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De nouvelles études établissent un lien mortel entre l'alcool, le poids et les maladies hépatiques chez la femme
Date:4/24/2013

233;vidence un lien étroit entre le développement d'un carcinome hépatocellulaire (CHC) chez des patients atteints d'une cirrhose d'origine alcoolique et la stéatohépatite métabolique.[3] Cette étude a montré que les patients atteints d'une cirrhose alcoolique qui sont également atteints d'une stéatose hépatique et en surpoids, obèses ou diabétiques de type 2 sont plus susceptibles de développer un CHC.

Dans cette étude, 100 patients ayant reçu une greffe pour une maladie hépatique d'origine alcoolique en phase terminale ont été examinés afin d'analyser l'impact combiné de la stéatose hépatique et des facteurs de risque métaboliques comme l'obésité et le diabète de type 2 sur le développement du CHC chez les patients.

Les résultats ont montré qu'une proportion plus importante de patients atteints d'un CHC était fréquemment en surpoids (54 % contre 14 % de patients non atteints d'un CHC) ou diabétique (43 % contre 22 % de patients non atteints d'un CHC). La moitié (50 %) des patients qui étaient atteints de stéatose hépatique et en surpoids, obèses ou diabétiques de type 2 avaient un CHC tandis que seulement 6 % des patients ne présentant pas ces autres conditions étaient atteints d'un CHC.

Le Dr Prati a commenté : « Nous savons depuis longtemps que la stéatose hépatique et l'alcool sont des facteurs de risque du CHC mais cette étude a permis d'évaluer leur effet combiné chez des patients atteints d'une cirrhose alcoolique. Ces observations montrent que les patients souffrant d'une cirrhose alcoolique qui présentent également des antécédents de stéatose hépatique, d'obésité ou de diabète de type&#
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SOURCE The European Association for the Study of the Liver (EASL)
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