Navigation Links
Data mining algorithm explains complex temporal interactions among genes
Date:6/24/2010

Researchers at Virginia Tech, New York University (NYU), and the University of Milan, Italy, have created a data mining algorithm they call GOALIE that can automatically reveal how biological processes are coordinated in time.

Biological processes such as cell division, metabolism, and development must be carefully synchronized for proper cell function. How such events are coordinated in time is a complex problem in the field of systems biology. While researchers can gather temporal data about the activity of thousands of genes simultaneously, interpreting these datasets in order to understand higher order phenomena such as cell division requires the development of new analysis tools. The mathematically rigorous data mining algorithm GOALIE (Gene Ontology based Algorithmic Logic and Invariant Extractor) reconstructs temporal models of cellular processes from gene expression data. The researchers describe this algorithm in the early on-line Proceedings of the National Academy of Sciences (PNAS) to be released the week of June 21, 2010.*

The researchers developed and applied their algorithm to time-course gene expression datasets from the well-studied organism Saccharomyces cerevisiae, a budding yeast that is also used for raising bread dough and the manufacture of beer, wine, and distilled spirits. They applied their novel temporal logic-based algorithm to a range of yeast data sets involving cell division, metabolism, and various stresses. "A key goal of GOALIE is to be able to computationally integrate data from distinct stress experiments even when the experiments had been conducted independently," said Naren Ramakrishnan, professor of computer science at Virginia Tech, and lead author.

"GOALIE is part of a broader effort to combine data mining with modeling tools", said Bud Mishra, professor of computer science and mathematics with the Courant Institute of Mathematical Sciences at NYU, and corresponding author. Mishra
'/>"/>

Contact: Susan Trulove
strulove@vt.edu
540-231-5646
Virginia Tech
Source:Eurekalert

Page: 1 2 3 4

Related biology technology :

1. DNA Genotek's Oragene●ANIMAL DNA Collection Kit Plays Key Role in Determining the Genetic Cause of Chiari Malformation in Dogs
2. Transgenomic Awarded SBIR Grant to Support Development of SURVEYOR(R) Endonuclease Adaptor-ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation
3. Top Biopharma Company Adopts BioFortis Translational Research Software for Centralized Management and Mining of Clinical Biomarker Data
4. Transgenomic Introduces SURVEYOR(R) Endonuclease Adaptor-Ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation
5. U.S. PTO Reexamining Lumenis Patents
6. Landfill mining reduces environmental impact of growing waste
7. Landfill mining reduces environmental impact of growing waste
8. Landfill Mining
9. Detection of potentially deadly atrial fibrillation dramatically improved by new algorithm
10. DNA2.0 Awarded US Patents for Breakthrough Gene Optimization Technology -- Company's Unique Algorithm Enables Expression Yields up to 50 Times Greater than Competing Approaches
11. Bioheart, Inc., Announces Letter of Intent to Acquire MEDICALGORITHMICS, Ltd.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 2014 /PRNewswire-iReach/ -- A case study from Intel ... school,s bioengineering department and the Intel® Internet of ... Academic Program, UCSD,s research focuses on exploring the ... Photo - http://photos.prnewswire.com/prnh/20140819/137540 ... of Dr. Todd P. Coleman , Associate ...
(Date:8/20/2014)... 20, 2014 WriteResult®, a leading provider ... it has expanded its myPROpad™ ePRO tablet with the ... one of the most widely used and well-respected Patient ... status. The EQ-5D is used during clinical trials and ... that can be used to demonstrate Health-Related Quality of ...
(Date:8/19/2014)... 2014 One of the major ... an inadequate vascular supply. Nutrient and gas transport ... is critical for successful regeneration and integration into ... deficiencies in vascularization and promote angiogenesis in a ... scaffold design and architecture, and enhancing scaffolds with ...
(Date:8/19/2014)... Research and Markets  has announced the addition of ... Report" report to their offering. This report ... US$ Thousands by the following Product Segments: Media, Sera, and Reagents. ... Canada , Japan , ... Latin America . Annual estimates and forecasts are provided ...
Breaking Biology Technology:Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2EQ-5D™ Assessment Now Available for iPad 2Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2
... , , BRISBANE, Calif., Sept. 17 ... it will be collaborating with National Jewish Health(R)( )investigators in ... may play a role in idiopathic pulmonary fibrosis (IPF). InterMune ... from patients who participated in the Company,s Phase 3 clinical trials ...
... BETHESDA, Md., Sept. 16 American Capital Ltd. ... 15, it completed the sale of its portfolio company Axygen ... Inc., to Corning Incorporated for approximately $400 million. The ... fee income, from the equity invested by American Capital,s affiliated ...
... SAN MARINO, Calif., Sept. 16 Dr. M. Karen ... (Pink Sheets: VRAL), will address the 11th Annual SoCalBio Investor ... Custom Peptides on Chronic Inflammation," will take place mid-morning on ... The Loews Santa Monica Beach Hotel in Santa Monica, California. ...
Cached Biology Technology:InterMune Announces Collaboration With National Jewish Health on NIH-Supported Genetic Research in Idiopathic Pulmonary Fibrosis 2InterMune Announces Collaboration With National Jewish Health on NIH-Supported Genetic Research in Idiopathic Pulmonary Fibrosis 3American Capital Receives $182 Million In Proceeds From Sale of Axygen Bioscience 2American Capital Receives $182 Million In Proceeds From Sale of Axygen Bioscience 3American Capital Receives $182 Million In Proceeds From Sale of Axygen Bioscience 4Viral Genetics' Lead Scientist Dr. M. Karen Newell Will Present at 11th Annual SoCalBio Investor and Partnership Conference 2
(Date:8/21/2014)... pancreatitis involves the pancreas digesting itself resulting in severe ... the UK around 20,000 patients are diagnosed with the ... cure and treatment is restricted to intravenous fluid and ... Faculty of Life Sciences, who led the research, said ... from gall stones and excessive alcohol intake combined with ...
(Date:8/20/2014)... a study of 158 pregnant teenagers in Rochester, NY, ... intentional consumption of ice, cornstarch, vacuum dust, baby powder ... Cornell study. , Moreover, such teens had significantly lower ... eat nonfood substances. , Pregnant teens, regardless of pica, ... lead to iron deficiency and anemia. Low iron in ...
(Date:8/20/2014)... life can persist in a cold, dark world. A ... that examined waters and sediments from a shallow lake ... extreme environment supports microbial ecosystems. , The National ... has implications for life in other extreme environments, both ... are published in the current edition of the science ...
Breaking Biology News(10 mins):Insulin offers new hope for the treatment of acute pancreatitis 2Pica in pregnant teens linked to low iron 2University of Tennessee research uncovers subglacial life beneath Antarctic ice sheet 2
... Nature journal Leukemia suggests blocking part of ... leukemia resist treatment can increase the effectiveness of chemotherapy ... Medical Center report that their experimental combination treatment strategy ... was particularly effective at stopping a stubborn leukemia ...
... August 8, 2013 Research and ... addition of the "Fingerprint Biometrics - Global ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,This report ... in US$ Thousands by the following Product ...
... world full of hungry predators, prey animals must be constantly ... challenge when it comes to defending themselves. "One of ... they can,t run away," says John Orrock, a zoology professor ... necessarily hide, so what can you do? Some plants make ...
Cached Biology News:Study suggests way to fight therapy resistant leukemia by blocking DNA repair 2Study suggests way to fight therapy resistant leukemia by blocking DNA repair 3Fingerprint Biometrics: Automated FIS, and Non-AFIS - Global Strategic Business Report - 2013 2Eavesdropping plants prepare to be attacked 2
... high-performance pump, available in a single and twin ... valve design. With the most compact, lightweight package ... use in portable air and gas applications., ... and T2-01TH). , Delivers 1.5 and 2.0 liters ...
... single use spatulas have been designed to ... are for those interested in eliminating the ... Each spatula is individually packaged, RNase/DNase free, ... is a new product number, created to ...
... RNA Spike-In Kit contains in vitro synthesized, ... complementary control probes on Agilents microarrays, with ... as a positive microarray control in the ... kit is a required component of the ...
... Protein Purification System provides a simple, ... purification of glutathione-S-transferase (GST) fusion proteins. ... are used to isolate GST-tagged protein ... lysate using either a manual (requires ...
Biology Products: