Navigation Links
Designer nano luggage to carry drugs to diseased cells
Date:3/9/2010

For the first time, scientists have succeeded in growing empty particles derived from a plant virus and have made them carry useful chemicals.

The external surface of these nano containers could be decorated with molecules that guide them to where they are needed in the body, before the chemical load is discharged to exert its effect on diseased cells. The containers are particles of the Cowpea mosaic virus, which is ideally suited for designing biomaterial at the nanoscale.

"This is a shot in the arm for all Cowpea mosaic virus technology," says Professor George Lomonossoff of the John Innes Centre, one of the authors on a paper to be published in the specialised nanotechnology scientific journal, Small.

Scientists have previously tried to empty virus particles of their genetic material using irradiation or chemical treatment. Though successful in rendering the particles non-infectious, these methods have not fully emptied the particles.

Scientists at the John Innes Centre, funded by the BBSRC and the John Innes Foundation, discovered they could assemble empty particles from precursors in plants and then extract them to insert chemicals of interest. Scientists at JIC and elsewhere had also previously managed to decorate the surface of virus particles with useful molecules.

"But now we can load them too, creating fancy chemical containers," says lead author Dr Dave Evans.

"This brings a huge change to the whole technology and opens up new areas of research," says Prof Lomonossoff. "We don't really know all the potential applications yet because such particles have not been available before. There is no history of them."

One application could be in cancer treatment. Integrins are molecules that appear on cancer cells. The virus particles could be coated externally with peptides that bind to integrins. This would mean the particles seek out cancer cells to the exclusion of healthy cells. Once bound to the cancer cell, the virus particle would release an anti-cancer agent that has been carried as an internal cargo.

Some current drugs damage healthy cells as well as the cancer, leading to hair loss and other side effects. This technology could deliver the drug in a more targeted way.

"The potential for developing Cowpea mosaic virus as a targeted delivery agent of therapeutics is now a reality," says Dr Evans.

The empty viral particles, their use, and the processes by which they are made, are the subject of a new patent filing. Management of the patent and commercialisation of the technology is being handled by PBL.


'/>"/>

Contact: Zoe Dunford
zoe.dunford@bbsrc.ac.uk
44-016-032-55111
Norwich BioScience Institutes
Source:Eurekalert

Related biology technology :

1. Designer molecules being developed to fight disease
2. Angela Shen-Hsieh of Visual I
3. O Named to Board of Directors of AIGA: Oldest and Largest Membership Organization for Designers
4. Celebrity Designer Ty Pennington to Host 10th Annual ADHD Experts on Call Program
5. Stem Cell Transplantation Research at The Cancer Center at Hackensack University Medical Center Aims to Develop Designer Transplants
6. New designer toxins kill Bt-resistant insect pests
7. Celebrity Designer Ty Pennington to Host ADHD Experts on Call Program
8. MultiVu Video Feed: Allergan, Inc. Partners With "Project Runway" Designer Kara Saun and Gen Art Fresh Faces In Fashion to Raise Awareness About Excessive Underarm Sweating
9. Natures Premium(R) Brand First Fresh Pork in North America to Carry DNA TraceBack(R) Seal of Authenticity
10. Cliff Consulting, Inc. Adds Two Influential Former Executives to Its Team - Banker Mary P. Carryer and Healthcare IT Leader Robert Goldstein
11. A hot road to new drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... ... Global Stem Cells Group has announced an inaugural conference and stem cell ... 24-March 6, 2016. The new facility will provide advanced protocols and state-of-the-art techniques in ... CEO Benito Novas will host the event, which will begin with a stem cell ...
(Date:2/12/2016)... FRANCISCO , February 12, 2016 ... Medicine Efforts by Enabling Scientific Understanding of Complex ... and Rare Diseases --> ... genomic diagnostics in South Asia and a leading provider ... would contribute $10 million to the GenomeAsia 100K ...
(Date:2/11/2016)... NEW YORK , Feb. 11, 2016  Bioethics International, ... how medicines are researched, developed, marketed and made accessible to ... BMJ Open had named the publication of the ... for 2015. The publication is also featured as one of ... published in the last year that are most frequently read. ...
(Date:2/11/2016)... February 11, 2016 ... or "Company") (OTCQB: PSID), a life sciences company ... its Thermomedics subsidiary, which markets the Caregiver® FDA-cleared ... plan in January 2016, including entering into agreements ... monthly sales growth, and establishing several near-term pipeline ...
Breaking Biology Technology:
(Date:1/22/2016)... DUBLIN , Jan. 22, 2016 /PRNewswire/ ... announced the addition of the "Global ... report to their offering. --> ... of the "Global Biometrics Market in ... offering. --> Research and ...
(Date:1/20/2016)... 2016 A market that just keeps on ... the explosion in genomics knowledge. Learn all about it ... range of dynamic trends are pushing market growth and ... - pharmacogenomics - pathogen evolution - next generation sequencing ... greater understanding of the role of genetic material in ...
(Date:1/20/2016)... 2016  Synaptics Incorporated (NASDAQ: SYNA ), ... announced sampling of S1423, its newest ClearPad ® ... screen applications including smartwatches, fitness trackers, and touch ... rectangular shapes, as well as thick and curved ... on screen, while wearing gloves, and supports swipes ...
Breaking Biology News(10 mins):