Navigation Links
Discovery of 'creator' gene for cerebral cortex points to potential stem cell treatments
Date:1/17/2008

Irvine, Calif. University of California, Irvine researchers have identified a gene that is specifically responsible for generating the cerebral cortex, a finding that could lead to stem cell therapies to treat brain injuries and diseases such as stroke and Alzheimers.

Dr. Edwin Monuki, doctoral student Karla Hirokawa and their colleagues in the departments of Pathology & Laboratory Medicine and Developmental & Cell Biology found that a gene called Lhx2 serves as the long-sought cortical creator gene that instructs stem cells in the developing brain to form the cerebral cortex. This portion of the brain is responsible for higher sensory and cognitive functions, such as language, decision-making and vision. Without this gene, cortical cells will not form.

This new understanding of Lhx2s role in cortical development can potentially be used in stem cell research efforts to grow new cortical neurons that can replace damaged ones in the brain, said Monuki, an assistant professor of pathology. This finding has implications for continuing efforts to help people recover from a stroke or slow the progress of neurodegenerative diseases.

Study results appear in the Jan. 18 issue of Science.

Lhx2 is among a group of genes called selector genes that act during key moments of embryonic and fetal development, directing stem cells to grow into specific parts of the body such as brain, blood and bone.

In tests on rodents, the researchers found that Lhx2s cortical selector activity is critical only during the stage when the developing cortex is made up of stem cells, not before or after. In addition, they found that cortical stem cells that dont express the Lhx2 gene turn into a different cell type called a hem cell that induces neighboring cells to become the hippocampus, the oldest part of the cortex in evolutionary terms and a major memory center of the brain.

Lhx2s role in cerebral cortex development has far-reac
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology technology :

1. ARCA Discovery, Inc. to Present at 26th Annual JPMorgan Healthcare Conference on January 8, 2008
2. DuPont Joint Venture with Chinese Biotech Firm Strengthens Gene Discovery Research Efforts
3. Vaccinex, Inc. Announces Award of Key Patent in Europe for its Antibody Discovery Technology (ActivMab(R))
4. Discovery Institute Bioethicist Lauds Breakthrough in Stem Cells Research that Eliminates Need for Human Cloning
5. Discovery of a new way to manipulate light a million times more efficiently
6. Senomyx Announces Conclusion of Discovery and Development Collaboration With Kraft Foods Global, Inc.
7. WHO Introduces the Helminth Drug Initiative With Special Supplement in the Expert Opinion on Drug Discovery
8. EpiCept to Present Pre-clinical Advances of Myc Oncogene Directed Drug Discovery at Assays and Cellular Targets Conference
9. Senex Biotechnology Announces Presentation of Alzheimers Disease Drug Discovery Effort
10. Agendia Acquires Rights to the Discovery of a Major Drug Resistance Mechanism in Breast Cancer Potentially Leading to a Herceptin(R) Sensitivity Test
11. New method of selecting DNA for resequencing accelerates discovery of subtle DNA variations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 29, 2014 Due to a misstatement posted ... the Adult Stem Cell Technology Center, LLC ( ASCTC ) ... cell therapy research that might benefit ALS patients. Because ... new stem cell technologies and therapeutic applications, FRC listed ASCTC ... Challenge donors who wish not to support research that ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 SPIE Fellow ... Physics and Optical Science and Director of the Center ... North Carolina at Charlotte, and co-founder and Chairman of ... serve as the 2015 Vice President of SPIE, the ... President Philip Stahl announced recent election results at the ...
(Date:8/28/2014)... August 28, 2014 “This kit has an ... screen from 0 to 150 ppb,” said Mark Tess, PhD, ... significant benefit to plant owners and USDA-GIPSA inspection agencies that ... commodities. Testing can take place in a matter of minutes ... the plant test the feed and grain before accepting it, ...
(Date:8/28/2014)... NEW YORK , Aug. ... announces that a new market ... its catalogue: Whole ... (Systems, Kits (Library Preparation, Target ... Technology (Sequencing by Synthesis), by ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13
... SAN FRANCISCO, Calif., March 11 Raven,biotechnologies, inc., ... development of monoclonal antibody therapeutics (MAbs) for cancer,today ... RAV12 Phase,1/2a trial has been accepted as a ... the American Society of Clinical Oncology (ASCO).,The presentation ...
... in Western Pennsylvania Earn Designation, PITTSBURGH, March ... Allegheny General Hospital, UPMC Presbyterian Shadyside and UPMC,Passavant ... Cancers., Complex and rare cancers comprise approximately ... it difficult for patients to locate or,research facilities ...
... Ltd. has announced,development of a chemically synthesized vaccine ... its patented Replikins(TM) technology.,When the vaccine was administered ... lethal Taura virus. The specificity of the protective,effect ... the active,regions in the vaccine, and as a ...
Cached Biology Technology:Raven Announces RAV12 Phase 1/2a Study Results To Be Presented at ASCO 2Raven Announces RAV12 Phase 1/2a Study Results To Be Presented at ASCO 3Highmark Blue Cross Blue Shield and National Association Name Area Hospitals as Blue Distinction Centers for Complex and Rare Cancers 2Highmark Blue Cross Blue Shield and National Association Name Area Hospitals as Blue Distinction Centers for Complex and Rare Cancers 3Replikins Oral Vaccine Synthesized in 7 Days Protects 91% of Shrimp Against a Lethal Virus 2
(Date:8/31/2014)... release is available in French . ... study just published in the prestigious Nature Neuroscience ... Research Centre of the Douglas Mental Health University Institute and ... neural circuitry and dynamic mechanisms controlling memory as well of ... a sub-region named the subiculum. , In 2009, they ...
(Date:8/29/2014)... Until recently, little has been known about what ... international team of scientists, one of whom is a ... by showing that genes controlling the development of the ... rabbit domestication., The study was published Aug. 28 in ... questions. It is online at http://www.sciencemag.org/ ., The ...
(Date:8/29/2014)... of connections in transcription factor networks (TFNs) to evaluate ... published in PLOS Computational Biology in August. ... to a network,s resilience against mutations. , "In ... TFN models has a greater effect on robustness than ... said Dov A. Pechenick, PhD, lead author and former ...
Breaking Biology News(10 mins):Memory and Alzheimer's: Towards a better comprehension of the dynamic mechanisms 2New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3Assortativity signatures of transcription factor networks contribute to robustness 2
... 26, 2010) Consumption of 100 percent fruit juice ... diet quality in children and teens, according to new ... meeting. Two new studies from researchers at the ... Medicine clearly highlight the benefits of drinking 100 percent ...
... On April 15, 2010 , Dr. Stipkala joined a panel ... hosted by the University of South Carolina ,s NanoCenter in ... capitalists from all over the Southeast who are active in the nanotechnology ... Dr. Stipkala and ...
... YELLOWKNIFE, NT APRIL 2010 High in the Mackenzie ... tools being revealed as warming temperatures melt patches of ice ... Tom Andrews, an archaeologist with the Prince of Wales ... International Polar Year Ice Patch Study, is amazed at the ...
Cached Biology News:Drinking 100 percent fruit juice is associated with improved diet quality in children 2Dr. Jeremy M. Stipkala, Patent Attorney, Speaks on USC NanoCenter Panel 2Ancient artifacts reveals as northern ice patches melt 2
... DEPC-treated Water is suitable ... is prepared by incubating with ... autoclaved to remove the DEPC.DNase/RNase-Free ... for use in all molecular ...
Water Distilled (Gibco™) is membrane filtered and endotoxin screened....
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
Immunogen: Human Respiratory Syncytial Virus (RSV) and Bovine Respiratory Syncytial Virus (BRSV) Fusion protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: