Navigation Links
Differing structures underlie differing brain rhythms in healthy and ill
Date:10/14/2011

Virtual brains modeling epilepsy and schizophrenia display less complexity among functional connections, and other differences compared to healthy brain models, researchers at Case Western Reserve University School of Medicine report.

The researchers worked backward from brain rhythms the oscillating patterns of electrical activity in the brain recorded on electroencephalograms - from both healthy and ill individuals.

These oscillations relate to the state of awareness. But, instead of seeking answers to how the rhythms emerge, the investigators built models that, when they reproduced the different neural activity patterns seen in real brains, revealed underlying structural differences among the healthy and ill.

Their work is published in the online journal PLoS Computational Biology.

"Our hypothesis is that healthy brains share features with the virtual healthy brains and unhealthy brains share features with virtual unhealthy brains," said Roberto Fernndez Galn, a professor of neurosciences at Case Western Reserve School of Medicine. Galn has a background in physics, electrophysiology and computational neuroscience.

Galn worked with G. Karl Steinke, a former graduate student in Biomedical Engineering at Case School of Engineering, and now a researcher at Boston Scientific Neroumodulation.

After breaking down the oscillating patterns of brain activity collected from real EEGs and MEGs into a usable form, the researchers applied inverse calculations and reverse engineering to develop brain models they refer to as virtual brains.

The most striking difference they found is in the hierarchical networks of brain connections among the models of healthy and unhealthy brains, Galn said. "The more complex the network, the more normal the EEG pattern."

"A healthy brain network is similar to the airport network," he explained. "There are a small number of hubs with many connections to othe
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Carbon nanotube structures changed by attack from within, researchers discover
2. Heated AFM tip allows direct fabrication of ferroelectric nanostructures on plastic
3. UBC researchers develop new model to predict the optical properties of nano-structures
4. Trapping a rainbow: Lehigh researchers slow broadband light waves with nanoplasmonic structures
5. Intricate, curving 3-D nanostructures created using capillary action forces
6. High-speed filter uses electrified nanostructures to purify water at low cost
7. Unprecedented look at oxide interfaces reveals unexpected structures on atomic scale
8. Empa grows sea urchin-shaped structures
9. Depth charge: Using atomic force microscopy to study subsurface structures
10. Biomedical Structures Receives Growth Capital from Ampersand Ventures to Fund Ongoing Expansion
11. Light twists rigid structures in unexpected nanotech finding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... lessons often have it that American Indians largely were ... pox, influenza and tuberculosis brought to the New World ... about 20 million people lived in the Americas shortly ... were killed by European diseases., But new research led ... and Johannes Krause of the University of Tubingen in ...
(Date:8/20/2014)... 2014  Decision Resources Group finds that the vascular access device ... , India and China ... equal to the size of the United States ... experience much faster growth as a result of strong economic expansion, ... key findings from Decision Resources Group,s coverage of the BRIC vascular ...
(Date:8/20/2014)... 2014 /PRNewswire-iReach/ -- A case study from Intel ... school,s bioengineering department and the Intel® Internet of ... Academic Program, UCSD,s research focuses on exploring the ... Photo - http://photos.prnewswire.com/prnh/20140819/137540 ... of Dr. Todd P. Coleman , Associate ...
(Date:8/19/2014)... 20, 2014 One of the ... is an inadequate vascular supply. Nutrient and gas ... tissues is critical for successful regeneration and integration ... mitigate deficiencies in vascularization and promote angiogenesis in ... optimizing scaffold design and architecture, and enhancing scaffolds ...
Breaking Biology Technology:Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2
... (PHPG) today reported its consolidated, audited, financial,results for its ... in fiscal year 2007 were a record at $15,100,000 ... the year was our,highest ever at $17,802,000 as was ... 2006, respectively., Pre-tax income for the year was ...
... March 31 BioMarin,Pharmaceutical Inc. (Nasdaq and SWX: ... marketing and distribution partner in Japan, has,received approval ... Japanese Ministry of Health, Labour and Welfare,(MHLW) for ... MPS,VI)., "We are proud to work with ...
... Initial Proceeds to be Used for Marketing in ... -- China Kangtai,Cactus Biotech Inc. (the "Company") (OTC ... and marketer of a,variety of cactus-based consumer products ... into an equity purchase agreement with T Squared,Investments ...
Cached Biology Technology:Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 2Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 3Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 4Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 5Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 6Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 7Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 8Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 9Naglazyme Approved by Japanese Ministry of Health 2Naglazyme Approved by Japanese Ministry of Health 3Naglazyme Approved by Japanese Ministry of Health 4China Kangtai Cactus Biotech, Inc. Obtains $500,000 Equity Financing 2
(Date:8/19/2014)... It,s not a lemur. It,s not an African Bush Baby ... tiny, adorable and downright "cool" primate from Southeast Asia. , ... with," said Rafe Brown, curator-in-charge at the University of Kansas, ... extremely cute, furry body; a long tail with a furry ... tips that look a bit like the disks on the ...
(Date:8/19/2014)... a new implantable tissue scaffold coated with bone growth ... When applied to bone injuries or defects, this coated ... that looks and behaves just like the original tissue. ... dramatic improvement over the current standard for treating bone ... the patient,s body a painful process that does ...
(Date:8/19/2014)... 19, 2014 ) -- Scientists at the Houston Methodist ... and transfer single cells using a pipette -- a ... this engineering feat and preliminary test results in a ... Chemical Society . , "Studying single cells and their ... research," said nanomedicine department. faculty member Lidong Qin, Ph.D., ...
Breaking Biology News(10 mins):Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 2Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 3Engineering new bone growth 2Engineering new bone growth 3Moving single cells around -- accurately and cheaply 2
... Canadian agriculture is faced with great opportunities, but ... expert panel convened by the Council of Canadian ... in Canada can be more sustainably managed by ... management strategies, adopting effective governance mechanisms, and harnessing ...
... Feb. 26, 2013   Althea Technologies, Inc. , ... services, and Profectus BioSciences Inc , a ... of a manufacturing supply agreement for plasmid DNA ... quantities of cGMP (current Good Manufacturing Practice) manufactured ...
... of Kansas researchers have found that the infants of mothers ... DHA during pregnancy weighed more at birth and were less ... 34 weeks gestation than infants of mothers who were given ... the dietary supplement during pregnancy. Susan CarlsonThe results are ...
Cached Biology News:Report: 'Water and Agriculture in Canada: Towards Sustainable Management of Water Resources' 2Althea Technologies & Profectus BioSciences Sign Manufacturing Agreement For Plasmid DNA Production 2Althea Technologies & Profectus BioSciences Sign Manufacturing Agreement For Plasmid DNA Production 3Prenatal DHA reduces early preterm birth, low birth weight 2
Phospho-FAK (Tyr576/577) Antibody...
... Anti-Natural Killer Cell Receptor-P1, ... Immunogen: Hybridoma produced ... from BALB/c mice immunized (BALB/c ... (LAK) cells and mouse myeloma ...
... to Yersinia pestis This antibody ... . Immunogen: Purified ... vaccine strain EV76. ... F1 capsular antigen. There is no ...
Rabbit polyclonal to ZFP200 ( Abpromise for all tested applications). Antigen: Synthetic peptide: CGKSFNHKTNLNKHER (Human) Entrez Gene ID: 7752 Swiss Protein ID: P98182...
Biology Products: