Dendreon Reports Third Quarter 2008 Financi...(n as D9902B) clinical trial desi...)

designed to assess the safety and efficacy of the investigational

active cellular immunotherapy PROVENGE(R) (sipuleucel-T) in men with

metastatic androgen-independent prostate cancer. While Dendreon

remains blinded to the data, the independent data monitoring

committee (IDMC) reported to Dendreon a 20 percent reduction in the

risk of death in the PROVENGE arm relative to placebo (Hazard

Ratio= 0.80; 95% Confidence Interval [0.610-1.051]). The IDMC

observed no safety concerns and recommended that the study continue

to its final analysis, which is expected to be completed in mid-2009.

* Presented preclinical data on the Company's lead small molecule

candidate, D-3263, which targets Trp-p8 (a transmembrane cation

channel protein also known as Trp-M8), supporting Trp-p8 as a

therapeutic cancer target. Dendreon plans to file an Investigational

New Drug (IND) application later this year with the U.S. Food and

Drug Administration (FDA) to evaluate D-3263 in a Phase 1 dose

escalation study in cancer.

* Initiated a Phase 2 trial of PROVENGE called ProACT (PROstate Active

Cellular Therapy) or P07-2. The multicenter trial is enrolling 120

patients with metastatic, androgen independent prostate cancer.

* Initiated a Phase 2 trial of PROVENGE in men with localized prostate

cancer who are scheduled to undergo a radical prostatectomy. The

single-center trial called NeoACT (NEOadjuvant Active Cellular

immunoTherapy), or P07-1, which is being conducted at UCSF Helen

Diller Family Comprehensive Cancer Center, is enrolling

approximately 40 patients.

* In lieu of Dendreon's regularly scheduled quarterly conference call,

the Company will present at two upcoming investor c
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