Navigation Links
Data Published in Nature Cell Biology Reveal Novel Function of Drug Target EpCAM in Cancer Cell Signalling
Date:1/13/2009

Findings Support Development of Micromet's EpCAM-specific Antibody Therapeutics

BETHESDA, Md., Jan. 13 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases today announced the publication of an article in the peer-reviewed journal Nature Cell Biology(1) revealing a novel signalling function of the epithelial cell adhesion molecule, or EpCAM (CD326), which is expressed with high frequency on many types of solid tumors. Micromet is developing two antibody drug candidates that target EpCAM: MT110, a T-cell engaging BiTE(R) antibody, and adecatumumab (MT201), a human monoclonal antibody.

Principal investigator and senior author of the article was Micromet's scientific collaborator Olivier Gires at the Grosshadern Hospital of Munich University, Germany. The new data by Gires and colleagues show that only cancer cells have an actively signalling form of EpCAM, while normal cells have an inactive form of EpCAM. When normal cells received the activated form of EpCAM, as is found in tumor cells, and were then injected into mice, they behaved like cancer cells in that they formed tumors.

"The findings of our latest publication may explain why certain cancer patients with a high level of EpCAM expression on their tumor cells have a reduced overall survival compared to patients with low levels of EpCAM on their tumor cells. Since activated EpCAM is expressed on the surface of cancer cells and their stem cells, it is a very promising target for our antibody-based drug candidates," commented Micromet's Senior Vice President and Chief Scientific Officer, Patrick Baeuerle.

Micromet is developing two antibodies binding to EpCAM. MT110, an EpCAM-specific BiTE an
'/>"/>

SOURCE Micromet, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice
2. Technique for Creating Authentic Rat Embryonic Stem Cells Published in Cell
3. Wound Management Technologies, Inc. Announces a Published Case Study
4. Clinical Study of Intermezzo(R) for the Treatment of Middle of the Night Awakening Published in SLEEP
5. More Evidence Published That Epidemics of Childhood Obesity, Type 2 Diabetes and Metabolic Syndrome are Linked to Immunization
6. PTC124 Shows Promising Activity in Cystic Fibrosis; Phase 2 Proof-of-Concept Data Published in the Lancet
7. Results of Study in Pre-School Children Published in Clinical Pediatrics Adds to Support for Importance of Dietary DHA Intake
8. The Protein Tomography(TM) Award Now Published on Sidecs Homepage
9. Regado Biosciences REG1 Anticoagulation System Study Results Published in the Journal of Thrombosis and Haemostasis
10. Peregrine Pharmaceuticals Reports Studies Published in Science Highlight Key Role of Phosphatidylserine (PS) in Viral Infections
11. AEterna Zentaris: Article on Phase 2 Trial with Cetrorelix in BPH to be Published in European Urology Journal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... September 30, 2014 Rainbow Scientific, ... research products, recently opened an online store to ... culture product lines developed and manufactured by Biological ... store include Biological Industries’ Nutristem® serum-free, xeno-free reagents ... embryonic stem cell (hESC) culture. , The ...
(Date:9/30/2014)... Whitehouse Laboratories is pleased to ... Parenteral Drug Association (PDA) to host a unique ... closure integrity testing. This lecture/laboratory course will examine the ... detailed in the recently proposed revision to USP 1207 ... will span container closure integrity testing (leak testing) critical ...
(Date:9/29/2014)... 30, 2014 Each year in ... require medical attention. In the military, burn injury ... to battlefield medical care. More than 800 service ... Burn wounds heal slowly, remain inflamed and often ... physically debilitating and functionally damaging. While developments in ...
(Date:9/29/2014)... BEACH, Va. , Sept. 29, 2014 /PRNewswire-USNewswire/ ... from the fields of cartilage repair, regeneration, allograft ... attendees from around the world gathered to discuss ... LifeNet Health Institute of Regenerative Medicine symposium, ... Direction . Topics included Orthopedic Biosurgery, Minced Juvenile ...
Breaking Biology Technology:Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4Faster Healing with Fewer Scars 2World Renowned Experts Discuss Future Of Cartilage Regeneration 2World Renowned Experts Discuss Future Of Cartilage Regeneration 3
... Organization Exceeds Expectations, MEMPHIS, Tenn., Nov. ... exclusively focused on oncology, announced today that ... as the company continues,to experience banner growth. ... to consistently exceed client expectations, and we ...
... N.J., Nov. 10 Aton Pharma, Inc., ... a recent,survey of ophthalmologists regarding issues in ... dry eye. Aton provides the dry eye ... sustained release prescription insert that helps to ...
... 3SBio Inc. (Nasdaq:,SSRX), a leading biotechnology company focused ... in China,today announced that it has filed with ... approval of NuLeusin for the treatment of late,stage ... expected to,be the only treatment of this kind ...
Cached Biology Technology:ACORN CRO Continues Growth in Strong Third Quarter 2Dry Eye Survey: Ophthalmologists Cite Treatment Limitations/Gaps in Treatment of Moderate to Severe Dry Eye 2Dry Eye Survey: Ophthalmologists Cite Treatment Limitations/Gaps in Treatment of Moderate to Severe Dry Eye 3Dry Eye Survey: Ophthalmologists Cite Treatment Limitations/Gaps in Treatment of Moderate to Severe Dry Eye 4Dry Eye Survey: Ophthalmologists Cite Treatment Limitations/Gaps in Treatment of Moderate to Severe Dry Eye 53SBio Inc. Files for SFDA Approval of NuLeusin 23SBio Inc. Files for SFDA Approval of NuLeusin 33SBio Inc. Files for SFDA Approval of NuLeusin 4
(Date:9/29/2014)... research team says recently identified radiation detection properties of ... doors for homeland security and medical advances. , In ... issue of Optics Letters , UT Arlington Physics ... method to fabricate transparent nanoscintillators by heating nanoparticles composed ... is formed. A scintillator refers to a material ...
(Date:9/29/2014)... has presented Dr. Cristin Samper, president and CEO ... Order of San Carlos. , The Order of ... military officers who have made outstanding contributions to ... relations. , An international authority on conservation biology ... the Colombian Residence in New York to receive ...
(Date:9/29/2014)... annual Advocacy Awards will ... advancing medical progress to improve the health and ... take place on Wednesday, March 11, 2015, at ... , The 2015 Advocacy Award winners are ABC,s ... founder of the Milken Institute and FasterCures; Dr. ...
Breaking Biology News(10 mins):UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3Research!America to honor leaders in medical and health research advocacy 2Research!America to honor leaders in medical and health research advocacy 3Research!America to honor leaders in medical and health research advocacy 4
... warming despite emitting small amounts of an important greenhouse gas, ... of Edinburgh suggests that plant leaves account for less than ... is considered to be about 25 times more effective than ... a previous scientific study which had suggested that plants were ...
... WASHINGTON, April 29, 2010 The American Chemical ... has awarded its 2010 research grant to Scottish ... strides in expanding green chemistry and engineering practices ... the one-year $150,000-grant to further his study of ...
... Thomas Miller , an internationally recognized expert at ... and genetics, has been chosen by the U.S. Department ... Fellowship . Miller is one of only ten ... applicants undergo a rigorous selection process, are highly accomplished ...
Cached Biology News:ACS Green Chemistry Institute Pharmaceutical Roundtable award goes to Scottish chemist 2US Department of State names UCR entomologist a Jefferson Science Fellow 2US Department of State names UCR entomologist a Jefferson Science Fellow 3