Navigation Links
Decellularized mouse heart beats again after regenerating with human heart precursor cells
Date:8/14/2013

PITTSBURGH, Aug. 13, 2013 For the first time, a mouse heart was able to contract and beat again after its own cells were stripped and replaced with human heart precursor cells, said scientists from the University of Pittsburgh School of Medicine. The findings, reported online today in Nature Communications, show the promise that regenerating a functional organ by placing human induced pluripotent stem (iPS) cells which could be personalized for the recipient in a three-dimensional scaffold could have for transplantation, drug testing models and understanding heart development.

In the United States, one person dies of heart disease every 34 seconds, and more than 5 million people suffer from heart failure, meaning a reduced ability to pump blood, said senior investigator Lei Yang, Ph.D., assistant professor of developmental biology, Pitt School of Medicine. More than half of heart disease patients do not respond to current therapies and there is a scarcity of donor organs for transplant.

"Scientists have been looking to regenerative medicine and tissue engineering approaches to find new solutions for this important problem," Dr. Yang said. "The ability to replace a piece of tissue damaged by a heart attack, or perhaps an entire organ, could be very helpful for these patients."

For the project, the research team first "decellularized," or removed all the cells, from a mouse heart, a process that takes about 10 hours using a variety of agents. Then, they repopulated the remaining heart framework, or scaffold, with multipotential cardiovascular progenitor (MCP) cells. These replacement cells were produced by reverse engineering fibroblast cells from a small skin biopsy to make induced pluripotent stem cells and then treating the iPS cells with special growth factors to further induce differentiation.

"This process makes MCPs, which are precursor cells that can further differentiate into three kinds of cells the heart uses, including cardi
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology technology :

1. New Online Course Explores Mouse as Model for Prostate Cancer
2. GeneTex Introduces New Mouse Monoclonal Antibody Against the Ten-Eleven Translocation 1 (TET1) Protein for DNA Methylation/Epigenetics Research
3. A Long-Awaited Mouse Offers a New Animal Model for FSH Muscular Dystrophy
4. University of Colorado Cancer Center Study Shows that Bitter Melon Juice Prevents Pancreatic Cancer in Mouse Models
5. The Veterinary Bioscience Institute Announces a Mouse Surgery Webinar Series
6. Kymab Announces Launch of Kymouse HK
7. SPX-106T Arrests Development of Atherosclerotic Plaques in Mouse Model of Cardiovascular Disease
8. A mouse model brings new perspectives on Lafora disease
9. Over 50% of “Best Heart Hospitals” in U.S. News & World Report Are Certified to Implant the SynCardia Total Artificial Heart
10. 1st Pediatric SynCardia Total Artificial Heart Patient in Turkey Celebrates 18th Birthday
11. Robots Strike Fear in the Hearts of Fish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... 20, 2015 Research and Markets ... the "2015 Global Survey on Flow Cytometry ... The primary goal of this research is ... and reagents. Key information the survey seeks to ... flow cytometers, predominantly used applications for flow cytometers, ...
(Date:5/21/2015)... Tunnell Consulting, Inc. today ... senior statistician and Principal, a position to which she ... management and analysis of complex and large data sets ... “We’re delighted to have Julia join the Tunnell team ... Dr. Philippe Cini, Group Vice President and leader of ...
(Date:5/20/2015)... 2015 This year has been one ... US Patented Pearl’s Premium Ultra Low Maintenance Lawn ... country that are coming out of record bad weather. ... of major global concerns related to water, health, and ... the alternative to the standard, water-wasting, chemical-treated standard lawn. ...
(Date:5/20/2015)... The global genotyping market is expected to grow at ... 2015 to 2020 to reach $17.0billion in 2020. Genotyping ... development process and to provide personalized therapy, factors that ... by key manufacturers to offer advanced and innovative products ... 113 market data tables & 37 figures spread through ...
Breaking Biology Technology:Global Survey on Flow Cytometry Adoption Trends 2015 2Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Breakthrough 4th Generation Low Maintenance Lawn Seed Offers Solution to California Drought 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 3Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 4Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 5
... opportunities for micro and nano technologies. These challenges are ... the control and understanding of their behaviour. , This ... fibre analysis at the micro and nano-scale using state-of-the ... techniques. , Topics include fundamental effects of topography in ...
... Q1 2007, to RMB55.5 ... income grew 22.4%, as compared to Q1 2007, to RMB14.2 ... (US$2.0 million) - Q1 2008 net income grew 22.3%, as compared to Q1 2007, to RMB ... million (US$2.8 million), SHENYANG, China, May 14 /Xinhua-PRNewswire-FirstCall/ -- ...
... Acquisition Co., LLC,MDAC is proud to announce that it ... and proven success optimizing investments in,the medical device market ... include:, Tony Dimun, CEO of Nascent Enterprises, LLC, ... Larry Gold, PhD, Chairman and CEO of SomaLogic Inc., ...
Cached Biology Technology:Micro and Nano Scale Characterization of Fibers 23SBio Inc. Announces First Quarter 2008 Results 23SBio Inc. Announces First Quarter 2008 Results 33SBio Inc. Announces First Quarter 2008 Results 43SBio Inc. Announces First Quarter 2008 Results 53SBio Inc. Announces First Quarter 2008 Results 63SBio Inc. Announces First Quarter 2008 Results 73SBio Inc. Announces First Quarter 2008 Results 83SBio Inc. Announces First Quarter 2008 Results 93SBio Inc. Announces First Quarter 2008 Results 103SBio Inc. Announces First Quarter 2008 Results 113SBio Inc. Announces First Quarter 2008 Results 12MEDdevice Acquisition Co., LLC Announces Board Members and Advisors 2
(Date:5/19/2015)... 2015 Fingerprint Cards (FPC) has received ... FPC1155 and FPC1035 from one if its module partners. Deliveries ... Q3 2015 and the sensors will be used by smartphone ... for 2015 hereby amount to 740 MSEK to date. In ... MSEK and a number of smaller orders not separately communicated ...
(Date:5/18/2015)... -- Fingerprint Cards (FPC) has received an order ... FPC1035 from one if its module partners. Deliveries are planned ... and the sensors will be used by smartphone manufacturers in ... hereby amount to 740 MSEK to date. In addition to ... a number of smaller orders not separately communicated amounting to ...
(Date:5/11/2015)... May 11, 2015  Synaptics Incorporated (NASDAQ: ... solutions, today announced the appointment of Wajid ... Financial Officer, reporting to Rick Bergman , ... Chief Financial Officer, Kathleen Bayless , who ... Mr. Ali brings extensive financial management expertise ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... Institute of Dental and Craniofacial Research (NIDCR), part of ... new piece to the puzzle of how tumor cells ... abnormal growth, a well-known process called angiogenesis. , As ... Cell, the scientists found that in addition to the ...
... for Clinical Pathology (ASCP) announced that the Society will ... to provide laboratory training and quality improvement programs in ... programs are for medical laboratory professionals in Africa and ... for AIDS Relief. , The funding comes ...
... in the brains of monkeys that assesses the level ... gained from experiments in which they gave the monkeys ... could give insights into why humans compulsively engage in ... overeating. , The researchers, Michael Platt and Allison McCoy, ...
Cached Biology News:New lead reported in tumor angiogenesis 2New lead reported in tumor angiogenesis 3Laboratory professionals in Africa receive training under AIDS Relief Plan 2Gambling monkeys give insight into neural machinery of risk 2Gambling monkeys give insight into neural machinery of risk 3Gambling monkeys give insight into neural machinery of risk 4