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Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach
Date:2/29/2012

BOSTON, MA February 29, 2012 TREM Rx, Inc., a biotechnology company with a proprietary technology platform for novel vaccines delivered to the skin, announced today the results of an in vivo preclinical study that shows, for the first time, that powerful cells of the immune system called TREMs (T Resident Effector Memory cells) prevalent in the skin can mediate a protective immune response that is far stronger than memory T cells that circulate in the bloodstream. The study was published in today's online edition of Nature and was led by TREM Rx scientific founder, Dr. Thomas S. Kupper, the Thomas B. Fitzpatrick Professor of Dermatology at Harvard Medical School, and chair of Dermatology at Brigham and Women's Hospital and the Dana Farber Cancer Institute.

This research and previous work by Dr. Kupper's group demonstrated that a stronger generalized T cell immune response, and in particular a more robust TREM response, can be produced by delivering a viral vaccine vector to the upper skin tissues, as compared to below the skin or into the muscle. This new research reveals why novel vaccines administered to upper layers of the skin in preclinical models have demonstrably better preventative and therapeutic efficacy over conventional vaccine injection into the muscles or bloodstream. TREM Rx has exclusive rights to this vaccine-relevant intellectual property as the basis for the company's proprietary technology platform for developing novel vaccines.

"Conventional vaccines are typically focused on optimizing the B cell arm of the immune system to create disease-fighting antibodies. In contrast, this study shows that a more effective path to immunity may be to engage this newly discovered part of the T cell arm of the immune system through a population of powerful immune cells that we now know reside in the skin, lung, gut, and other epithelial tissues," said Thomas S. Kupper, MD, senior author of the Nature paper.

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