Navigation Links
Data Published in Cell Stem Cell Demonstrates Potent Anti-Cancer Activity for OncoMed Pharmaceuticals' Lead Antibody
Date:8/6/2009

REDWOOD CITY, Calif.,, Aug. 6 /PRNewswire/ -- OncoMed Pharmaceuticals, Inc., a clinical-stage company developing novel antibody therapeutics that target cancer stem cells, today announced the publication in Cell Stem Cell of data demonstrating potent anti-cancer activity in colon and breast cancer models for the company's first product candidate, OMP-21M18, underlining the therapeutic potential of targeting cancer stem cells to treat solid tumors. OMP-21M18 is currently in Phase 1 clinical testing.

"OMP-21M18 specifically targets cancer stem cells, a type of tumor cell responsible for driving tumor initiation, growth and recurrence. Research published in Cell Stem Cell suggests that reducing the ratio of these cells within tumors may dramatically improve anti-cancer treatment," said Timothy Hoey, Ph.D., Vice President, Cancer Biology of OncoMed Pharmaceuticals and a co-author of the paper. "In models of colon and breast cancer, we observed that treatment with OMP-21M18 significantly decreased the proportion of cancer stem cells found in tumors compared to chemotherapy alone. In addition, we demonstrated that blocking a key cancer stem cell pathway impacts tumor cell proliferation, growth and recurrence."

OMP-21M18 is a monoclonal antibody that blocks DLL4 signaling to reduce tumor growth two ways: by reducing cancer stem cell frequency and by disrupting angiogenesis. In a series of published experiments using primary human tumors in xenograft models, OncoMed scientists assessed the effect of OMP-21M18 alone and in combination with approved chemotherapeutic agents versus chemotherapy alone on the frequency of cancer stem cells in treated tumors. Results demonstrate that treatment with OMP-21M18 as a single agent or in combination with standard chemotherapeutic agents significantly decreases the ratio of cancer stem cells found in colon and breast tumors. Notably, treatment with chemotherapy alone was demonstrated to increase the ratio of tumorigenic stem cells found in colon and breast tumors. Further, OMP-21M18 was shown to significantly delay tumor recurrence by inhibiting cancer stem cells in colon and breast tumor models. Taken together, these data indicate that treatment with certain chemotherapeutic agents alone may actually serve to amplify the risk for recurrence or more aggressive tumor activity by increasing the ratio of cancer stem cells within tumors.

In addition to inhibiting cancer stem cell frequency, thereby delaying the re-growth or recurrence of tumors, anti-DLL4 therapy was shown to reduce tumor growth and tumor cell proliferation and disrupt tumor angiogenesis. Moreover, OMP-21M18 displayed additive activity in reducing tumor volume when combined with traditional chemotherapy.

"This research represents an entirely new way of looking at the treatment of solid tumor cancers, recognizing that tumors are made up of different types of cells and targeting cancer stem cells has a profound effect on tumor growth and recurrence," said Paul Hastings, President and Chief Executive Officer of OncoMed Pharmaceuticals. "OMP-21M18 is the first of several promising monoclonal antibodies in development at OncoMed. We have seen potent anti-cancer stem cell activity, and we look forward to reporting results from our initial trials as this product advances through the clinic."

These data are published in the August 7, 2009 edition of Cell Stem Cell in an article titled "DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor Initiating Cell Frequency." The authors of the article include Dr. Michael Clarke of Stanford University, Dr. Hoey and Dr. Austin Gurney of OncoMed Pharmaceuticals, where OMP-21M18 was discovered and is being developed. OMP-21M18 was evaluated using OncoMed's proprietary tumor models, using xenografts established from primary human tumors. These models are designed to be more directly representative of human tumors than the cell lines used in standard cancer research.

About OMP-21M18

OMP-21M18 is a monoclonal antibody optimized to block a key signaling pathway in cancer stem cells. Specifically, OMP-21M18 selectively targets Delta-like ligand 4 (DLL4), an activator of Notch signaling, which is a pathway known to be important in stem cells and cancer. Blocking DLL4 results in broad-spectrum anti-tumor activity via multiple mechanisms, including disrupting angiogenesis, inhibiting cancer stem cell growth and promoting cell differentiation. OMP-21M18 is currently in a Phase 1 clinical trial in patients with advanced solid tumors. This trial will also assess pharmacokinetics and provide initial indications of efficacy. OMP-21M18 is part of OncoMed's Notch pathway collaboration with GlaxoSmithKline.

About OncoMed Pharmaceuticals

OncoMed Pharmaceuticals is a clinical-stage company that discovers and develops novel therapeutics targeting cancer stem cells, the cells believed to be capable of driving tumor growth, recurrence and metastases. A leader in cancer stem cell research, the company has established a library of antibodies to cancer stem cell proteins for the treatment of solid tumors such as pancreatic, breast, colorectal and lung cancers. OncoMed's lead candidate, OMP-21M18 is currently in Phase I clinical trials. In addition to OMP-21M18, OncoMed's pipeline includes several novel preclinical product candidates targeting multiple validated cancer stem cell pathways. Privately-held, OncoMed's investors include: Nomura Phase4 Ventures, US Venture Partners, Latterell Venture Partners, Morgenthaler Ventures, The Vertical Group, Adams Street Partners, De Novo Ventures, Delphi Ventures, Bay Partners and GlaxoSmithKline. Additional information can be found at the company's website: www.oncomed.com.


'/>"/>
SOURCE OncoMed Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related biology technology :

1. Study Published in Clinical Cancer Research Confirms Potential Of Peregrines Bavituximab Combined With Radiation In Lung Cancer
2. PharmAthene Named as Contractor in $13.9 Million Award Notice Published by the Department of Health and Human Services
3. In response to a New England Journal of Medicine article published yesterday and subsequent media coverage, Eli Lilly and Company issued the following statement:
4. Vasogens Research Published in European Journal of Neuroscience
5. The LANCET Published ENDORSE, the Largest Multinational Study Showing That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE Prophylaxis
6. Newly Published EPA RCRA Method 6800 Supports AIT Technology
7. Pyratine-6(TM) Study Published in Journal of Drugs in Dermatology
8. WHI Findings Published in JAMA Do Not Affect Clinical Guidance for the Appropriate Use of Hormone Therapy
9. Synvista Therapeutics Highlights Newly Published Data Demonstrating the Value of Haptoglobin Genotype Testing In People with Diabetes
10. Complete ANX-530 Safety Data to be Published in the 2008 Proceedings of the American Society of Clinical Oncology
11. Accurate Identification of Tumor Origin Using MicroRNAs is Published by Rosetta Genomics Scientists and Collaborators in Nature Biotechnology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... (PRWEB) , ... April 27, 2016 , ... ... of Lewis Roca Rothgerber Christie LLP as an associate in the firm’s Intellectual ... and international electrical, mechanical and electromechanical patent applications. He has an electrical engineering ...
(Date:4/26/2016)... ... April 26, 2016 , ... The European Patent Office (EPO) ... of three finalists for the European Inventor Award 2016 in the category "Non-European countries." ... announced at a ceremony in Lisbon on June 9th. , The human capacity to ...
(Date:4/26/2016)... ... 2016 , ... Mr. Palmer created the RPO business for Ceridian and lead ... managed services contract in the U.S. intelligence community with The SI (a Lockheed Martin ... Younger, founder of Accolo. “We are growing and his experience guiding our expansion ...
(Date:4/26/2016)... ... ... BioFactura, Inc ., a biopharmaceutical research and manufacturing company, announced today the ... significant oversubscription of the original $1.5M target. The funds will be used to ... , Chief Executive Officer and President, Darryl Sampey founded BioFactura in 2004 ...
Breaking Biology Technology:
(Date:3/23/2016)... , March 23, 2016 ... erhöhter Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender ... das Unternehmen mit SpeechPro zusammenarbeitet, um erstmals ... Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im Rahmen ...
(Date:3/22/2016)... and SANDY, Utah , March ... operates the highest sample volume laboratory in ... and UNIConnect, leaders in clinical sequencing informatics and molecular ... of a project to establish the informatics infrastructure for ... NSO has been contracted by the Ontario Ministry ...
(Date:3/18/2016)... -- --> --> Competitive ... Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance & Detection Systems ... security market and the continuing migration crisis in the ... has led visiongain to publish this unique report, which ... defence & security companies in the border security market ...
Breaking Biology News(10 mins):