Navigation Links
Data Presented on Monogram HIV Tropism Tests at Retrovirus Conference sets New Standards of Assay Sensitivity
Date:2/7/2008

erienced treatment failure on a CCR5 antagonist.

Trofile has been proven to be a critically important tool for ensuring that CCR5 antagonists are administered safely -- and the only such tool currently available. This has been reinforced by the issuance by the Department of Health and Human Services of its updated guidelines for HIV treatment, in which it recommended that a tropism test should be used prior to initiation of CCR5 treatment and may also be considered at failure of therapy. The DHHS guidelines also cited the Trofile assay by Monogram as the assay "used to screen patients who were participating in studies that formed the basis of approval for Selzentry, the only CCR5 inhibitor currently available.

Data from the other presentations show specific markers of HIV resistance to CCR5 antagonists, particularly the role that mutations in the V3 loop play. Based on these and other studies, Monogram has been the first to identify specific changes that have become a standard marker of CCR5 antagonist resistance.

"Monogram tests, particularly our Trofile Assay, have been pivotal to CCR5 drug development programs," said Monogram CEO William Young. "Trofile is well established as the only clinically validated tropism assay and as the data presented this week reaffirms, our enhanced tropism assay, which we expect to be commercially available soon, sets an even higher standard of sensitivity for CCR5 positive patients."

Monogram's tests have been used throughout the development of the CCR5 class of drugs. In addition to the use of Trofile for patient selection and the use of Phenosense for optimization of background therapy in the phase II and phase III clinical trials of Pfizer's maraviroc (Selzentry(TM)) and Schering Plough's vicriviroc, Monogram has also recently signed an agreement with Incyte Corporation to provide resistance and tropism testing for Incyte's investigational CCR5 antagonist, INCB9471. INCB9471 is currently in Phase II de
'/>"/>

SOURCE Monogram Biosciences, Inc
Copyright©2008 PR Newswire.
All rights reserved

2

GOOD

Page: 1 2 3 4 5 6

Related biology technology :

1. Three Studies by Independent Scientists Highlighting Pressure Cycling Technology (PCT) to be Presented this Week at the British Mass Spectrometry Societys 29th Annual Meeting
2. Survival Data Presented From Phase II Study of Investigational Drug ZD4054 in Hormone-Resistant Prostate Cancer Patients
3. New Data Presented on Immunocytokine Fusion Protein Further Supports Broad Anti-Cancer Potential Of Peregrines Anti-PS Technology Platform
4. Results of Colon Cancer Study Utilizing Pressure Cycling Technology (PCT) Presented at the American College of Gastroenterology Annual Scientific Meeting
5. Kuvan, Naglazyme and Aldurazyme Data to Be Presented at the 57th Annual Meeting of the American Society of Human Genetics
6. Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings
7. Three PDX (Pralatrexate) Studies Presented at the 2007 AACR-NCI-EORTC Conference
8. Salugens Award-Winning Research on Using DNA Information to Customize Nutritional Supplementation for Weight Loss Presented at the Second Annual Bruce Ames International Symposium on Nutritional Genomics at the University of California, Davis
9. Reverse Cholesterol Transport by RVX-208 a Small Molecule for ApoA-I Production Increase Presented at American Heart Association Scientific Meeting
10. Genasense(R) Triple Combination Therapy in Advanced Melanoma Presented at Chemotherapy Foundation Symposium
11. Promising Data ATIR Studies Presented by NIH Investigators
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/7/2008)...ected to aid drug discovery by allowing for the ra...gle reaction, ST. LOUIS, Oct. 7 /PRNewswire-First...o announce that it has signed an exclusive licensi...bana-Champaign allowing,Sigma-Aldrich to offer res...ogates for use in Suzuki-Miyaura coupling to resea...
(Date:10/7/2008)...s to focus on new patient data supporting the Ross...ynerGraft processed human heart .../- CryoLife, Inc. (NYSE: C...ocessing company, announced today,that cardiovascu...e in the,Ross Summit 2008, a two-day surgical cong...
(Date:10/7/2008)...Institutes of Health, The Infectious Disease Resea...Launch and Board of Advisors, SEATTLE, Oct. 7 /PR...,Initiative today announced its first acquisition ...osis (TB) drug candidates. Agreements were reached...nd the Microbial Chemistry,Research Foundation (MC...
(Date:10/7/2008)... Oct. 7 /- BioEnergy International, L...r and manufacturer of,next-generation, renewable b...f Norman R. Augustine to its Board of Advisors eff...f distinguished leadership and innovation,at the h...g in his role as,Chairman and Chief Executive Offi...
Breaking Biology Technology:Sigma-Aldrich and the University of Illinois Offer New Boronic Acid Surrogates to Researchers Worldwide Through Licensing Agreement 2Sigma-Aldrich and the University of Illinois Offer New Boronic Acid Surrogates to Researchers Worldwide Through Licensing Agreement 3CryoLife Hosts Worldwide Surgical Congress for the Ross Procedure 2CryoLife Hosts Worldwide Surgical Congress for the Ross Procedure 3CryoLife Hosts Worldwide Surgical Congress for the Ross Procedure 4Update: The Lilly TB Drug Discovery Initiative Begins Work on New Compounds to Fill Early-Stage TB Drug Pipeline 2Update: The Lilly TB Drug Discovery Initiative Begins Work on New Compounds to Fill Early-Stage TB Drug Pipeline 3Update: The Lilly TB Drug Discovery Initiative Begins Work on New Compounds to Fill Early-Stage TB Drug Pipeline 4Update: The Lilly TB Drug Discovery Initiative Begins Work on New Compounds to Fill Early-Stage TB Drug Pipeline 5BioEnergy International, LLC Announces Norman R. Augustine to Join Advisory Board 2BioEnergy International, LLC Announces Norman R. Augustine to Join Advisory Board 3
...icane Increases Attention of Weather Forecasting ...bel to hit the East Coast, the accuracy of weather...their homes and businesses. People are watching TV... find out the latest path of the storm. A new prod...provider of weather forecasting technology and Int...
...d you like some fries with your Internet connectio...tly began installing wireless fidelity (Wi-Fi) Int...art of a six-month pilot program. These Milwaukee ...e San Francisco Bay Area, Metropolitan New York Ci...ew McDonald,s Wireless Internet service. , ,Custom...
... confused. Governor Doyles new Growth Council seem...that theyre out of touch. After looking at the ros... three women were mentioned, to say nothing of min...t-finding mission and found that: , ,1) Four out o...omen, Gen Xers (b. 1961-1981), and minorities (Sou...
...ON, WI - Even as the State Assembly Ways and Means...-- a measure that would end state and local sales ... Representatives was passing a measure that, if it.... , ,The U.S. House Tuesday passed H.R. 49 , whic...on taxation of Internet connectivity. The bill wou...
Other Biology Technology:Hurricane Ups Weather Forecasting Attention For Madison Firm 2Wisconsin McDonalds Go Wireless 2State and Feds Race to Stop Taxation of Internet Access 2State and Feds Race to Stop Taxation of Internet Access 3State and Feds Race to Stop Taxation of Internet Access 4
(Date:10/7/2008)...imensional. That,s true even in the laboratory, wh...y develop and what happens when their growth is ab...g to develop three-dimensional cell culture system... drugs in a system that more closely mimics the wa...nt is the cost of commercial media for growing suc...
(Date:10/7/2008)...f Health (NIH) today announced the first awards fo...oundation for efforts to explore how complex commu... influence health and disease. The funding, estima...support the development of innovative technologies...lysis and an examination of some of the ethical, l...
(Date:10/7/2008)...ong Li Lab has characterized a mechanism that allo...n oocytes. By tracking chromosome movement in live...es can recruit to their vicinity a protein called ... the majority of the cytoplasm a requirement for ...he other daughter cell (called a polar body) resul...
(Date:10/7/2008)... Allergy and Infectious Diseases (NIAID), part of ...new grants to develop new and better diagnostics a...ar attack. Several of these grants were awarded un...enables NIAID within the Department of Health and ...to help stimulate research on medical countermeasu...
Breaking Biology News(10 mins):Egg whites solve the 3-D problem 2Human Microbiome Project awards funds for technology development, data analysis and ethical research 2Human Microbiome Project awards funds for technology development, data analysis and ethical research 3Human Microbiome Project awards funds for technology development, data analysis and ethical research 4NIAID announces 25 new awards to develop radiation countermeasures 2NIAID announces 25 new awards to develop radiation countermeasures 3Blue Cross and Blue Shield of Oklahoma Launches an Integrated Medical Dental Health Program 16385 1Blue Cross and Blue Shield of Oklahoma Launches an Integrated Medical Dental Health Program 16385 2Blue Cross and Blue Shield of Oklahoma Launches an Integrated Medical Dental Health Program 16385 3Indivumed Appoints Annette Kassen as Vice President Clinical Research 4500 1Indivumed Appoints Annette Kassen as Vice President Clinical Research 4500 2Module map links embryonic stem cells and cancer stem cells 16381 1Module map links embryonic stem cells and cancer stem cells 16381 2Researchers close in on origins of main ingredient of Alzheimers plaques 2831 1Researchers close in on origins of main ingredient of Alzheimers plaques 2831 2Researchers close in on origins of main ingredient of Alzheimers plaques 2831 3
...ia School of Medicine describe the basis for devel...ient,s nervous system to a thought-driven artifici... together years of spinal-cord injury research - i... , "We,re at a junction now of developing a new a...r author Douglas H. Smith, MD, Professor of Neuros...
...he National Museum of Natural History in Washingto...olve the mysterious identity of what they regard a... Their chemical analysis indicates that the organi...issue of the journal of Geology, published by the ... (pronounced pro-toe-tax-eye-tees), the organism w...
...translationally controlled tumor protein) are redu...than normal, indicating that the protein plays a m..., said researchers at Baylor College of Medicine i... , Work in his laboratory shows that TCTP plays a...n brain), a protein controlling growth and differe...
..., a bee. It all depends on what their job is. , R...uccess in adapting to cooler climates is their abi...hen flying to flowers. Whether and how they maint... now scientists from the University of Washington ... bumblebee colonies and have discovered some answe...
Other Biology News:Conceptualizing a cyborg 2Prehistoric mystery organism verified as giant fungus 2Prehistoric mystery organism verified as giant fungus 3Prehistoric mystery organism verified as giant fungus 4Bumblebee house warming -- it takes a village 2Bumblebee house warming -- it takes a village 3