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Discovery provides new drug targets for malaria cure
Date:1/11/2010

he tide on the war against malaria and ultimately may help save millions of lives," said Dr Maughan.

"The transporter is normally essential to the survival of the malaria parasite and when mutated, provides the extra advantage of removing the drug chloroquine from its cell.

"We hope that understanding the normal role of the transporter in plants will be a key step in malaria research. Unlike in the plant, if the gene for the transporter is inactivated in malaria, the parasite dies, preventing more study into its role. The plant could therefore provide a useful tool in malaria research."

"These results describe the first missing link in understanding this class of proteins and could provide a two-pronged treatment approach- preventing malaria removing chloroquine from its cell and enabling the design of new drugs based on the shape of glutathione."


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Contact: Nerissa Hannink
nhannink@unimelb.edu.au
University of Melbourne
Source:Eurekalert

Page: 1 2

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