Navigation Links
Denosumab Demonstrates Superiority Over Zometa(R) in Delay of Complications Due to Bone Metastases in Advanced Breast Cancer Patients
Date:9/22/2009

perior to Zometa with respect to the first, on-study SRE, as well as the first-and-subsequent on-study SREs, and to assess the safety and tolerability of denosumab compared with Zometa.

About Denosumab and Amgen's Research in Bone Biology

Denosumab is the first fully human monoclonal antibody in late stage clinical development that specifically targets RANK Ligand, the essential regulator of osteoclasts (the cells that break down bone). With more than 19,000 patients in trials across indications worldwide, the denosumab development program is the largest ever initiated by Amgen. This broad and deep development program demonstrates Amgen's commitment to researching and delivering pioneering medicines to patients with unmet medical needs. Amgen is studying denosumab in numerous tumor types across the spectrum of cancer-induced bone disease. Over 11,000 patients have been enrolled in the denosumab oncology clinical trials, testing the drug for the reduction of SREs in breast cancer patients, for the amelioration of treatment-induced bone loss in patients with breast or prostate cancers, for the prevention of SREs due to the spread of cancer to the bone in patients with multiple myeloma or those suffering from a variety of solid tumors, and for its potential to delay bone metastases in prostate cancer.

Bone Metastases: Impact and Prevalence

Bone metastases, cancer cells that separate from tumors and migrate to bone tissue where they settle and grow, occur in more than 1.5 million people worldwide.(2) With improvements in cancer care, including earlier diagnosis and new treatment options, leading to increases in survival rates(3), the number of patients developing metastatic disease secondary to a primary cancer is increasing. Bone metastases are a significant problem for patients with certain types of advanced cancer, with incidence rates of nearly 100 percent in myeloma patients and as high as 75 per
'/>"/>

SOURCE Amgen
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related biology technology :

1. Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO)
2. FDA Accepts Amgens Submission and Files Biologics License Application for Denosumab
3. ER Doctor Demonstrates Breast Pump on Live TV with Patented New Freemie Hands-Free System
4. NexBio(R) Demonstrates DAS181 (Fludase(R)*), a Broad-Spectrum Drug Candidate, Inhibits Influenza Viral Infection in Human Lung Tissue
5. Data Published in Cell Stem Cell Demonstrates Potent Anti-Cancer Activity for OncoMed Pharmaceuticals Lead Antibody
6. Abbott HIV Test Demonstrates Earlier Disease Detection
7. BioNeutrals Ygiene(TM) Hospital Grade Antimicrobial Demonstrates a 99.9997% Kill Rate Against Clostridium Difficile Spores (C.diff) in Independent Lab Pre-testing Phase
8. New Pre-Clinical Data on OmniGuides BeamPath NEURO(TM) Demonstrates Precise Cutting in Brain Tissue
9. Phase II Trial Demonstrates Elacytarabine May Increase Survival Threefold in Patients With Late-Stage Leukaemia
10. PROSTVAC(TM) Data Presented at the ASCO Meeting Demonstrates the Potential for Significant Increases in Life Expectancy in Late-Stage Prostate Cancer
11. NIMOTUZUMAB DEMONSTRATES EFFICACY IN RANDOMIZED HEAD & NECK CANCER STUDY WITHOUT THE TOXICITIES ASSOCIATED WITH OTHER EGFR DRUGS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Pittsburgh, PA (PRWEB) January 15, 2014 The ... Company, publisher of Food Safety Tech , an e-Journal ... has signed an agreement for the second year for the ... with Pittcon 2014. The partnership provides that the registration fee ...
(Date:1/15/2014)... JOSE, California , January 15, 2014 ... cancer, today announced the appointment of Thomas C Reynolds MD, ... 20 years, development experience gained in the biotechnology industry, most ... "I am delighted to welcome Tom at this transformative time ...
(Date:1/15/2014)... 2014 More than 5 million Americans ... in 3 seniors will die with Alzheimer’s or another ... figures have shocked many Americans into looking for ways ... these tragic age-related cognitive disorders. Jonathan Weisman, president of ...
(Date:1/15/2014)... 2013 was a banner year of ... They saw continued independent research led by the team ... a $1 million grant from the Susanne Marcus Collins ... a peer reviewed journal, Amy Grant highlighted Brainwave Optimization® ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... N.C., March 25 TeleHealth Services, the ... solutions to hospitals, today announced that it has been ... system,s strategy to enhance the hospital stay for patients ... improving the hospital experience by being progressive and consumer ...
... /PRNewswire-FirstCall/ - Spectral Diagnostics Inc. (TSX:SDI), a company ... announced that the 29th International Symposium on Intensive ... March 24-27, 2009 will feature a key scientific ... include presentations from six thought leaders in the ...
... Senator Katherine Laforge. With stakes higher than they,ve ever been before, Batman ... America to OPEC forever. The message that Batman and Senator Katherine Laforge ... from OPEC and put an end to financing our own destruction. , ... (Vocus) March ...
Cached Biology Technology:TeleHealth Services and Lakeland HealthCare Connect to Create Outstanding Patient Experience 2TeleHealth Services and Lakeland HealthCare Connect to Create Outstanding Patient Experience 3Spectral announces presentations at the 29TH International Symposium on Intensive Care and Emergency Medicine focusing on the role of endotoxin 2Batman Teams with Senator Katherine Laforge to Help Free America from OPEC 2Batman Teams with Senator Katherine Laforge to Help Free America from OPEC 3Batman Teams with Senator Katherine Laforge to Help Free America from OPEC 4Batman Teams with Senator Katherine Laforge to Help Free America from OPEC 5
(Date:4/23/2014)... a signing ceremony in Buenos Aires yesterday, Argentina ... an associate member state. The move strengthens the ... science communities. It grants Argentinian scientists access to ... beneficial collaborations. , "Ever since its inception, fostering ... have been at the core of EMBL,s mission," ...
(Date:4/23/2014)... Sophie Martin of the University of Lausanne, Switzerland, as ... award acknowledges her work to understand the molecular events ... , Martin has been working for the past 15 ... in which the spatial organization of cells contributes to ... years, she has been using fission yeast, which grow ...
(Date:4/23/2014)... a University of Exeter researcher has shed light on ... thriving in Australia,s remote outback have become reviled as ... Crowley, of the Environment and Sustainability Institute at the ... the camel in Australia, from their historic role helping ... status as unwelcome "invader." , The deserts of the ...
Breaking Biology News(10 mins):EMBO Gold Medal 2014 awarded to Sophie Martin 2How Australia got the hump with 1 million feral camels 2How Australia got the hump with 1 million feral camels 3
... Scientist Jiř Friml from VIB and Ghent University, ... the Krber European Science Award, worth 750 000 euro. ... pursuing particularly innovative research projects. Friml gets the prize ... plants. "Friml,s work on the genetic, molecular and ...
... consequences of emerging infectious diseases on crops in ... are often underestimated, according to a new study ... Institute of the Science of Food Production in ... international communities to establish better mechanisms for monitoring ...
... COLUMBIA, Mo. A University of Missouri doctoral student has ... to take some of the guesswork out of wetland identification. ... of Engineers, manual on wetlands identification is 143 pages long. ... wetlands aren,t always wet. One important tool is looking at ...
Cached Biology News:VIB-UGent scientist Jiri Friml receives Koerber European Science Award 2010 2Plant disease -- more than a crop killer 2Taking the guesswork out of soil classification 2Taking the guesswork out of soil classification 3
... leader in electroporation products and specialty electrodes, ... line for experiment optimization and large volume ... breakthrough in Molecular Delivery. The days of ... typically limited the number of samples and ...
... Sequencer 20 System revolutionizes DNA sequencing, delivering ... The Genome Sequencer 20 System includes: ... and consumables for library construction, amplification, and ... de novo assembly The ...
... and size analyzer offering a wide dynamic range. ... in mind. It is comprised of a chemically ... The system is completely computer controlled. The modular ... such as dry or where smaller volumes are ...
... Kit provides a fast and simple procedure for ... other detergents from small samples of protein. The ... resin as an ion exchanger. Each column is ... acidic or basic protein.A complete kit for acidic ...
Biology Products: