Navigation Links
Defending against chemical acts of terrorism
Date:4/20/2012

ions into the gene encoding a target enzyme, in this case PON1. The mutated versions of the gene are then put back into bacteria, which produce the enzymes for testing. The goal was to end up with enzymes capable of detoxifying G-type nerve agents before those nerve agents could reach their target and cause harm. Those that passed the initial test went on to further rounds of evolution and testing.

After four rounds of evolution, the researchers obtained PON1 variants that worked up to 340 times better than those produced previously. Overall, the researches reported that the PON1 variants showed 40- to 3,400-fold higher efficiency than the normal enzyme in metabolizing the three most toxic G-type nerve agents.

These new and improved PON1 enzymes have become promising candidates for use as preventive and postexposure treatments in the event of a terrorist attack.

"We hope that our enzymes would be able to act together with currently available drugs to improve survival rates following intoxication," Goldsmith said. More broadly, the findings show the power of laboratory evolution to completely reshape existing enzymes for a variety of uses.


'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related biology technology :

1. 3M Withdraws Blackmail Claims Against Harvey Boulter From New York Court
2. Nanosurgery and the fight against cancer: Major breakthrough at Polytechnique Montral
3. Synergy Pharmaceuticals, Inc. Files Suit Against Ironwood Pharmaceuticals, Inc. and its Chief Scientific Officer and Senior VP of R&D, Dr. Mark G. Currie
4. MU researchers identify key plant immune response in fight against bacteria
5. Fox Insurance Company Awarded $3.3 Million in Arbitration Against Former Pharmacy Benefit Manager
6. Stemline Therapeutics, Inc. Announces Two Poster Presentations of SL-401 Efficacy Data Against Lymphoid Cancers at the 53rd Annual Meeting of the American Society of Hematology (ASH)
7. Taksta™ (fusidic acid) Demonstrates Activity Against MRSA Isolated From Cystic Fibrosis Patients
8. SomaGenics sshRNA Technology Demonstrates Efficacy of RNAi Against Hepatitis C Virus
9. Kelly Price Joins Los Angeles County Affiliate of Susan G. Komen for the Cure in the Fight Against Breast Cancer
10. World Hepatitis Alliance Warns that Stigma is a Major Threat to New Initiative Against Hepatitis Epidemic
11. Trudeau Institute announces a discovery in the fight against sepsis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Today the Academy of Model Aeronautics (AMA) ... of Appeals for the D.C. Circuit challenging the FAA’s Interpretation ... Federal Register on June 25, 2014. , The AMA ... text and intent of the FAA Modernization and Reform Act ... on any new rules or regulations regarding model aircraft that ...
(Date:8/22/2014)... direct observations of how facets form and develop ... sophisticated and effective nanocrystal design and reveal that ... growth breaks down at the nanoscale. , Researchers ... Berkeley National Laboratory (Berkeley Lab) used highly sophisticated ... camera to capture the physical mechanisms that ...
(Date:8/22/2014)... 2014 Research and Markets has ... Gel Permeation Chromatography (GPC) Industry Report 2014" report ... China Gel Permeation Chromatography (GPC) Industry Report is a ... the global gel permeation chromatography industry with a focus ... basic overview of the industry including definitions, classifications, applications ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 The ... model organisms can be accelerated by exome sequencing. ... manufacturing technologies, the custom SeqCap EZ Developer system ... , Mr. Watson will additionally present how he ... commercially available human and mouse exome kits. With ...
Breaking Biology Technology:AMA Files Petition for Review of FAA’s Interpretive Rule 2Shaping the future of nanocrystals 2Shaping the future of nanocrystals 3Shaping the future of nanocrystals 4Global and China Gel Permeation Chromatography (GPC) Industry Report 2014 2Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2
... Cedara Software said it has acquired through ... medical software company in Paris. Cedara is he Toronto-based ... information technology company headquartered in Milwaukee. , ,It will ... managment, which has been installed in 25 French facilities. ...
... revenues for the quarter ended December 31 were up 18 ... quarter, compared to $1.6 million a year ago. , ,A ... this year and projected cashflow break-even sometime in the next ... net loss was $1.6 million for the quarter, compared to ...
... Fifty-two University of Wisconsin undergrads are going to ... Thursday and Friday for creative inventions that could turn ... for Creativity and Tong Prototype Prize reward students for ... At this year's Innovation Days, undergrads will show off ...
Cached Biology Technology:
(Date:8/21/2014)... international standards process, will be available soon and will ... published in the OnlineFirst version of Nutrition in ... of the American Society for Parenteral and Enteral Nutrition ... of misconnection that can be harmful and even fatal ... join medical devices, components, and accessories to deliver fluids ...
(Date:8/21/2014)... have developed a novel and versatile modeling strategy to ... new materials as well as for studying polyelectrolytes, including ... to model much larger and more complex polyelectrolyte systems, ... Li, lead author of a paper on the work ... Materials Science and Engineering. "This is a big step ...
(Date:8/20/2014)... a study of 158 pregnant teenagers in Rochester, NY, ... intentional consumption of ice, cornstarch, vacuum dust, baby powder ... Cornell study. , Moreover, such teens had significantly lower ... eat nonfood substances. , Pregnant teens, regardless of pica, ... lead to iron deficiency and anemia. Low iron in ...
Breaking Biology News(10 mins):New feeding tube connectors will improve patient safety 2Researchers develop models to study polyelectrolytes, including DNA and RNA 2Pica in pregnant teens linked to low iron 2
... High-intensity focused ultrasound emitted in short pulses is ... to cancerous cells without destroying healthy tissue, according ... the journal Radiology. , High-intensity focused ultrasound (HIFU) ... destroy tumors through long and continuous exposures that ...
... grow these cells are costly and don't produce cells ... embryonic stem cells, said Shang-Tian Yang, a professor of ... Federal rules forbid the federal funding of research on ... the National Institutes of Health's Human Embryonic Stem Cell ...
... of the NIH public access policy announced earlier this ... , BioMed Central welcomes the announcement of the ... The NIH calls on all of its grantees to deposit ... of Medicine's PubMed Central and make them freely available within ...
Cached Biology News:Pulsating ultrasound enhances gene therapy for tumors 2Researchers devise way to mass-produce embryonic stem cells 2Researchers devise way to mass-produce embryonic stem cells 3BioMed Central welcomes the new National Institutes of Health public access policy 2
Rabbit polyclonal to TRPM8 (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 79054 SwissProtID: Q3YFM7...
Phospho- (Ser/Thr) PDK1 Docking Motif (18A2) Mouse mAb...
Component in MasterPure™ Purification Kits...
Chlamydia pneumoniae (TWAR)...
Biology Products: