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Data Published in Nature Cell Biology Reveal Novel Function of Drug Target EpCAM in Cancer Cell Signalling
Date:1/13/2009

tibody, is being tested in a phase 1 clinical trial for the treatment of patients with gastrointestinal or lung cancer. In addition, Micromet is conducting a phase 1 clinical trial with adecatumumab, a human monoclonal antibody binding to EpCAM, investigating its use in combination with docetaxel for patients with metastatic breast cancer. A phase 2 study of adecatumumab in colorectal cancer patients with liver metastases is planned to be initiated this year.

(1) Dorothea Maetzel, Sabine Denzel, Brigitte Mack, Martin Canis, Philip Went, Michael Benk, Cuong Kieu, Peer Papior, Patrick A. Baeuerle, Markus Munz & Olivier Gires. Nuclear signalling by tumor-associated antigen EpCAM. Nature Cell Biology. Published online: 11 January 2009; | doi:10.1038/ncb1824

About Micromet, Inc.

Micromet, Inc. (www.micromet-inc.com) is a biopharmaceutical company with offices in Bethesda, Maryland and Munich, Germany. The Company is developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases. The Company uses its proprietary BiTE(R) antibody platform to create a new class of antibodies that specifically activate T cells from the patient's own immune system to eliminate cancer cells or other disease-related cells. Four of the Company's antibodies are currently in clinical trials, with the remainder of its product pipeline in preclinical development. The Company's lead program is a BiTE antibody known as blinatumomab, or MT103. It is in a phase 2 clinical trial for the treatment of patients with acute lymphoblastic leukemia and a phase 1 clinical trial for the treatment of patients with non-Hodgkin's lymphoma. Micromet is developing blinatumomab in collaboration with MedImmune, a subsidiary of AstraZeneca plc. Micromet's second BiTE antibody in clinical development is MT110, which targets the epithelial cell a
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