarter 2007 Financial Results 13Anadys Pharmaceuticals to Report Third Quarter 2007 Financial Results 2Sysmex America Awarded MedAssets Supply Chain Systems Hematology Contract Extension 2
(Date:8/21/2014)... of the water window? It consists of radiations in ... absorbed by the water in biological tissues. New theoretical ... radiations within the water window. These could be the ... image of the biological samples or to be used ... the physical mechanism needed to efficiently generate the harmonic ...
(Date:8/21/2014)... standards process, will be available soon and will improve ... in the OnlineFirst version of Nutrition in Clinical ... the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), ... misconnection that can be harmful and even fatal to ... medical devices, components, and accessories to deliver fluids or ...
(Date:8/21/2014)... a novel and versatile modeling strategy to simulate polyelectrolyte ... as well as for studying polyelectrolytes, including DNA and ... much larger and more complex polyelectrolyte systems, and to ... author of a paper on the work and a ... and Engineering. "This is a big step forward for ...
Breaking Biology News(10 mins):Water window imaging opportunity 2New feeding tube connectors will improve patient safety 2Researchers develop models to study polyelectrolytes, including DNA and RNA 2
... Bats use a combination of cues in their hunting sequence ... to attack, catch and consume and which ones they are ... Eavesdropping bats first listen to their prey, then they assess ... Dr. Rachel Page and her team from the Smithsonian Tropical ...
... Centre of Finland have in collaboration with the University ... Therapies Corp. and Pharmatest Services Ltd, discovered a novel ... and showed that heparin-like compounds can potentially be used ... These findings were published on the Molecular Cancer ...
... the University of Queensland has found a better way to ... to the May issue of the prestigious journal Nature ... called Acacia. Acacia analyses the output of next-generation gene ... Ts and Gs the ,bases, that code for DNA ...
Cached Biology News:What sounds good doesn't always taste good 2New approach to 'spell checking' gene sequences 2
Peptide-affinity Purified Polyclonal Antibody to SMAD7 Peptide with sequence SSCPCWLEVIFNSR, from C Terminus of the protein sequence according to NP_005895....
Purified anti-PXR...
Polyclonal Antibody to PRG3...
Goat polyclonal to MLH3 ( Abpromise for all tested applications). entrezGeneID: 27030 SwissProtID: Q9UHC1...
Biology Products: