Navigation Links
Draper Device Could Help Pave Way Towards “Kidney-On-A-Chip” Development
Date:6/29/2012

Cambridge, MA (PRWEB) June 28, 2012

Researchers designed a microdevice that will better simulate a biologically realistic growth environment for human kidney cells in the laboratory. The proof-of-concept for a "kidney-on-a-chip" could one day give scientists a more accurate platform for drug screening or disease modeling.

The microscale tissue modeling device, developed by scientists from Draper Laboratory and Boston University, is the first biomimetic platform to take into account both physical and fluid-flow effects on kidney cells and is a step toward one day replicating kidney organ function in the lab. Their work was published in 2012 in the journal Integrative Biology.

The kidneys are a pair of fist-sized organs that filter blood and are crucial to maintaining fluid balance, regulating blood pressure, and eliminating toxins. Disorders of the kidney can lead to high blood pressure and heart failure, and diabetics are particularly at risk - the World Heath Organization estimates that 10-20% of diabetes-related deaths are due to kidney failure.

The primary structural unit of the kidney, called a nephron, is a highly organized tubule under constant exposure to fluid-flow stress from the blood and fluids it filters. In addition, nephron cells receive cues from the extracellular matrix, a network of structural and signalling proteins. In the laboratory, kidney cells are typically grown on flat plastic or glass surfaces in a static nutrient broth, an unrealistic growth environment which can potentially affect cell function and physiology.

To create a more accurate environment, Else Frohlich, Draper Fellow and Boston University graduate student, and her advisors fabricated a plastic and silicone rubber microdevice comprised of a textured growth surface and a microfluidic chamber. The growth surface, lined with a series of submicron ridges and grooves coated with collagen, mimics topographical and protein cues from the extracellular matrix. On this surface, they grew a layer of cells from a segment of the nephron known as the renal proximal tubule, and provided fluid-flow stress cues with a microfluidic pump.

They found that the combination of topography and fluid-flow enhanced tissue structure formation, and in particular increased the intensity of tight junction formation between the cells, which better resembles kidney cells in the body. These tight junctions act as a seal for filtration and on flat control surfaces, were less well formed.

Frohlich received the President’s Award, the top prize at Boston University’s Science and Engineering Research Symposium, for her work on the project, which contributed to her master’s thesis.

“We’re pushing the cells toward more realistic behavior,” says Joseph Charest, director of the organ-assist and in vitro models programs at Draper. “You can then model how well they replace and transport fluids, look at disease progression, and test potential therapies.”

The team is currently improving the device design and is testing permeability of the kidney cells to compare with how they function in the body. They plan on screening drugs and adding more cell types from other segments of the nephron in the future. “Eventually the goal is to create a full nephron-on-a-chip,” says Frohlich.

Draper Laboratory

Draper Laboratory is a not-for-profit, engineering research and development organization dedicated to solving critical national problems in national security, space systems, biomedical systems, and energy. Core capabilities include guidance, navigation and control; miniature low power systems; highly reliable complex systems; information and decision systems; autonomous systems; biomedical and chemical systems; and secure networks and communications.

http://www.draper.com

Read the full story at http://www.prweb.com/releases/2012/6/prweb9643975.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved  

Related biology technology :

1. Medi-Solve Coatings Develops Masking Process for Medical Devices
2. West Wireless Health Institute Applauds House Passage of Bill to Streamline FDA Medical Device Approval Process, Expedite Mobile Medical App Guidance
3. CU-Boulder physicists use ultrafast lasers to create first tabletop X-ray device
4. Bio-hybrid device acts as thermostat to control systemic inflammation in sepsis
5. BioRestorative Therapies Announces Next Generation of Stem Cell Disc Delivery Device
6. New Revolutionary Femoral Access Site Closure Device Shows Unparalleled Efficacy, Safety & Ease of Use, in a Wide Range of Patients Including Patients With a Challenging Anatomy
7. First successful human results achieved: Implantable wireless microchip drug delivery device
8. Research at Rice University leads to nanotube-based device for communication, security, sensing
9. Powerful AAC Device With Intel® i7 Processor Enables Natural Communication for Stroke, ALS and Autism Patients
10. ResearchMoz: Logic Integrated Circuit (IC) Market to 2020 - Programmable Logic Devices (PLD) and Application Specific Standard Product (ASSP) Dominate with a 78% Market Share
11. New method for enhancing thermal conductivity could cool computer chips, lasers and other devices
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Draper Device Could Help Pave Way Towards “Kidney-On-A-Chip” Development
(Date:6/27/2016)... CLEVELAND , June 27, 2016  Global ... average 4.6 percent through 2020 to $7.2 billion.  ... (food and beverages, cleaning products, biofuel production, animal ... and biotechnology, diagnostics, and biocatalysts). Food and beverages ... gains driven by increasing consumption of products containing ...
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading software as ... Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio and video ... trial team. , Using the CONSULT module, patients and physicians can schedule a face ...
(Date:6/27/2016)... --  Ginkgo Bioworks , a leading organism design ... awarded as one of the World Economic Forum,s ... innovative companies. Ginkgo Bioworks is engineering biology to ... in the nutrition, health and consumer goods sectors. ... including Fortune 500 companies to design microbes for ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in ... peritoneal or pleural mesothelioma. Their findings are the subject of a new article on ... biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients that ...
Breaking Biology Technology:
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
Breaking Biology News(10 mins):