Navigation Links
Data mining algorithm explains complex temporal interactions among genes
Date:6/24/2010

ral metabolic and cell cycle relationships in the datasets studied. "Through our temporal models, we have shown that S. cerevisiae reacts in a somewhat unified fashion, with cellular fate depending on core metabolism and cell division," the authors write in their paper.

"The metaphor that emerges from this analysis is that the metabolic state of the cell is essentially a fuel gauge, and there must be enough 'fuel in the tank' before permitting another key biological process, such as reproduction, to commence," said Helm. "The availability of energy controls whether a yeast cell divides or not."

"Our tools bring out the nature of temporal 'hardwiring' manifest in biological processes," said Ramakrishnan.

Helm adds: "In particular, they open up questions related to whether it would be possible to manipulate the system to adopt an aberrant cell state or make it proceed along a desired temporal order. The identification of well-defined states, such as found in hydrogen peroxide treatments, suggests that at this stage it may be possible to force the organism to adopt aberrant states."

For instance, the biotechnology industry currently employs microbes for a number of important commodity and specialty compounds, ranging from biofuels to pharmaceutical products. If cell division could be unlinked from metabolism, the microbial system would only need nutrients for maintaining metabolism, with fewer resources diverted to cell division. "This scenario would reduce overall bioproduction costs for the chemical of interest," said Helm.

Ramakrishnan, Mishra, and co-author Marco Antoniotti, associate professor of computer science with the University of Milan, are also inventors on a US patent application about GOALIE for which a notice of allowance has been issued. "We hope in the future our work can become key to understanding other important phenomena, like disease progression, aging, host-pathogen interactions, stress responses, an
'/>"/>

Contact: Susan Trulove
strulove@vt.edu
540-231-5646
Virginia Tech
Source:Eurekalert

Page: 1 2 3 4

Related biology technology :

1. DNA Genotek's Oragene●ANIMAL DNA Collection Kit Plays Key Role in Determining the Genetic Cause of Chiari Malformation in Dogs
2. Transgenomic Awarded SBIR Grant to Support Development of SURVEYOR(R) Endonuclease Adaptor-ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation
3. Top Biopharma Company Adopts BioFortis Translational Research Software for Centralized Management and Mining of Clinical Biomarker Data
4. Transgenomic Introduces SURVEYOR(R) Endonuclease Adaptor-Ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation
5. U.S. PTO Reexamining Lumenis Patents
6. Landfill mining reduces environmental impact of growing waste
7. Landfill mining reduces environmental impact of growing waste
8. Landfill Mining
9. Detection of potentially deadly atrial fibrillation dramatically improved by new algorithm
10. DNA2.0 Awarded US Patents for Breakthrough Gene Optimization Technology -- Company's Unique Algorithm Enables Expression Yields up to 50 Times Greater than Competing Approaches
11. Bioheart, Inc., Announces Letter of Intent to Acquire MEDICALGORITHMICS, Ltd.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014 BioHealth Innovation, Inc. (BHI), ... innovations and increasing access to early-stage funding in ... capitalist, Tania Fernandez , Ph.D., has joined the ... be a member of the management team for a ... $50 million in seed and early-stage equity investments to ...
(Date:9/30/2014)... September 30, 2014 The custom stainless ... Boston Product Show 2014. The Boston Area Chapter of ... 23rd annual, day-long event for Wed., Oct. 1 at ... to be the largest in ISPE Boston’s long history, ... of 3,000 attendees expected. , HOLLOWAY AMERICA President ...
(Date:9/30/2014)... On September 11, Pharma IQ conducted an ... of a session that he will lead on “Stem Cells” ... February 17-18, 2015 in London. In the interview posted ... Sherley to respond to several questions on the current state ... stem cell toxicity, and future trends in the use of ...
(Date:9/30/2014)... Pittsburgh PA (PRWEB) September 30, 2014 ... Nurses ( IACRN), a non-profit organization based ... Clinical Research Excellence and Safety (ACRES), a ... of a strategic alliance agreement, setting the stage ... is to enhance clinical research quality and safety ...
Breaking Biology Technology:Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 2Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 3Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 4IACRN and ACRES to Support Clinical Research Nurses 2IACRN and ACRES to Support Clinical Research Nurses 3
... InNexus,Biotechnology Inc., (OTC Bulletin Board: IXSBF; TSX ... commercializing the next,generation of monoclonal antibodies based on ... Morhet, CEO and Chairman, will,present at the 7th ... Mr. Morhet,s thirty-minute presentation to potential investors ...
... NOVATO, Calif., Oct. 28 , Financial Highlights ($ in millions, except per share data), Item ... Q3 2007 Comparison Total BioMarin Revenue $72.6 ... Product Revenue $33.3 ... $38.2 ...
... DiaGenic ASA (OSL:DIAG),today announced that it has ... leading panEuropean provider of gene expression-based,diagnostic testing ... following,CE marking scheduled in early2009, DiaGenic will ... in Europe its innovative blood-based,gene-expression diagnostic test ...
Cached Biology Technology:InNexus Biotechnology CEO to Present at the 7th Annual BIO Investor Forum 2BioMarin Announces Third Quarter 2008 Financial Results 2BioMarin Announces Third Quarter 2008 Financial Results 3BioMarin Announces Third Quarter 2008 Financial Results 4BioMarin Announces Third Quarter 2008 Financial Results 5BioMarin Announces Third Quarter 2008 Financial Results 6BioMarin Announces Third Quarter 2008 Financial Results 7BioMarin Announces Third Quarter 2008 Financial Results 8BioMarin Announces Third Quarter 2008 Financial Results 9BioMarin Announces Third Quarter 2008 Financial Results 10BioMarin Announces Third Quarter 2008 Financial Results 11BioMarin Announces Third Quarter 2008 Financial Results 12Diagenic Partners With DNAVision to Offer First Breast Cancer and Alzheimers Gene-Expression Blood Tests 2
(Date:9/30/2014)... Ecker, a Salk professor and Howard Hughes Medical ... have been named recipients in the 2014 round ... (NIH) through the BRAIN (Brain Research through Advancing ... The grant, announced September 30, provides more than ... over three years. , The BRAIN Initiative, launched ...
(Date:9/30/2014)... available in German . ... most expensive foods in the world. Because they grow underground, ... the distinctive smell of truffles is not only of interest ... the direction of the Goethe University Frankfurt have discovered that ... bacteria which are trapped inside truffle fruiting bodies. , White ...
(Date:9/30/2014)... pregnanteven with IVF? Here,s some hope: A new research ... The FASEB Journal , explains how scientists developed ... PAWP, which induced embryo development in human and mouse ... by the sperm cell during fertilization. , "We believe ... paradigm shift in our understanding of human fertilization by ...
Breaking Biology News(10 mins):Salk scientists receive $3 million for BRAIN Initiative grant 2On the trail of the truffle flavor 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2
... Sanford-Burnham Medical Research Institute, a nonprofit research institution ... the world, and Intrexon Corporation, a leading synthetic ... accelerate stem cell research. Under the agreement, Sanford-Burnham ... and gene regulation technologies that are not currently ...
... This press release is available in Spanish ... scientists are developing strategies to help livestock producers control ... in the United States. An economic ... (ARS) Agroecosystem Management Research Unit (AMRU) in Lincoln, Neb., ...
... drugs are taken off the market and a major reason ... reporting the development of a new way to predict those ... which could save patients from severe side effects and save ... of Chemical Information and Modeling . Yoshihiro Yamanishi and ...
Cached Biology News:Sanford-Burnham and Intrexon Corporation establish collaboration to accelerate stem cell research 2Sanford-Burnham and Intrexon Corporation establish collaboration to accelerate stem cell research 3Treating stable flies in pastures 2
Taq DNA polymerase, 10,000U...
... is the most thoroughly characterized enzyme available ... its overall utility and efficacy. , Its ... PCR applications. , It is QC ... AmpliTaq DNA Polymerase is a 94 kDa ...
Taq DNA Polymerase (T. aquaticus), 4 x 250 units. For PCR and other procedures requiring DNA polymerase activity at elevated temperatures. Category: Nucleotides & Enzymes & Biochemicals, Modifying En...
... GCpro Taq DNA Polymerase is a versatile ... for all PCR applications. GCpro Taq DNA ... expressed in E. coli, containing the DNA ... enzyme includes a highly processive 5'-3' DNA ...
Biology Products: