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Dow AgroSciences Confirms Efficacy of Zinc Finger Nucleases for Precise Genome Modification in Maize
Date:4/29/2009

Breakthrough technology could transform agricultural advancement

Indianapolis (PRWEB) April 29, 2009 - Scientists at Dow AgroSciences LLC, a wholly owned subsidiary of The Dow Chemical Company (NYSE:DOW), have demonstrated insertion of a gene for a herbicide-tolerant trait to a specific, pre-determined location in the maize genome confirming that precise modification is practical and feasible, according to new research published in the advanced online edition of the journal Nature.

The new development, EXZACT™ Precision Technology, is based on utilizing proprietary Zinc-Finger Nucleases™ (ZFNs) for trait engineering and establishes a new industry standard to enhance global crop production through precise genetic modification in plant species. It is the only technology capable of specifically targeting any DNA sequence, thereby providing flexibility and versatility in genetic research and enabling developers to add, delete or edit genes in plants. EXZACT™ Precision Technology enhances the efficient discovery and development of novel traits and solutions for crop production.

"EXZACT Precision Technology has the potential to re-define the future of agriculture, driving productivity gains globally and greatly enhancing sustainability in a major food crop such as maize. We have proven this technology and modified the crop to enhance nutritional benefits and herbicide tolerance which will produce real benefits to farmers and consumers over time," said Jerome Peribere, President and CEO of Dow AgroSciences. "This breakthrough illustrates Dow AgroSciences commitment to lead innovation in agriculture."

The addition of a herbicide tolerance gene was targeted to disrupt ZmIPK1 in corn, an especially attractive choice because ZmIPK1 encodes an enzyme that is involved in biosynthesis of phytate, a component of feed corn that is particularly difficult
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Dow AgroSciences Confirms Efficacy of Zinc Finger Nucleases for Precise Genome Modification in Maize
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