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Data for Oncothyreon's PX-12 and PX-866 presented at AACR Annual Meeting
Date:4/16/2008

BELLEVUE, WA, April 16 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY) (TSX:ONY) announced today that data from pharmacokinetic studies of PX-12 and preclinical studies of PX-866 were presented at the Annual Meeting of the American Association for Cancer Research (AACR) in San Diego, held April 12-16, 2008. Information from the studies may guide future clinical development plans for these product candidates. Oncothyreon is currently conducting a Phase 2 trial of PX-12 in patients with advanced pancreatic cancer and PX-866 is expected to enter a Phase 1 trial in patients with advanced cancers in the second quarter of 2008.

PX-12

PX-12 is an irreversible inhibitor of thioredoxin (Trx)-1, a protein that is over-expressed in many tumor types and is associated with aggressive tumor growth and poor prognoses. In a previous Phase 1 study, PX-12 treatment lowered circulating levels of Trx-1 in patients and a Trx-1 decrease of 25% or greater was associated with increased survival.

The current study examined Trx-1 levels in the serum of patients receiving PX-12 in two ongoing clinical trials and in healthy volunteers, and the data were reported in a poster session yesterday (Abstract # 4453). Key findings of the study are:

- PX-12 reduced plasma Trx-1 levels in all patients with initial levels

greater than 18 ng/mL, the upper limit of the normal range. Patients

with normal Trx-1 levels remained in the normal range following PX-12

treatment.

- Thirty-three percent of patients with elevated Trx-1 levels achieved

stable disease with PX-12 treatment. No patients achieved stable

disease if their starting Trx-1 levels were within the normal range.


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SOURCE Oncothyreon Inc.
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