Navigation Links
Direct induction of chondrogenic cells from human dermal fibroblast culture by defined factors
Date:10/19/2013

A research team led by Professor Noriyuki Tsumaki of the Center for iPS Cell Research and Application (CiRA) at Kyoto University and Dr. Hidetatsu Ohtani, a former CiRA member who now works as a post doctoral fellow at Osaka University Graduate School of Medicine, has succeeded in directly converting human dermal fibroblasts into induced chondrogenic cells (iChon cells) without passing through an iPS cell stage in a process known as direct reprogramming. This finding has been published in PLOS ONE on October 16, 2013.

Articular cartilage, which is made up of chondrocytes and extracellular material in the form of Type II, Type IX, and Type XI collagens and aggrecan, fulfills the functions of ensuring smooth joint movement and absorbing shocks. Cartilage has little regenerative capacity and is gradually lost due to injury, aging, and other factors.

Normal articular cartilage consists of hyaline cartilage, but when this is lost it is partially replaced by fibrous cartilage. Fibrous cartilage produces Type I collagen and loses the extracellular material structure specific to cartilage. To restore cartilage function, this means that either high-purity hyaline cartilage not containing fibrous cartilage must be prepared and transplanted into the site where cartilage has been lost, or fibrous cartilage must be converted in situ into hyaline cartilage.

One conceivable method of producing cartilage would be to induce it from iPS cells. Alternatively, if it were possible to convert fibroblasts directly into chondrocytes without an intermediate iPS cell stage, chondrocytes could probably be produced in a shorter period of time than via an iPS cell-based method.

In 2011, Professor Tsumaki and his team reported that, by inserting into mouse dermal fibroblasts two reprogramming factors (c-MYC and KLF4) and one cartilage factor (SOX9), they had achieved direct reprogramming into induced chondrogenic cells without passing through a
'/>"/>

Contact: Akemi Nakamura
cira-pr@cira.kyoto-u.ac.jp
81-753-667-000
Center for iPS Cell Research and Application - Kyoto University
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Fitzsimons Redevelopment Authority Rolls Out First Phase of Strategic Refocus With Appointment of Four Key Leaders in The Bioscience Industry to Its Board of Directors
2. InspireMD Elects Sol J. Barer, Ph.D. Chairman of the Board of Directors
3. Michael Cusumano, MITs Sloan Distinguished Professor of Management, Joins Quantum Leap Innovations Board of Directors
4. BioStorage Technologies Appoints New Member to Board of Directors
5. BioSpecifics Technologies Corp. Announces Appointment of George Gould to Board of Directors
6. Fate Therapeutics Announces the Appointment of William H. Rastetter as Chairman of its Board of Directors and Interim CEO
7. Ecology Coatings Develops Coatings Safe for Direct Contact with Food Products
8. Sinovac Announces Resignation of Chup Hung Mok from Board of Directors
9. Robert Farrell Joins Bionovos Board of Directors
10. Oxford BioTherapeutics Appoints C. Glenn Begley as a Senior Clinical Advisor and Non-executive Director
11. Berkeley Lab Director Paul Alivisatos wins Wolf Prize in Chemistry
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Direct induction of chondrogenic cells from human dermal fibroblast culture by defined factors
(Date:7/30/2015)... -- With over 60,000 customers across the globe, ISN improves the efficiency and effectiveness of ... than 60,000 safe and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More ... Headquartered in Dallas, TX , ISN has additional offices ...
(Date:7/30/2015)... ST. LOUIS, July 30, 2015 ... period in 2014) , Reported sales were $697 ... of 2014.  Sales grew organically by 8%, and changes ... Recent acquisitions increased sales by 1%. , By ... 8% in Applied and 11% in SAFC Commercial. ...
(Date:7/30/2015)... ... ... As part of its 2015 growth plan and as a follow up to the recently ... Whitehouse Laboratories is pleased to announce that it has begun construction on a new Microbiological ... will be strictly dedicated to basic USP 51, USP 61, and USP 62 testing specific ...
(Date:7/29/2015)... Sanofi, a global and ... quarter of 2015. CEO Olivier Brandicourt ... in different businesses. Watch video interview ... Topics covered in the interview include:  ... Performance drivers - Diabetes ...
Breaking Biology Technology:ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 2Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 4Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 5Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 6Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 7Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 8Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 9Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 10Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 11Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 12Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 13Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 14Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 15Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 16Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 17Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 18Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 19Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 20Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2
... , , , ... FOLD ) will announce second quarter 2009 financial results after the ... announcement will be followed by a live conference call and webcast ... Interested participants and investors may access the conference call at ...
... , ... Change at ... constant on a constant, ... 2009 basis rates H1 2009 basis rates, ...
... , ... in Cardiac Core Lab Industry , ... Rochester, NY (PRWEB) July 29, 2009 -- iCardiac Technologies, Inc., a leader in advanced ... of 45 million cardiac cycles for agency facing studies in a single month utilizing the ...
Cached Biology Technology:Amicus Therapeutics Announces Second Quarter 2009 Financial Results Release Date 2Sanofi-aventis Announces Second Quarter 2009 Results 2Sanofi-aventis Announces Second Quarter 2009 Results 3Sanofi-aventis Announces Second Quarter 2009 Results 4Sanofi-aventis Announces Second Quarter 2009 Results 5Sanofi-aventis Announces Second Quarter 2009 Results 6Sanofi-aventis Announces Second Quarter 2009 Results 7Sanofi-aventis Announces Second Quarter 2009 Results 8Sanofi-aventis Announces Second Quarter 2009 Results 9Sanofi-aventis Announces Second Quarter 2009 Results 10Sanofi-aventis Announces Second Quarter 2009 Results 11Sanofi-aventis Announces Second Quarter 2009 Results 12Sanofi-aventis Announces Second Quarter 2009 Results 13Sanofi-aventis Announces Second Quarter 2009 Results 14Sanofi-aventis Announces Second Quarter 2009 Results 15Sanofi-aventis Announces Second Quarter 2009 Results 16Sanofi-aventis Announces Second Quarter 2009 Results 17Sanofi-aventis Announces Second Quarter 2009 Results 18Sanofi-aventis Announces Second Quarter 2009 Results 19Sanofi-aventis Announces Second Quarter 2009 Results 20Sanofi-aventis Announces Second Quarter 2009 Results 21Sanofi-aventis Announces Second Quarter 2009 Results 22Sanofi-aventis Announces Second Quarter 2009 Results 23Sanofi-aventis Announces Second Quarter 2009 Results 24Sanofi-aventis Announces Second Quarter 2009 Results 25Sanofi-aventis Announces Second Quarter 2009 Results 26Sanofi-aventis Announces Second Quarter 2009 Results 27iCardiac Processes Volume of Data Equivalent to One Thousand Traditional Thorough QT Studies 2
(Date:7/23/2015)... BEDFORD, Mass., July 23, 2015 Aware, Inc. (NASDAQ: ... services, today reported financial results for its second quarter ended ... quarter of 2015 was $4.5 million, a decrease of 33% ...  Net income in the second quarter of 2015 was $0.3 ... million, or $0.04 per diluted share, in the same period ...
(Date:7/21/2015)... , July 21, 2015 Passwords ... as seen in the recent U.S. Office of ... solution to the infosec conundrum, but developers and ... stored. To address this dilemma, Biometrics-as-a-Service provider HYPR ... Biometric Tokenization SDK for third party integration. ...
(Date:7/9/2015)... SAN JOSE, Calif. , July 9, 2015 /PRNewswire/ ... human interface solutions, announced today that it will report ... 2015 on Thursday, July 30, 2015 after the close ... call for analysts and investors at 2:00 p.m. PT ... information.    To participate on the live ...
Breaking Biology News(10 mins):Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2
... Apricots are important to Turkey, the country where more ... the world. Looking to unlock the mystery of apricots, ... genetic relationship between apricot varieties. New research from a ... genetic link between Turkish and Hungarian apricot cultivars, yielding ...
... a recent issue of HortTechnology , Purdue University researchers ... study of the effects of a technique called "bulb dipping" ... applied as sprays or media drenches, bulb crops can be ... were designed to determine if dipping Easter lily bulbs in ...
... the XXI century. Recent data point to more than a ... 300 million are clinically obese. What is more, the rates ... 155 million children and adolescents being overweight, of which 40 ... what point corporal morphology was influenced by genetics, on the ...
Cached Biology News:Genetic relationship between Hungarian and Turkish apricots confirmed 2Bulb dipping controls Easter lily growth 2The amount of adipose tissue should be taken into account in the fight against obesity 2The amount of adipose tissue should be taken into account in the fight against obesity 3
... BIOLASE Core Kit contains all ... polymerase assays on a wide ... addition to dNTPs, the Core ... widely used BIOLASE DNA polymerase, ...
UGT1A7 (E-15)...
Canine Aortic Smooth Muscle Cells (CnAOSMC) (>500,000 cells)...
... to the third cytoplasmic loop of human ... KLH. The immunizing peptide has 79% homology ... Physical form: Solution in phosphate buffered saline, ... Titertest method: IHC (p). Titertest values: ...
Biology Products: